Mesenchymal Cell News Volume 12.14 | Apr 14 2020

TOP STORY

Regeneration of Pulpo-Dentinal-Like Complex by a Group of Unique Multipotent CD24a⁺ Stem Cells

Multipotent dental pulp regenerative stem cell exhibited enhanced osteogenic/odontogenic differentiation capabilities and could form regenerative dentin and neurovascular-like structures that mimicked native teeth in vivo. [Sci Adv] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Soft Extracellular Matrix Enhances Inflammatory Activation of Mesenchymal Stromal Cells to Induce Monocyte Production and Trafficking

By engineering hydrogels with tunable biophysical parameters relevant to bone marrow where MSCs naturally reside, scientists showed that soft extracellular matrix maximized the ability of MSCs to produce paracrine factors that have been implicated in monocyte production and chemotaxis upon inflammatory stimulation by tumor necrosis factor–α. [Sci Adv] Full Article

Interleukin-11 Regulates the Fate of Adipose-Derived Mesenchymal Stem Cells via STAT3 Signaling Pathways

Interleukin-11 promoted adipose-derived MSCs (ADSCs) proliferation, stimulated ADSC migration and attenuated ADSC apoptosis by activation of STAT3 signaling. [Cell Prolif] Full Article

DDX6 Helicase Behavior and Protein Partners in Human Adipose Tissue-Derived Stem Cells during Early Adipogenesis and Osteogenesis

Investigators characterized the protein complexes associated with DDX6 in human adipose tissue-derived stem cells and analyzed the dynamics of this helicase under different conditions of translational activity and differentiation. [Int J Mol Sci] Full Article

Human Platelet Lysate Can Replace Fetal Calf Serum as a Protein Source to Promote Expansion and Osteogenic Differentiation of Human Bone-Marrow-Derived Mesenchymal Stromal Cells

The proliferation rate of bone-marrow-derived mesenchymal stromal cells (BMSCs) cultured in expansion medium supplemented with human platelet lysate exceeded the proliferation rate of BMSCs cultured in the presence of fetal calf serum. [Cells] Full Article

IN VIVO

CD39 Produced from Human Gingiva-Derived MSC Regulates the Balance of Osteoclasts and Osteoblasts through Wnt/β-Catenin Pathway in Osteoporosis

Using an ovariectomized mouse model, the authors demonstrated that adoptive transfer of gingiva-derived MSCs regulated the balance of osteoclasts and osteoblasts, eventually contributing to dynamic bone formation. [Mol Ther] Abstract | Full Article | Graphical Abstract

Human Leukocyte Antigen Selected Allogeneic Mesenchymal Stromal Cell Therapy in Renal Transplantation: The Neptune Study, a Phase I Single-Center Study

Administration of HLA selected allogeneic MSCs combined with low dose tacrolimus six months after transplantation was safe at least in the first year after renal transplantation. [Am J Transplant] Abstract

TGF-β Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Ameliorates Atopic Dermatitis by Inhibiting Secretion of TNF-α and IgE

Scientists investigated the role of transforming growth factor‐beta (TGF-β) in the therapeutic effect of human umbilical cord blood-derived MSCs on atopic dermatitis. [Stem Cells] Abstract

Bone Marrow Mesenchymal Stem Cells Transplantation Alleviates Brain Injury after Intracerebral Hemorrhage in Mice through the Hippo Signaling Pathway

Researchers found that transplantation of bone marrow MSCs into the brains of mice could alleviated intracerebral hemorrhage-mediated injury and protected astrocytes from apoptosis by regulating mammalian sterile 20-like kinase 1 and Yes-associated protein. [Aging (Albany NY)] Full Article

Injectable Therapeutic Organoids Using Sacrificial Hydrogels

The authors introduced a method of using hydrogels as sacrificial scaffolds, which allowed cells to form self-organized clusters followed by gentle release, resulting in highly reproducible multicellular structures on a large scale. They demonstrated this strategy for endothelial cells and MSCs to self-organize into blood-vessel units, which were injected into mice, and rapidly formed perfusing vasculature. [iScience] Abstract | Full Article | Graphical Abstract

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Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

Preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. In this regard, MSC-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. [Stem Cell Rev Rep] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Hope Biosciences Receives Second FDA Clearance for a Phase II Clinical Trial for COVID-19

Hope Biosciences announced that FDA has approved a Phase II clinical trial evaluating the safety and efficacy of Hope Biosciences’ allogeneic, adipose-derived MSCs to provide immune support against COVID-19. [Hope Biosciences] Press Release

Orgenesis Announces Joint Venture Agreement with RevaTis to Produce Muscle-Derived Mesenchymal Stem Cells (mdMSCs) as a Source of Exosomes and Other Cellular Products for the Development of Related Therapies

Orgenesis Inc. announced a joint venture agreement with RevaTis S.A. The goal of the JV is to advance the development of autologous therapies, including in-licensed therapies through Orgenesis’s partners, utilizing and banking mdMSCs as a source of exosomes and other cellular products. [Orgenesis Inc.] Press Release

Pluristem Expands Its Compassionate Use Program: Treated First COVID-19 Patient in US Under FDA Single Patient Expanded Access Program

Pluristem Therapeutics Inc. announced that it has treated its first patient suffering from COVID-19 complications in the United States under the FDA Single Patient Expanded Access Program. [Pluristem Therapeutics Inc.] Press Release

How Scientists Can Volunteer to Help Fight COVID-19

Around the world, bench scientists other than those actively studying the pandemic have largely been forced to scale back or even shut down their experiments out of COVID-19 precautions. But that doesn’t mean their skills and expertise can’t contribute to the worldwide effort to address the disease. [The Scientist] Editorial

President of Europe’s Premier Science Funder Resigns amid Criticism That He Neglected Post

The president of Europe’s most prestigious funding agency has resigned suddenly after only three months in the post – prompting fiery accusations from the organization’s governing body that he largely neglected his responsibilities. [Nature News] Editorial

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NEW Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine)

Principal Investigator/Professor Positions – Stem Cell Research (Guangzhou Institutes of Biomedicine and Health)

PhD Student – Bioprinting of Tissues (Uppsala University)

Postdoctoral Positions – Systems Biology and Metabolism (Charité – Universitätsmedizin Berlin)

Postdoctoral Fellow – Biomaterials and Nanotechnology in Regenerative Medicine (Guangzhou Medical University)

Assistant Professor – Sarcoma (McGill University)

Professor – Molecular Physiology (Karolinska Institutet)

Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Osteoarthritis, Mechanobiology, and Regenerative Medicine (Oklahoma Medical Research Foundation)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

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