Mesenchymal Cell News Volume 12.23 | Jun 16 2020

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    MESCN 12.23 | June 16 2020

    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.23 – 16 June, 2020
    TOP STORY

    Characterization of a Pluripotent Stem Cell-Derived Matrix with Powerful Osteoregenerative Capabilities

    The authors describe a highly osteogenic MSC line generated from induced pluripotent stem cells that generated high yields of an osteogenic cell-matrix in vitro.
    [Nature Communications]

    Full Article

    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    PUBLICATIONSRanked by the impact factor of the journal

    Synthesis and Characterization of Silk Ionomers for Layer-By-Layer Electrostatic Deposition on Individual Mammalian Cells

    Through the optimization of material properties and composition of incubation buffers, silk ionomers could be electrostatically assembled on the surface of murine fibroblasts and human mesenchymal stem cells to form nanoscale multilayers without significantly impairing cell viability.
    [Biomacromolecules]

    Abstract

    Direct Incorporation of Mesenchymal Stem Cells into a Nanofiber Scaffold – In Vitro and In Vivo Analysis

    Stem cells isolated from rat femora were incorporated into poly-l-lactide acid (PLLA) and PLLA-collagen type-I nanofiber scaffolds via simultaneous electrospinning and spraying.
    [Scientific Reports]

    Full Article

    Heat Treatment Dependent Cytotoxicity of Silicalite-1 Films Deposited on Ti-6Al-4V Alloy Evaluated by Bone-Derived Cells

    Two types of bone-derived cells were used for a biocompatibility assessment. While no increase in cell membrane damage, in ROS generation and in TNF-alpha secretion of bone-derived cells grown on both silicalite-1 films was found.
    [Scientific Reports]

    Full Article

    Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer

    A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
    [Macromolecular Bioscience]

    Full Article

    Human Umbilical Cord Blood-Derived MSC Exosomes Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

    Overexpression of divalent metal transporter 1 (DMT1) promoted H/R-induced myocardial cell ferroptosis, while knockdown of DMT1 significantly inhibited the ferroptosis.
    [Cell Biology and Toxicology]

    Abstract

    Canonical Notch Signaling Is Required for Bone Morphogenetic Protein‐Mediated Human Osteoblast Differentiation

    Systemic Notch inhibition using diabenzazepine reduced bone morphogenetic protein (BMP)2-induced calvarial bone healing in mice supporting the critical regulatory role of Notch signaling in BMP-induced osteoblastogenesis.
    [Stem Cells]

    Abstract

    Bobby Sox Homolog Regulates Tooth Root Formation through Modulation of Dentin Sialophosphoprotein

    Investigators generated bobby sox homolog (Bbx) knockout mice to address the functional role of Bbx in tooth formation. During tooth development, Bbx was expressed in both dental epithelium and mesenchyme.
    [Journal of Cellular Physiology]

    Abstract

    Bushenhuoxue Formula Accelerates Fracture Healing via Upregulation of TGF-β/Smad2 Signaling in Mesenchymal Progenitor Cells

    Researchers performed unilateral open transverse tibial fracture procedure in C57BL/6 mice which were treated with or without Bushenhuoxue formula.
    [Phytomedicine]

    Full ArticleGraphical Abstract

    Gaucher Disease-Associated Alterations in Mesenchymal Stem Cells Reduce Osteogenesis and Favor Adipogenesis Processes with Concomitant Increased Osteoclastogenesis

    Researchers evaluated the process of osteoclastogenesis and observed that conditioned media from Gaucher disease MSCs supernatants induced an increase in the number of osteoclasts.
    [Molecular Genetics and Metabolism]

    Abstract

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    REVIEWS

    Skull Base Chordomas and Chondrosarcomas

    Chordomas and chondrosarcomas are not sensitive to chemotherapy and there are no approved drugs for their treatment. The present treatment concept is a combination of surgical resection with a maximal excision and preserving patients’ quality of life by adjuvant radiotherapy for both, chordomas and chondrosarcomas.
    [Neuroendocrinology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Hong Kong’s Contentious National Security Law Concerns Some Academics

    China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
    [Nature News]

    Editorial

    Huge Open-Access Journal Deal Inked by University of California and Springer Nature

    The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
    [ScienceInsider]

    Editorial

    CyMedica Orthopedics Completes e-vive Parent Clinical Trial for Management of Knee Osteoarthritis Pain

    CyMedica Orthopedics announced that it completed early enrollment of 159 patients in the FDA-regulated clinical trial of their e-vive technology for pain relief in patients with knee osteoarthritis.
    [CyMedica Orthopedics]

    Press Release

    FEATURED EVENT

    International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs

    2020-10-12 – 2020-10-14
    Paris, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Mesenchymal Neoplasms

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Position – Cellular Stress Signaling

    University of Copenhagen – Copenhagen, Denmark

    Researcher – Human Tissue

    Fondazione Banca dei Tessuti di Treviso Onlus – Treviso, Italy

    Senior Investigator – Stem Cell Biology

    Institut Pasteur of Shanghai – Shanghai, China

    Postdoctoral Fellow – In Vivo Molecular and Cellular Imaging

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Fellow – Cell Biology

    Tulane University School of Medicine – New Orleans, Louisiana, United States

    Postdoctoral Position – Bone Development

    KU Leuven – Leuven, Belgium

    Postdoctoral Position – Regeneration of Diseased Bone

    Radboud umc – Nijmegen, Netherlands

    > See All Jobs

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