Mesenchymal Cell News Volume 12.26 | July 7 2020

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Volume 12.26 | Jul 7
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Vol. 12.26 – 7 July, 2020 TOP STORY Activating PIK3CA Mutation Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells in Macrodactyly Activating PIK3CA mutations and activation of PI3K/AKT/mTOR pathway were detected in all macrodactyly-derived bone marrow mesenchymal stem cells (MAC-BMSCs). MAC-BMSCs had enhanced osteogenesis potential compared with polydactyly-derived-BMSCs. [Cell Death & Disease] Full Article PUBLICATIONSRanked by the impact factor of the journal IN VITRO Allogeneic Adipose-Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF -1α/IL -10 Pathway Scientists found that the ability of RAW264.7 cells to migrate was impaired in hypoxia, whereas coculturing with adipose‐derived mesenchymal stem cells could enhance the migration capacity. [Stem Cells] Abstract Lysophosphatidic Acid Modulates Ovarian Cancer Multicellular Aggregate Assembly and Metastatic Dissemination The functional consequence was an lysophosphatidic acid-induced dissemination of small mesenchymal-type clusters, promoting a miliary mode of peritoneal seeding that complicated surgical removal and was associated with worse prognosis. [Scientific Reports] Full Article Effect of Echinalkamide Identified from Echinacea purpurea (L.) Moench on the Inhibition of Osteoclastogenesis and Bone Resorption Among three new compounds, echinalkamide had considerable inhibitory effects on RANKL-induced osteoclast differentiation, and on proliferation of osteoclasts and efficiently attenuated osteoclastic bone resorption without toxicity. [Scientific Reports] Full Article Bone Marrow Stromal Cells-Derived microRNA-181-Containing Extracellular Vesicles Inhibit Ovarian Cancer Cell Chemoresistance by Downregulating MEST via the Wnt/β-Catenin Signaling Pathway Extracellular vesicles (EVs) were isolated from bone marrow stromal cells (BMSCs) and co-cultured with ovarian cancer cells to further investigate the effects of overexpressed miR-181 delivered by BMSCs-derived EVs on ovarian cancer cell resistance to cisplatin. [Cancer Gene Therapy] Abstract Functional Changes in Decidual Mesenchymal Stem/Stromal Cells are Associated with Spontaneous Onset of Labor Decidual MSCs displayed stem cell-like properties and were of maternal origin. Important cell properties and lipid profiles were assessed and compared between spontaneous onset of labor- and not in labor-decidual MSCs. [Molecular Human Reproduction] Abstract IN VIVO Exosomes Derived from Human Placental Mesenchymal Stromal Cells Carrying miR-4450 Inhibitor Alleviate Intervertebral Disc Degeneration and Ameliorate Gait Disturbances via Up-Regulation of ZNF121 The authors revealed that miR-4450 was highly expressed, while ZNF121 was poorly expressed in intervertebral disc degeneration patients and nucleus pulposus cells treated with TNF-α. [Stem Cells and Development] Abstract Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-Like Vasculopathy in Klf5+/-; Fli1+/- Mice Neovascularization and angiogenesis were assessed by in vivo Matrigel plug assay and in vitro tube formation assay, respectively. [Arthritis & Rheumatology] Abstract Synovial Cell Cross-Talk with Cartilage Plays a Major Role in the Pathogenesis of Osteoarthritis Intact cartilage was enriched for homeostatic and hypertrophic chondrocytes, while damaged cartilage was enriched for prefibro- and fibro-, regulatory, reparative and prehypertrophic chondrocytes. [Scientific Reports] Full Article REVIEWS Alternative Splicing in Mesenchymal Stem Cell Differentiation The authors highlight the key alternative splicing (AS) events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated. [Stem Cells] Abstract INDUSTRY AND POLICY NEWS Celltex Therapeutics Receives Another FDA Approval: Phase II Clinical Trial Using Mesenchymal Stem Cells (MSCs) as a Prophylactic against COVID-19 Celltex announced that it has received approval from the FDA to proceed with the Company’s investigational new drug application to investigate the prophylactic efficacy of autologous adipose tissue-derived mesenchymal stem cells against COVID-19. [Celltex] Press Release An Optimist Takes the Helm at the National Science Foundation The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists – who make up a sizeable share of the US research enterprise – to enter the country. [Science] Editorial FEATURED EVENT Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy? July 9 Virtual > See All Events JOB OPPORTUNITIES Postdoctoral Position – Bone and Stem Cell Research University of Connecticut Health – Farmington, Connecticut, United States Scientific Project Manager – Tissue Engineering and Regenerative Medicine Helmholtz Zentrum München – Neuherberg, Germany Senior Scientist – Process Development Lab, Gene and Cell Therapy Genezen Laboratories – Indianapolis, Indiana, United States Postdoctoral Fellow – Mesenchymal Neoplasms Memorial Sloan Kettering Cancer Center – New York, New York, United States Postdoctoral Position – Bone Development KU Leuven – Leuven, Belgium > See All Jobs Brought to you by Connexon Creative Mesenchymal Cell News Archives Contact Us

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Activating PIK3CA Mutation Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells in Macrodactyly
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Activating PIK3CA mutations and activation of PI3K/AKT/mTOR pathway were detected in all macrodactyly-derived bone marrow mesenchymal stem cells (MAC-BMSCs). MAC-BMSCs had enhanced osteogenesis potential compared with polydactyly-derived-BMSCs.
[Cell Death & Disease]

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Activating PIK3CA Mutation Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells in Macrodactyly
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