Mesenchymal Cell News Volume 12.27 | July 14 2020

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    MESCN 12.27 | July 14 2020


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.27 – 14 July, 2020
    TOP STORY

    Single-Cell RNA Sequencing Reveals Profibrotic Roles of Distinct Epithelial and Mesenchymal Lineages in Pulmonary Fibrosis

    The authors report that a remarkable shift in epithelial cell phenotypes occured in the peripheral lung in pulmonary fibrosis and identified several previously unrecognized epithelial cell phenotypes.
    [Science Advances]

    Full Article

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    Stem Cell Derived Extracellular Vesicles for Vascular Elastic Matrix Regenerative Repair

    Scientists investigated the unknown effects of bone marrow derived mesenchymal stem cells derived extracellular vesicles on vascular elastic matrix repair in the context of abdominal aortic aneurysms treatment.
    [Acta Biomaterialia]

    Abstract

    Transamniotic Mesenchymal Stem Cell Therapy for Neural Tube Defects Preserves Neural Function through Lesion-Specific Engraftment and Regeneration

    Researchers report that transamniotic bone marrow-derived mesenchymal stem cell therapy for neural tube defects during early development may achieve beneficial functional recovery.
    [Cell Death & Disease]

    Full Article

    The Osteogenic Commitment of CD271+CD56+ Bone Marrow Stromal Cells (BMSCs) in Osteoarthritic Femoral Head Bone

    Researchers utilized cell sorting and immunohistochemistry to identify a phenotypically-distinct, osteogenically-committed bone marrow stromal cell subset in human osteoarthritis trabecular bone.
    [Scientific Reports]

    Full Article

    PPARβ/δ-Dependent MSC Metabolism Determines Their Immunoregulatory Properties

    Investigators demonstrated that PPARβ/δ deficiency forced MSC metabolic adaptation increasing their glycolytic activity required for their immunoregulatory functions on Th1 and Th17 cells.
    [Scientific Reports]

    Full Article

    Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell

    Effects of umbilical cord-mesenchymal stem cell-conditioned medium on insulin resistance were evaluated using glucose uptake, glucose transporter type 4 translocation, the insulin-signaling pathway, and mitochondrial contents and functions in C2C12 cell.
    [Diabetes & Metabolism Journal]

    Full Article

    Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

    Investigators report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor.
    [Molecular Therapy]

    Full Article

    Combinational Therapy with Antibiotics and Antibiotic-Loaded Adipose-Derived Stem Cells Reduce Abscess Formation in Implant-Related Infection in Rats

    Scientists evaluated the antimicrobial activity and therapeutic effect of local treatment with antibiotic-loaded adipose-derived stem cells plus an antibiotic in a rat implant-associated infection model.
    [Scientific Reports]

    Full Article


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    REVIEWS

    Mesenchymal Stem Cell Derived Exosomes: A Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19

    With an urgent need for the development of potential strategies, two recent studies from China using MSCs to treat COVID-19 pneumonia have shed some light on a potential cure for the COVID-19 infected patients.
    [Stem Cell Reviews and Reports]

    Full Article

    INDUSTRY AND POLICY NEWS

    How Scientific Societies Are Weathering the Pandemic’s Financial Storm

    As meetings worldwide have been called off, postponed or moved online because of the pandemic, organizations are trying to weather the cost of cancelling meetings while grappling with the long-term effects that the pandemic could have on their activities and on the research community.
    Editorial

    ‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

    A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
    [Science]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Position – Bone and Stem Cell Research

    University of Connecticut Health – Farmington, Connecticut, United States

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    Helmholtz Zentrum München – Neuherberg, Germany

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    Genezen Laboratories – Indianapolis, Indiana, United States

    Postdoctoral Fellow – Mesenchymal Neoplasms

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Position – Bone Development

    KU Leuven – Leuven, Belgium

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