Mesenchymal Cell News Volume 12.33 | Aug 25 2020

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    MESCN 12. 33 | 25 Aug 2020


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.33 – 25 August, 2020
    TOP STORY

    ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation

    Motivated by the enormous advantages of Zn‐based metal-organic framework‐derived nanocarbons, C‐ZnO nanocarbons‐modified fibrous scaffolds for stem cell‐based osteogenic differentiation were constructed.
    [Small]

    Full Article

    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal
    IN VITRO

    CircRNA-vgll3 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells via Modulating miRNA-Dependent Integrin α5 Expression

    Scientists showed that circRNA-vgll3 originating from the vgll3 locus markedly enhanced osteogenic differentiation of adipose-derived mesenchymal stem cells.
    [Cell Death & Differentiation]

    Full Article

    MicroRNA-377-3p Released by Mesenchymal Stem Cell Exosomes Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Targeting RPTOR to Induce Autophagy

    Investigators found lipopolysaccharide significantly increased inflammatory factors, administration of exosomes released by human umbilical cord MSCs successfully improved lung morphometry.
    [Cell Death & Disease]

    Full Article

    Monitoring Membrane Viscosity in Differentiating Stem Cells using BODIPY-Based Molecular Rotors and FLIM

    Researchers demonstrated that differentiation of MSCs resulted in distinct membrane viscosities, that reflected the change in lipidome of the cells following differentiation.
    [Scientific Reports]

    Full Article

    Effects of Bone Marrow Mesenchymal Stem Cells on Ovarian and Testicular Function in Aging Sprague-Dawley Rats Induced by D-Galactose

    Adherent culture was used to isolate and purify rat MSCs. The status, proliferation and differentiation of MSCs were detected by hematoxylin-eosin staining, MTT, colony formation, flow cytometry and directional differentiation.
    [Cell Cycle]

    Abstract

    IN VIVO

    WTAP Promotes Osteosarcoma Tumorigenesis by Repressing HMBOX1 Expression in an m6A-Dependent Manner

    WTAP was found to be highly expressed in osteosarcoma tissue and it was an independent prognostic factor for overall survival in osteosarcoma.
    [Cell Death & Disease]

    Full Article

    The Vascular Nature of Lung-Resident Mesenchymal Stem Cells

    The authors investigated the vascular nature of lung-resident mesenchymal stem cells using healthy human lung tissue.
    [Stem Cells Translational Medicine]

    Full Article

    Pancreas-Derived Mesenchymal Stromal Cells Share Immune Response-Modulating and Angiogenic Potential with Bone Marrow Mesenchymal Stromal Cells and Can Be Grown to Therapeutic Scale under Good Manufacturing Practice Conditions

    MSC isolates were derived from low-purity islet fractions and expanded in platelet lysate-supplemented medium or in commercially available xenogeneic-free medium.
    [Cytotherapy]

    Full Article

    Culture mesenchymal stem cells, exosome-free
    REVIEWS

    Coronavirus Disease 2019: A Tissue Engineering and Regenerative Medicine Perspective

    Researchers review the recent clinical trials and the therapeutic benefits of MSCs in coronavirus‐induced acute respiratory distress syndrome.
    [Stem Cells Translational Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    NantKwest and ImmunityBio Sign Collaboration Agreement for Joint Development, Manufacturing, Marketing, and Commercialization of COVID-19 Vaccine and Related Therapeutics

    NantKwest, Inc. announced the signing of a definitive agreement to jointly develop, manufacture, market, and commercialize therapeutics and vaccines for combating the COVID-19 pandemic. The two product candidates currently in development under the agreement are a mesenchymal stem cell therapeutic from NantKwest, whose goal is to reduce the time a critically ill patient spends on a ventilator; and a COVID-19 vaccine product from ImmunityBio, which is anticipated to soon enter into a Phase I clinical trial.
    [NantKwest, Inc. ]

    Press Release

    FEATURED EVENT

    Till & McCulloch Meetings 2020

    October 26 – 28
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Postdoctoral Research Associate – Translational Cancer

    University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States

    Postdoctoral Position – Bone and Stem Cell Research

    University of Connecticut Health – Farmington, Connecticut, United States

    Junior Research Group Leader Position – Stem Cell Experimental Oncology

    Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany

    > See All Jobs

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