 | | Vol. 12.24 – 23 June, 2020 |
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| Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
[Aging Cell] |
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| Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease] |
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| Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity, mineralization ability, and gene expression of osteogenic makers.
[International Journal of Oral Science] |
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| The authors investigated whether damage-induced transforming growth factor β signaling impaired the expression and function of T-cell factor 4, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors.
[Journal of Cell Science] |
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| Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
[Laboratory investigation] |
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| Investigators report the ability of a scalable hollow fiber bioreactor to effectively maintain ideal mesenchymal stem cell function as a single population while also being able to impart an immunoregulatory effect when cultured in tandem with an inflamed lymphocyte population.
[Scientific Reports] |
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| Scientists found that across three human MSC donors, MSCs increased their expression of indoleamine-2,3-dioxygenase in response to both increased dose of IFNγ and duration of pre-licensing.
[Journal of the Royal Society interface] |
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| | While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
[Nature Communications] |
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| Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences] |
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| Investigators provided in vivo evidence that Runx2 played a crucial role in tooth root development and in regulating the differentiation of root progenitor cells.
[Journal of Bone and Mineral Research] |
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| The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discuss the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
[Bone Research] |
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| Ultragenyx Pharmaceutical, Inc. and Kyowa Kirin Co., Ltd. announced that the FDA has approved Crysvita® for the treatment of fibroblast growth factor 23-related hypophosphatemia in tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized in adults and pediatric patients two years of age and older.
[Ultragenyx Pharmaceutical, Inc.] |
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| With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News] |
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| Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist] |
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| 2020-07-16 – 2020-07-17
Virtual |
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| | Genezen Laboratories – Indianapolis, Indiana, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Genezen Laboratories – Indianapolis, Indiana, United States |
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| | KU Leuven – Leuven, Belgium |
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| | Radboud umc – Nijmegen, Netherlands |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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Neural Cell News
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