 | | Vol. 12.31 – 11 August, 2020 |
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| Scientists review current and potential future approaches for the development of sarcoma therapies based on this emerging understanding of chromatin dysregulation.
[Nature Reviews Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A biphasic gelatin solution/hydrogel system was used for 3D culture of human bone marrow–derived mesenchymal stem cells to investigate the influence of gelatin solution viscosity on simultaneous osteogenic and adipogenic differentiation at the same culture condition.
[Advanced Healthcare Materials] |
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| The authors explored the role of bone mesenchymal stem cells‐derived and siRNAs‐encapsulated exosomes in osteonecrosis of the femoral head.
[Journal of Cellular and Molecular Medicine] |
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| Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine] |
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| Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology] |
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| Using a colocalization analysis approach on ToF-SIMS images of protein-coated microparticles, the authors showed that the use of propyleneglycol over PVA as well as the substitution of poly (lactic-co-glycolic acid) by the triblock copolymer resulted in enhanced protein adsorption.
[Biointerphases] |
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| | Scientists report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly reduced osteoarthritis (OA) cartilage damage in a murine model of obesity-induced OA.
[Scientific Reports] |
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| Researchers evaluated the efficacy of a combined triple interpenetrating network hydrogel and mesenchymal stem cell therapy targeting moderate-severity disc degeneration in a clinically relevant goat model.
[Tissue Engineering] |
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| The authors assessed the bone regeneration properties of a composite 3D honeycomb structure from the electrostatic template assisted deposition process by an alternate deposition of electrospun polycaprolactone nanofibers and electrosprayed hydroxyapatite nanoparticles on a honeycomb micropatterned substrate.
[Journal of Tissue Engineering and Regenerative Medicine] |
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| Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
[Stem Cells] |
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| Tyme Technologies, Inc. announced a positive outcome of an interim futility review for the HopES Sarcoma Phase II clinical trial that is evaluating TYME’s lead cancer metabolism-based candidate, SM-88, as a potential oral treatment for patients with Ewing’s Sarcoma and other high-risk sarcomas.
[Tyme Technologies, Inc. (BusinessWire, Inc.)] |
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| Calidi Biotherapeutics, Inc., announced that the Investigational New Drug application submitted by its partner, Personalized Stem Cells, Inc. has received FDA approval for the treatment of COVID-19 and pneumonia patients using stem cell therapy.
[Calidi Biotherapeutics, Inc.] |
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| August 27 – August 29
Virtual |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Nanyang Technological University – Singapore, Singapore |
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| | University of Connecticut Health – Farmington, Connecticut, United States |
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| | Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany |
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| | Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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