Mesenchymal Cell News Volume 12.35 | Sep 8 2020

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    MESCN 12.35 | 8 Sep 2020


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.35 – 8 September, 2020
    TOP STORY

    BMP-Induced
    Atoh8 Attenuates Osteoclastogenesis by Suppressing Runx2 Transcriptional Activity and Reducing the Rankl/Opg Expression Ratio in Osteoblasts

    Scientists identified atonal homolog 8, which was directly upregulated by the bone morphogenetic protein-Smad1 axis in osteoblasts.
    [Bone Research]

    Full Article

    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    PUBLICATIONSRanked by the impact factor of the journal
    IN VITRO

    Impact of Sustained Transforming Growth Factor-β Receptor Inhibition on Chromatin Accessibility and Gene Expression in Cultured Human Endometrial MSC

    Researchers combined RNA-seq and ATAC-seq to study the impact of sustained transforming growth factor-β receptor inhibition on gene expression and chromatin architecture of endometrial mesenchymal stem cells.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    MicroRNA-3148
    Acts As Molecular Switch Promoting Malignant Transformation and Adipocytic Differentiation of Immortalized Human Bone Marrow Stromal Cells via Direct Targeting of the SMAD2/TGFβ Pathway

    Scientists investigated the role of miR-3148 in regulating human stromal mesenchymal stem cell differentiation and transformation.
    [Cell Death Discovery]

    Full Article

    The
    Effects of Shock Wave Stimulation of Mesenchymal Stem Cells on Proliferation, Migration, and Differentiation in an Injectable Gelatin Matrix for Osteogenic Regeneration

    Scientists focused on investigating extracorporeal shock waves for their effects on proliferation, migration, and osteogenic differentiation in an injectable gelatin matrix capable of undergoing covalent cross‐linking in vivo.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    A
    Highly Efficient Non-Viral Process for Programming Mesenchymal Stem Cells for Gene Directed Enzyme Prodrug Cancer Therapy

    The authors showed the high transfection efficiency of human adipose tissue derived-MSCs using a cost-effective and off-the-shelf Polyethylenimine, in the presence of histone deacetylase 6 inhibitor and fusogenic lipids.
    [Scientific Reports]

    Full Article

    IN VIVO

    RNF40
    Exerts Stage-Dependent Functions in Differentiating Osteoblasts and Is Essential for Bone Cell Crosstalk

    Researchers demonstrated that RNF40 has a stage-dependent function in controlling osteoblast differentiation in vivo.
    [Cell Death & Differentiation]

    Abstract

    Broadening
    the Spectrum of NTRK Rearranged Mesenchymal Tumors and Usefulness of Pan-TRK Immunohistochemistry for Identification of NTRK Fusions

    To gain further insights into the staining profile with the pan-TRK assay, scientists analyzed a large number of soft tissue sarcomas and correlated their findings with molecular testing.
    [Modern Pathology]

    Full Article

    Mesenchymal
    Stem Cells Derived Extracellular Vesicles Improve Behavioral and Biochemical Deficits in a Phencyclidine Model of Schizophrenia

    Researchers assessed the feasibility of intranasal delivery of mesenchymal stem cell-derived-extracellular vesicles to alleviate schizophrenia-like behaviors in a phencylidine model of schizophrenia.
    [Translational Psychiatry]

    Full Article

    Comparative
    Proteomic Analysis of Osteogenic Differentiated Human Adipose Tissue and Bone Marrow-Derived Stromal Cells

    Human adipose-derived stromal cells and bone marrow-derived stromal cells were characterized by FACS analysis and tri-lineage differentiation, followed by an intraindividual comparative proteomic analysis upon osteogenic differentiation.
    [Journal of Cellular and Molecular Medicine]

    Full Article

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    REVIEWS

    Mechanisms of Bone Development and Repair

    The isolation of a single skeletal stem cell population through cell surface markers and the development of single-cell technologies are enabling precise elucidation of cellular activity and fate during bone repair by providing key insights into the mechanisms that maintain and regenerate bone during homeostasis and repair.
    [Nature Reviews Molecular Cell Biology]

    Abstract

    Effects
    of Biophysical Cues of 3D Hydrogels on Mesenchymal Stem Cells Differentiation

    The authors summarize the effects of biophysical cues on MSCs differentiation in 3D hydrogels and underlying mechanobiology to update the understanding of stem cell biology and guide tissue engineering.
    [Journal of Cellular Physiology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Cymerus
    MSCs Demonstrate Efficacy in Preclinical Lung Disease Study

    Cynata Therapeutics Limited announced positive efficacy data from a study of its induced pluripotent stem cell-derived Cymerus mesenchymal stem cells in a preclinical rodent model of idiopathic pulmonary fibrosis.
    [Cynata Therapeutics Limited (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    8th
    International Conference on Stem Cell Engineering 2021

    July 8 – July 10, 2021
    Boston, Massachusetts, United States


    > See All Events

    JOB OPPORTUNITIES


    Research Positions – Tissue Engineering

    Terasaki Research Institute – Los Angeles, California, United States

    Postdoctoral Position – Cancer Biology and Cancer Microenvironments

    University of Copenhagen – Copenhagen, Denmark

    Research Fellow – Bone Tissue Engineering

    University of Michigan – Ann Arbor, Michigan, United States


    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Postdoctoral
    Positions – Signal Transduction

    NYU Langone Health – New York, New York, United States


    Postdoctoral Research Associate – Translational Cancer

    University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States

    > See All Jobs

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