 | | Vol. 12.36 – 15 September, 2020 |
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| Researchers assessed the safety and tolerability of CYP-001 (iPSC-derived MSCs), while the secondary objectives were to evaluate efficacy based on the proportion of participants who showed a complete response , overall response and overall survival by days 28/100.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists characterized cell lines derived from human endometrial epithelial cells and mesenchymal cells from patients with and without endometriosis.
[F&S Science] |
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| Investigators discovered an alternative “migration-by-tethering” mechanism through which cancer cells gained momentum to migrate by adhering to mesenchymal stem cells or osteoblasts.
[npj Breast Cancer] |
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| Researchers interrogated compressive force-elicited transcriptomic changes in mesenchymal stem cells purified from human periodontal ligament, and identified H3K27me3 and E2F signatures populated within upregulated and weakly downregulated genes.
[Cell Death & Disease] |
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| CD73-positive population from various tissues existed individually in flowcytometric pattern, especially subcutaneous fat- and amniotic-derived cells showed the highest enrichment of CD73-positive cells.
[Scientific Reports] |
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| For the fabrication of spheroids containing endothelial tubular structures, MSCs and endothelial cells are co‐cultured with MicoCell.
[Advanced Biosystems] |
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| With the capability of directly responding to the acidic microenvironment at focal areas followed by triggered release of the IL-4 plasmid-loaded liposomes within a few hours to suppress the release of inflammatory cytokines and promote neural differentiation of mesenchymal stem cells in vitro, the microenvironment-responsive immunoregulatory electrospun fibers were implanted into acute spinal cord injury rats.
[Nature Communications] |
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| Researchers evaluated the consequences of cardiac mesenchymal cell administration on post myocardial infarction immune responses in vivo and paracrine-mediated immune cell function in vitro.
[Scientific Reports] |
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| The authors highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer.
[Science Signaling] |
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| Researchers highlight considerations, including whether the source of mesenchymal stem cell (MSC) isolation impacts the efficacy and safety of the therapy, in addition to assessing the feasibility of MSC topical application to the cornea and ocular surface through analysis of potential scaffolds and cell carriers for application to the eye.
[Stem Cells Translational Medicine] |
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| Cynata Therapeutics Limited announced positive efficacy data from a study of its iPSC-derived Cymerus™ mesenchymal stem cells (MSCs) in a preclinical rodent model of idiopathic pulmonary fibrosis.
[Cynata Therapeutics Limited (GlobeNewswire, Inc.)] |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | NYU Langone Health – New York, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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