Mesenchymal Cell News 12.16 April 28, 2020 | |
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TOP STORYResearchers present a microfabrication approach in which a combination of reactive ion etching protocols was used to produce high-aspect-ratio, nondegradable silicon nanoneedle arrays with tip diameters that could be finely tuned between 20 and 700 nm. They used these arrays to guide the long-term culture of human MSCs. [ACS Nano] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROCell-Cell Adhesion Driven Contact Guidance and Its Effect on hMSC Differentiation The authors engineered a set of microstrip patterns of cell-cell adhesion ligands and segregated cell-cell and cell-matrix ligands, as a simple yet versatile set of platforms for the guidance of spreading, adhesion, and differentiation of MSCs. [ACS Appl Mater Interfaces] Abstract Scientists showed that bone morphogenic proteins (BMPs) and long-term osteogenic signals in MSCs selectively induced expression of polybromo BAF components Pbrm1, Arid2, and Brd7. Loss of Pbrm1/Arid2/Brd7 profoundly impaired osteolineage gene expression and osteogenesis without compromising adipogenesis. [Cell Rep] Full Article | Graphical Abstract Investigators evaluated the role of hypoxia‐inducible factor 1 α (HIF1α) on MSC immunosuppressive potential. They showed that HIF1α silencing in MSC decreased their inhibitory potential on Th1 and Th17 cell generation and limited their capacity to generate regulatory T cells. [FASEB J] Full Article Researchers designed a biomimetic niche comprising insoluble fibrin supported adhesion matrix and exogenously added growth factors (GFs) for deriving different neural cells and established the role of notch and Wnt signals for proliferation and differentiation of adipose-derived MSCs, respectively. [Sci Rep] Full Article Investigators demonstrated the presence of human Hv1 (hHv1) in the placenta/chorion-derived MSCs using RT-PCR. The voltage- and pH-dependent gating of the current was similar to that of hHv1 expressed in cell lines and that the current was blocked by 5-chloro-2-guanidinobenzimidazole and activated by arachidonic acid. [Sci Rep] Full Article IN VIVODextran sulfate sodium (DSS)-induced colitic mice treated with adipose-derived MSCs (aMSCs) showed significant reduction in their colitic disease activity index during the second DSS challenge when compared to non-aMSC-treated DSS-induced colitic mice. [J Crohns Colitis] Full Article Researchers showed that exosomes from osteonecrosis of the femoral head (ONFH) bone tissues were able to induce GC-induced ONFH-like damage, in vivo and impair osteogenic differentiation and migration of MSCs, in vitro. [Cell Death Dis] Full Article The authors demonstrated that human umbilical cord MSC-derived exosomes had a treatment capability for Parkinson’s disease and could traverse the blood-brain barrier. [Cell Death Dis] Full Article Human umbilical cord-derived MSCs (hUC-MSCs) inhibited schizophrenia-relevant and the neuroinflammatory changes. The main mechanism of hUC-MSCs was associated with the induction of Tregs and production of the anti-inflammatory cytokine, IL-10, in periphery. [Transl Psychiatry] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSMSC-derived extracellular vesicles may exhibit substantial therapeutic properties in many pathophysiological conditions, potentially restoring an extensive range of damaged or diseased tissues and organs. [Cells] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSUM Offers Stem Cells to Treat COVID-19 Patients with Life-Threatening Respiratory Infections For COVID-19 patients in severe respiratory distress, the University of Miami Miller School of Medicine (UM) now offers access to MSC treatments that may help fight the characteristic inflammation that accompanies the viral infection. [University of Miami Miller School of Medicine] Press Release Citius Pharmaceuticals, Inc. announced that it submitted a pre-IND meeting request and supporting briefing documents to the Center for Biologics Evaluation and Research of the FDA under the Coronavirus Treatment Acceleration Program. [Citius Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSOpen Science Takes On the Coronavirus Pandemic When reports emerged in late 2019 of an outbreak of a new coronavirus centred in Wuhan, China, researchers at the virological-analysis website Nextstrain were ready. The open-source project tracks the spread of viruses through genetic variations in the sequences that scientists find. [Nature News] Editorial Untapped Potential: More US Labs Could Be Providing Tests for Coronavirus A survey of more than 4,000 researchers in the United States suggests that better coordination at an institutional and national level could make hundreds of thousands more tests for coronavirus available. [Nature News] Editorial
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JOB OPPORTUNITIESNEW Research Group Leaders – Structural Biology Research Centre (Fondazione Human Technopole) Principal Investigators and Postdoctoral Fellows – Cell Biology (Fudan University) Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine) PhD Student – Bioprinting of Tissues (Uppsala University) Postdoctoral Positions – Systems Biology and Metabolism (Charité – Universitätsmedizin Berlin) Assistant Professor – Sarcoma (McGill University) Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine) Postdoctoral Associate – Cartilage Regeneration (Drexel University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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