| Vol. 12.25 – 30 June, 2020 |
| |
|
|
| The authors provide the available literature on in vitro studies to illustrate the new insights into the intracellular molecular mechanisms of zoledronate in human osteosarcoma cell lines. [Pharmacology & Therapeutics] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Investigators found that lncRNA ENST00000563492 was downregulated in bone nonunion tissues. LncRNA ENST00000563492 promoted osteogenic differentiation of BMSCs through upregulating the expression of CDH11. [Cell Death & Disease] |
|
|
|
| Rabbit peripheral blood-derived mononuclear cells were isolated using density gradient centrifugation and was evaluated for mesenchymal cell properties including stemness. [Journal of Tissue Engineering and Regenerative Medicine] |
|
|
|
| Alkaline phosphatase (ALP) activity revealed highest levels in 3D of old adipose-derived MSCs after 14 days. ALP expression showed significant rises in old versus young cells in 2D. [Scientific Reports] |
|
|
|
| Scientists isolated and characterized human MSCs from three different bones, maxilla and mandible and proceeded with next generation RNA-sequencing. [BMC Genomics] |
| |
|
|
| Researchers identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreased the inflammatory injury. [Cell Death & Disease] |
|
|
|
| The percentage of the wounds that exhibited contraction and re-epithelialization were significantly different between wounds treated with adipose mesenchymal stem cells and control wounds. [Stem Cell Research & Therapy] |
|
|
|
| Investigators found that bone marrow mesenchymal stem cells could inhibit fibroblast proliferation and transdifferentiation into myofibroblasts through paracrine actions. [Scientific Reports] |
|
|
|
| CD44 positive aged MSCs showed increased proliferation on D10. Transplanting MSCs from young mice in 5-Fluorouracil treated aged marrow helped improve hematopoiesis. [Stem Cell Reviews and Reports] |
|
|
|
| Mesenchymal stromal cell-derived exosomes could deliver their carried miR-132-3p into target ECs, which functionally downregulated the target protein RASA1, while upregulated the expression of Ras and the downstream PI3K phosphorylation. [Stem Cell Research & Therapy] |
|
|
|
|
| The authors focus on the role of the immune microenvironment in the development and activity of new therapeutic approaches, and the recent identification of the sarcoma immune class (SIC) groups, especially group SIC E with its B cell signature that predicts immunotherapy response. [Clinical Cancer Research] |
|
|
|
|
| Citius Pharmaceuticals, Inc. announced that the Company has received a written response from the FDA in regards to its pre-investigational new drug application for its induced mesenchymal stem cells to treat and reduce the severity of acute respiratory distress syndrome in patients with COVID-19. [Citius Pharmaceuticals, Inc. (PR Newswire Association LLC.)] |
|
|
|
| On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs. [Nature News] |
|
|
|
|
| July 16 – July 17 Virtual |
|
|
|
|
|
| Helmholtz Zentrum München – Neuherberg, Germany | |
|
|
|
| Genezen Laboratories – Indianapolis, Indiana, United States |
|
|
|
| Memorial Sloan Kettering Cancer Center – New York, New York, United States |
|
|
|
| KU Leuven – Leuven, Belgium |
|
|
|
| Radboud umc – Nijmegen, Netherlands |
|
|
|
|