Mesenchymal Cell News 12.15 April 21, 2020 | |
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TOP STORYCombined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep The administration of human MSCs (hMSCs) did not improve oxygenation or pulmonary function. However, histological evidence of lung injury and BAL IL-8 were reduced. hMSC treated animals had a significantly lower cumulative requirement for vasopressor. [Am J Respir Crit Care Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROScientists revealed that MSC co-culture improved stemness and drug-resistance of gastric cancer cells. [Cell Death Dis] Full Article Ellipticine induced adipose-derived stem cells to differentiate into mature chondrocytes without hypertrophic chondrocytes in vitro and in vivo. [Exp Mol Med] Full Article Researchers found that glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid levels, was greatly upregulated by IFNγ and TNFα in human umbilical cord-derived MSCs in a synergistic manner. [Cell Death Discov] Full Article Leptin Acts on Mesenchymal Stem Cells to Promote Chemoresistance in Osteosarcoma Cells Using cell viability and apoptosis assays, investigators showed that medium conditioned by leptin-treated human MSCs promoted cisplatin resistance in cultured human osteosarcoma cells. [Aging (Albany NY)] Full Article Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional In Vitro Bone Model The authors investigated and optimized 3D culture conditions for macrophages, and then co-cultured macrophages with MSCs which were induced to undergo osteogenic differentiation to examine the effect of macrophages on new bone formation. [Tissue Eng Part A] Abstract The tenogenic differentiation induction capacity of the tenocyte replica in adipose tissue-derived MSCs was investigated and compared with other groups, including tissue replica, decellularized tendon, and bone morphogenic protein-12, as other potential inducers. [Biomed Mater] Full Article IN VIVOAdministration of MSCs overexpressing CREB1-NRF2 target genes alleviated graft-versus-host disease (GVHD) in a humanized mouse model, resulting in improved survival, decreased weight loss, and reduced histopathologic damages in GVHD target organs. [Sci Adv] Full Article Scientists investigated the effect and potential mechanism of MSCs against liver ischemia/reperfusion (I/R) injury. Effects of MSCs were studied in mice liver I/R injury model and in a hypoxia/reoxygenation model of L02 hepatocytes. [Cell Death Dis] Full Article Investigators showed that leukocytes and specifically polymorphonuclear neutrophils contributed to MSC-small extracellular vesicle-induced ischemic neuroprotection [Stroke] Abstract | Graphical Abstract Platelet-rich plasma application significantly enhanced the regeneration capacity of muscle-derived MSCs (M-MSCs) in a large bone defect via promoting the migration and proliferation of M-MSCs, and also inducing the osteogenic differentiation. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSThe authors provide an overview of cutaneous wound healing with discussion on how extracellular matrix proteins and hypoxia can be utilized to improve MSC retention and therapeutic outcome. [Am J Pathol] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSA single patient, emergency Investigational New Drug (IND) use was cleared by the FDA for the treatment of severe lung injury due to COVID-19 at the Providence Saint John’s Health Center, Santa Monica, CA with intravenous administration of ischemia-tolerant allogeneic mesenchymal bone marrow cells manufactured by Stemedica Cell Technologies, Inc. [Stemedica Cell Technologies, Inc.] Press Release Researchers at Queen’s University Belfast are leading a UK-wide clinical trial, offering an innovative cell therapy treatment for COVID-19 patients with acute respiratory failure. [Queen’s University Belfast] Press Release Wize Pharma, Inc. has initiated a preclinical study of its drug product candidate MesenCure, specifically developed to potentially treat acute and life-threatening respiratory distress and pneumonia whether as a result of infection with coronavirus (COVID-19), or any other type of virus, bacterial infection, or exposure to other contaminants. [Wize Pharma, Inc. (PR Newswire Association LLC.)] Press Release Predictive Biotech announced that it submitted an Emergency Use Authorization application with the FDA for the immediate use of MSCs derived from umbilical cord tissue for the treatment of acute respiratory distress syndrome, secondary to SARS-CoV-2, coronavirus disease 2019 (COVID-19). [Predictive Biotech] Press Release Creative Medical Technology Holdings Inc. announced receipt of a Quayle Action on its patent application #15/652213 entitled Methods for Treatment of Premature Ovarian Failure and Ovarian Aging using Regenerative Cells. [Creative Medical Technology Holdings Inc. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSHow Research Funders Are Tackling Coronavirus Disruption While science is crucial to the fight against COVID-19, researchers confined to their homes and unable to carry on with grant-funded work are becoming increasingly concerned about how the coronavirus pandemic will affect their funding. [Nature News] Editorial President Donald Trump said he will suspend US funding to the World Health Organization (WHO) pending a 60- to 90-day investigation into how the agency has handled the response to the COVID-19 pandemic. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Principal Investigators and Postdoctoral Fellows – Cell Biology (Fudan University) Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine) PhD Student – Bioprinting of Tissues (Uppsala University) Postdoctoral Positions – Systems Biology and Metabolism (Charité – Universitätsmedizin Berlin) Assistant Professor – Sarcoma (McGill University) Professor – Molecular Physiology (Karolinska Institutet) Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine) Postdoctoral Associate – Cartilage Regeneration (Drexel University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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