Mesenchymal Cell News 12.20 May 26, 2020 | |
| |
TOP STORYSensory Nerves Regulate Mesenchymal Stromal Cell Lineage Commitment by Tuning Sympathetic Tones Scientists found that after sensory denervation, knockout of the EP4 receptor in sensory nerves, or knockout of COX-2 in osteoblasts, could significantly promote adipogenesis and inhibit osteogenesis in adult mice. [J Clin Invest] Full Article | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers revealed that the α4 integrin subunit on myeloma cells stimulated vascular cell adhesion molecule–1 (VCAM1) on MSCs, leading to the activation of protein kinase C β1 signaling and repression of the muscle ring-finger protein-1 (MURF1)-mediated ubiquitylation of peroxisome proliferator–activated receptor γ2. [Sci Signal] Full Article Subjecting MSCs to serum deprivation led to significant increase in cell spread area and cell-matrix adhesion. An upregulation of vitronectin expression was noted with an arrest in G0/G1 phase of cell cycle and no appreciable apoptotic change. [Stem Cell Res Ther] Full Article Investigators selected placentas from 35 informed donors and exploited three commonly used methods. MSCs were isolated from different parts of placental tissue including umbilical cord, amniotic membrane, chorionic membrane, chorionic villi, and deciduae. [Stem Cell Res Ther] Full Article As a proof-of-principle, MSCs were encapsulated and their small extracellular vesicle (sEV) release rate was monitored throughout the culture and compared to sEV isolated from 2D seeded cells by repetitive ultracentrifugation cycles or a commercial kit. [Front Pharmacol] Full Article Kartogenin appeared to have weak chondrogenic potency in human bone marrow MSCs cultures relative to TGF-β1, did not obstruct hypertrophy, and may not be a viable alternative to growth factors in cartilage tissue engineering. [Sci Rep] Full Article Human adipose MSCs treated with bone morphogenetic protein 7 (BMP7)-soybean lecithin‐P34HB nanoparticles (SPNPs) showed higher ALP activity and higher expression levels of genetic markers of osteogenic differentiation compared to the control group. [J Tissue Eng Regen Med] Abstract IN VIVOScientists examine the effect of CCR3 antagonist (CCR3A) on cellular senescence and anti-inflammation/immunomodulation in human periodontal ligament cells (HPDLCs). The rejuvenating effects of CCR3A on neurite extension and migratory activity to promote pulp regeneration in aged dog teeth were also evaluated. [Sci Rep] Full Article H19 had no significant effect on the proliferative behaviors of human bone marrow MSCs (HBMSCs), while its overexpression of H19 in human amnion-derived MSCs led to the upregulated osteogenesis of HBMSCs in vivo and in vitro; whereas its knockdown reversed these effects. [Aging (Albany NY)] Full Article Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
| |
REVIEWSWhile the need for MSC therapy in COVID-19 is apparent, integrating both innate and adaptive immune compatibility testing into the current guidelines for cell, tissue, and organ transplantation is critical for safe and effective therapies. [Front Immunol] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
| |
POLICY NEWSOpen-Access Science Funders Announce Price Transparency Rules for Publishers Science journals will have to disclose the costs of publishing articles in order for them to be paid for by a coalition of research funders pushing for open access. [ScienceInsider] Editorial US Lawmakers Unveil Bold $100 Billion Plan to Remake NSF The National Science Foundation (NSF) would get a sweeping remake-including a new name, a huge infusion of cash, and responsibility for maintaining US global leadership in innovation-under bipartisan bills that have been introduced in both houses of Congress. [ScienceInsider] Editorial
| |
EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Researcher – Human Tissue (Fondazione Banca dei Tessuti di Treviso Onlus) NEW Senior Investigator – Stem Cell Biology (Institut Pasteur of Shanghai) NEW Postdoctoral Fellow – In Vivo Molecular and Cellular Imaging (Johns Hopkins University) Postdoctoral Position – Bone Biology (Karolinska Institutet) Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine) Principal Investigators and Postdoctoral Fellows – Cell Biology (Fudan University) Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine) Postdoctoral Positions – Systems Biology and Metabolism (Charité – Universitätsmedizin Berlin) Postdoctoral Associate – Cartilage Regeneration (Drexel University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|