Mesenchymal Cell News Volume 12.25 | Jun 30 2020

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    MESCN Volume 12.25 | Jun 30

    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.25 – 30 June, 2020
    TOP STORY

    New Insights into Molecular and Cellular Mechanisms of Zoledronate in Human Osteosarcoma

    The authors provide the available literature on in vitro studies to illustrate the new insights into the intracellular molecular mechanisms of zoledronate in human osteosarcoma cell lines.
    [Pharmacology & Therapeutics]

    Review

    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    LncRNA ENST00000563492 Promoting the Osteogenesis-Angiogenesis Coupling Process in Bone Mesenchymal Stem Cells (BMSCs) by Functions as a ceRNA for miR-205-5p

    Investigators found that lncRNA ENST00000563492 was downregulated in bone nonunion tissues. LncRNA ENST00000563492 promoted osteogenic differentiation of BMSCs through upregulating the expression of CDH11.
    [Cell Death & Disease]

    Full Article

    Peripheral Blood As a Source of Stem Cells for Regenerative Medicine: Emphasis towards Corneal Epithelial Reconstruction – An In Vitro Study

    Rabbit peripheral blood-derived mononuclear cells were isolated using density gradient centrifugation and was evaluated for mesenchymal cell properties including stemness.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    Effect of Donor Age and 3D-Cultivation on Osteogenic Differentiation Capacity of Adipose-Derived Mesenchymal Stem Cells

    Alkaline phosphatase (ALP) activity revealed highest levels in 3D of old adipose-derived MSCs after 14 days. ALP expression showed significant rises in old versus young cells in 2D.
    [Scientific Reports]

    Full Article

    RNA-Sequencing Reveals Positional Memory of Multipotent Mesenchymal Stromal Cells from Oral and Maxillofacial Tissue Transcriptomes

    Scientists isolated and characterized human MSCs from three different bones, maxilla and mandible and proceeded with next generation RNA-sequencing.
    [BMC Genomics]

    Full Article

    miR-200b in Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviates Inflammatory Injury of Intestinal Epithelial Cells by Targeting High Mobility Group Box 3

    Researchers identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreased the inflammatory injury.
    [Cell Death & Disease]

    Full Article

    Cutaneous Wound Healing: Canine Allogeneic ASC Therapy

    The percentage of the wounds that exhibited contraction and re-epithelialization were significantly different between wounds treated with adipose mesenchymal stem cells and control wounds.
    [Stem Cell Research & Therapy]

    Full Article

    G-CSF Inhibits Pulmonary Fibrosis by Promoting BMSC Homing to the Lungs via SDF-1/CXCR4 Chemotaxis

    Investigators found that bone marrow mesenchymal stem cells could inhibit fibroblast proliferation and transdifferentiation into myofibroblasts through paracrine actions.
    [Scientific Reports]

    Full Article

    Effect of Aging and 5-Fluorouracil Treatment on Bone Marrow Stem Cell Dynamics

    CD44 positive aged MSCs showed increased proliferation on D10. Transplanting MSCs from young mice in 5-Fluorouracil treated aged marrow helped improve hematopoiesis.
    [Stem Cell Reviews and Reports]

    Abstract

    miR-132-3p Priming Enhances the Effects of Mesenchymal Stromal Cell-Derived Exosomes on Ameliorating Brain Ischemic Injury

    Mesenchymal stromal cell-derived exosomes could deliver their carried miR-132-3p into target ECs, which functionally downregulated the target protein RASA1, while upregulated the expression of Ras and the downstream PI3K phosphorylation.
    [Stem Cell Research & Therapy]

    Full Article

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    REVIEWS

    Facts and Hopes in Immunotherapy of Soft Tissue Sarcomas

    The authors focus on the role of the immune microenvironment in the development and activity of new therapeutic approaches, and the recent identification of the sarcoma immune class (SIC) groups, especially group SIC E with its B cell signature that predicts immunotherapy response.
    [Clinical Cancer Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    Citius Receives FDA Response on Pre-Investigational New Drug (PIND) Application for its Induced Mesenchymal Stem Cells (iMSCs) to Treat Acute Respiratory Distress Syndrome (ARDS) in Patients with COVID-19

    Citius Pharmaceuticals, Inc. announced that the Company has received a written response from the FDA in regards to its pre-investigational new drug application for its induced mesenchymal stem cells to treat and reduce the severity of acute respiratory distress syndrome in patients with COVID-19.
    [Citius Pharmaceuticals, Inc. (PR Newswire Association LLC.)]

    Press Release

    NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

    On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
    [Nature News]

    Editorial

    FEATURED EVENT

    Life Science Innovation Northwest Conference

    July 16 – July 17
    Virtual

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    JOB OPPORTUNITIES

    Scientific Project Manager – Tissue Engineering and Regenerative Medicine

    Helmholtz Zentrum München – Neuherberg, Germany

    Senior Scientist – Process Development Lab, Gene and Cell Therapy

    Genezen Laboratories – Indianapolis, Indiana, United States

    Postdoctoral Fellow – Mesenchymal Neoplasms

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Position – Bone Development

    KU Leuven – Leuven, Belgium

    Postdoctoral Position – Regeneration of Diseased Bone

    Radboud umc – Nijmegen, Netherlands

    > See All Jobs

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