Mesenchymal Cell News Volume 12.11 | Mar 24 2020

TOP STORY

Long Non-Coding RNA GRASLND Enhances Chondrogenesis via Suppression of Interferon Type II Signaling Pathway

Investigators showed that the silencing of GRASLND resulted in lower accumulation of cartilage-like extracellular matrix in a pellet assay, while GRASLND overexpression – either via transgene ectopic expression or by endogenous activation via CRISPR-dCas9-VP64 – significantly enhanced cartilage matrix production. [eLIFE] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Long Non-Coding RNA-H19 Stimulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via the microRNA-149/SDF-1 Axis

Overexpressed H19 and stromal cell-derived factor-1 (SDF-1) and poorly expressed miR-149 were found in rats with osteogenic differentiation. H19 increased SDF-1 expression by binding to miR-149. [J Cell Mol Med] Full Article

Effect of the Deuterium on Efficiency and Type of Adipogenic Differentiation of Human Adipose-Derived Stem Cells In Vitro

Researchers found that high deuterium content significantly inhibited in vitro adipogenic differentiation of human adipose-derived stem cells compared to the groups with natural and low deuterium content. [Sci Rep] Full Article

Extracellular Vesicles Derived from Human Adipose-Derived Stem Cells Promote the Exogenous Angiogenesis of Fat Grafts via the let-7/AGO1/VEGF Signaling Pathway

Human adipose-derived stem cell-extracellular vesicles could improve the survival of fat grafts by promoting exogenous angiogenesis and enhanced the proliferation, migration, tube formation and vascular endothelial growth factor (VEGF) secretion of vascular endothelial cells. [Sci Rep] Full Article

Increased Exhaustion of the Subchondral Bone-Derived Mesenchymal Stem/ Stromal Cells in Primary versus Dysplastic Osteoarthritis

Investigators showed that pathology of primary osteoarthritis was accompanied by bone MSC exhaustion, while biomechanical dysfunction associated with hip dysplasia could induce secondary osteoarthritis without this MSC impairment. [Stem Cell Rev Rep] Abstract

IN VIVO

miR-155-5p Inhibition Rejuvenates Aged Mesenchymal Stem Cells and Enhances Cardioprotection following Infarction

Scientists investigated the significance of miR-155-5p in regulating MSC senescence and whether inhibition of miR-155-5p could rejuvenate aged MSCs to enhance their therapeutic efficacy for myocardial infarction. [Aging Cell] Full Article

Biomimetic Mineralizable Collagen Hydrogels for Dynamic Bone Matrix Formation to Promote Osteogenesis

The authors demonstrated that the biomimetic mineralized hydrogel could up-regulate osteogenic genes and protein expression of bone marrow MSCs, thus enhancing osteogenesis in vivo. [J Mater Chem B] Abstract | Graphical Abstract

Hypoxia-Preconditioned Mesenchymal Stem Cells Prevent Renal Fibrosis and Inflammation in Ischemia-Reperfusion Rats

MSCs derived from rats and humans were incubated in 1% O₂ conditions (1%O₂ MSCs) for 24 hours. After ischemia-reperfusion injury, 1%O₂ MSCs or MSCs cultured under normoxic conditions (21%O₂ MSCs) were injected through the abdominal aorta. Administration of rat 1%O₂ MSCs attenuated renal fibrosis and inflammation more significantly than rat 21%O₂ MSCs. [Stem Cell Res Ther] Full Article

Administration of Allogeneic Mesenchymal Stem Cells in Lengthening Phase Accelerates Early Bone Consolidation in Rat Distraction Osteogenesis Model

Single injection of MSCs during lengthening phase significantly increased bone volume fraction, mechanical maximum loading, and bone mineralization of the regenerate. [Stem Cell Res Ther] Full Article

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A Systematic Review of Mesenchymal Stem Cell Exosomes for Cartilage Repair and Regeneration

The authors assessed the preclinical studies that used MSC exosomes for cartilage repair. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

AgeX Therapeutics Licensee ImStem Biotechnology Announces FDA Has Lifted the Hold and Cleared the Investigational New Drug Application for IMS001 for the Treatment of Multiple Sclerosis

AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has received notification from the FDA that it has lifted the hold and cleared the Investigational New Drug application to evaluate IMS001 for the treatment of multiple sclerosis. IMS001 is a formulation of cells derived from AgeX pluripotent stem cells induced to differentiate into MSCs and through a proprietary method using a trophoblast intermediate stage for the treatment of neurological, autoimmune, and rare orphan diseases. [AgeX Therapeutics, Inc.] Press Release

Researchers Are Tracking Another Epidemic, Too—of Misinformation

When five researchers at the University of Washington, Seattle, launched the new Center for an Informed Public back in December 2019, they had no idea what was coming. The center aims to study how misinformation propagates and use the findings to “promote an informed society, and strengthen democratic discourse. Now, just a few months later, the coronavirus pandemic is generating a tidal wave of information—some of it accurate, some not so much—that has saturated social and traditional media.” [ScienceInsider] Editorial

After Conference Cancellations, Some Scientists Find a Way

As scores of academic meetings get upended due to COVID-19, researchers are turning to virtual replacements. [The Scientist] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

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NEW Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine)

Research Specialist – Stem Cells for Regenerative Medicine (University of Illinois at Chicago)

Postdoctoral Fellow – Osteoarthritis, Mechanobiology, and Regenerative Medicine (Oklahoma Medical Research Foundation)

Postdoctoral Associate – IDH Pathways in Sarcomas (University of Miami)

Postdoctoral Scholar – Cancer Research in Sarcoma (The Ohio State University)

Postdoctoral Position – Stem Cell Pluripotency, Reprogramming and Cancer Biology (Cancer Research Center of Lyon)

Senior Research Scientist or Postdoctoral Fellow – Sarcoma Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

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