Mesenchymal Cell News Volume 12.29 | Jul 28 2020

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    2020-07-28 | MESCN 12.29


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.29 – 28 July, 2020
    TOP STORY

    Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhance Angiogenesis In Vivo at a Low-Cell Dose

    Researchers demonstrated the biophysical and biochemical effects of preconditioning human mesenchymal stem cells for 96 hours on a three-dimensional extracellular matrix-based microgel platform.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway

    When co-culturing osteosarcoma (OS) cells with bone marrow-derived mesenchymal stem cells (BMSCs) in vitro, scientists validated that oncogenic LCP1 in OS was transferred from BMSCs via exosomes.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    Ryk Modulates the Niche Activity of Mesenchymal Stromal Cells by Fine-Tuning Canonical Wnt Signaling

    The authors found that Ryk—an atypical Wnt receptor with a pseudokinase domain—had a Wnt-modulating effect in bone marrow stromal cells to control hematopoiesis-supporting activities.
    [Experimental and Molecular Medicine]

    Full Article

    Renal Progenitor Cells Have Higher Genetic Stability and Lower Oxidative Stress than Mesenchymal Stem Cells during In Vitro Expansion

    Investigators evaluated the evolution of genetic stability, viability, and oxidative stress of bone marrow mesenchymal stem cells and renal progenitor cells of the renal cortex of swine in culture passages.
    [Oxidative Medicine and Cellular Longevity]

    Full Article

    Overexpression of Pigment Epithelium-Derived Factor in Placenta-Derived Mesenchymal Stem Cells Promotes Mitochondrial Biogenesis in Retinal Cells

    Researchers overexpressed pigment epithelium-derived factor (PEDF) in placenta-derived mesenchymal stem cells (PD-MSCsPEDF) using a nonviral gene delivery system and evaluated the characteristics of PD-MSCsPEDF and their potential regenerative effects on retinal pigment epithelial cells damaged by H2O2-induced oxidative stress.
    [Laboratory Investigation]

    Abstract

    Pulp Regeneration with Hemostatic Matrices as a Scaffold in an Immature Tooth Minipig Model

    Cell viability of human dental pulp stem cells cultured three-dimensionally in gelatin-based and fibrin-based scaffolds was evaluated by MTT and live/dead assay.
    [Scientific Reports]

    Full Article

    Pro-Angiogenic Scaffold-Free Bio Three-Dimensional Conduit Developed from Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration

    Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
    [Scientific Reports]

    Full Article

    Glucocorticoid Priming of Nonviral Gene Delivery to Human Mesenchymal Stem Cells Increases Transfection by Reducing Induced Stresses

    Scientists showed that transgene expression enhancement was mediated by transcriptional activation of endogenous human MSC genes by the cytosolic glucocorticoid receptor.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract

    Conversion of Neural Stem Cells into Functional Neuron-Like Cells by MicroRNA-218: Differential Expression of Functionality Genes

    Adipose-derived MSC were converted into neural stem cells (NSC) via neurosphere. The resulting NSC were then differentiated into neuron-like cells by transduction with microRNA-218, using a lentiviral vector.
    [Neurotoxicity Research]

    Abstract

    Intranasal Delivery of Mesenchymal Stem Cell Secretome Repairs the Brain of Alzheimer’s Mice

    Researchers demonstrated that in vivo systemic administration of secretome collected from MSC exposed in vitro to Alzheimer’s disease (AD) mouse brain homogenates, fully replicated the cell-mediated neuroreparative effects in APP/PS1 AD mice.
    [Cell Death & Differentiation]

    Full Article

    Loss of p53 in Mesenchymal Stem Cells Promotes Alteration of Bone Remodeling through Negative Regulation of Osteoprotegerin

    Scientists showed by microCT that mice with p53 deletion systemically or specifically in mesenchymal cells possess significantly higher bone density than their respective littermate controls.
    [Cell Death & Differentiation]

    Full Article

    Inhibition of Circulating miR-194-5p Reverses Osteoporosis through Wnt5a/β-Catenin Signaling-Dependent Induction of Osteogenic Differentiation

    Investigators found that aberrant expression of LCP1 could induce the proliferation and metastasis of osteosarcoma cells in vitro and in vivo by destabilizing neuregulin receptor degradation protein-1 and subsequently activating the JAK2/STAT3 signaling pathway.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    REVIEWS

    Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential

    Scientists review the immunomodulatory aspects of naïve and engineered MSCs, and discuss strategies for increasing the potential of successfully using MSCs in clinical settings.
    [Trends in Pharmacological Sciences]

    Abstract

    Shattering Barriers Toward Clinically Meaningful MSC Therapies

    The authors discuss the major clinical challenges with MSC therapies, the details of these challenges, and the potential bioengineering approaches that leverage the unique biology of MSCs to achieve more potent and versatile therapies.
    [Science Advances]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Advisory Committee Sets Review Date for Mesoblast’s Remestemcel-L in Pediatric Steroid-Refractory Acute Graft versus Host Disease

    Mesoblast Limited announced that the Oncologic Drugs Advisory Committee of the United States Food and Drug Administration has scheduled a meeting on August 13, 2020 to review data supporting the Company’s Biologics License Application for approval of RYONCIL™ for the treatment of steroid-refractory acute graft versus host disease in children.
    [Mesoblast Ltd]

    Press Release

    French Science Bill Promises Boost to Public R&D

    The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Editorial

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    JOB OPPORTUNITIES

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    KU Leuven – Leuven, Belgium

    Postdoctoral Position – Bone and Stem Cell Research

    University of Connecticut Health – Farmington, Connecticut, United States

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    Helmholtz Zentrum München – Neuherberg, Germany

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