 | | | Vol. 12.37 – 22 September, 2020 |
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| In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease] |
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| The authors performed in vitro and in vivo studies to elucidate the mechanisms responsible for the change in the immunophenotype of MSCs from immunoprivileged to immunogenic under ischemic conditions.
[FASEB Journal] |
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| Investigators attempted to enlarge the application range of mesenchymal stem cells with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes.
[International Journal of Oral Science] |
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| The influence of parylene N film on the spheroid formation of osteoblast-like cells was determined and compared with that of high-hydrophilicity microenvironments. The formation of spheroids and regulation of differentiation in human mesenchymal stem cells on parylene N film was demonstrated.
[Scientific Reports] |
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| The synthesized polycaprolactone/metal ion-wollastonite scaffold was biocompatible to mouse mesenchymal stem cells and enhanced the mRNA expression of osteoblastic specific marker genes including alkaline phosphatase and type I collagen and major transcription factor Runx2 in the presence of osteogenic medium indicates the osteoconductive nature of the scaffolds.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| Based on the anti‐inflammatory effects of alpha‐1 antitrypsin (AAT), scientists generated human AAT engineered MSCs by infecting human bone marrow‐derived MSCs with the pHAGE CMV‐a1aT‐UBC‐GFP‐W lentiviral vector.
[Stem Cells Translational Medicine] |
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| Researchers evaluated the consequences of cardiac mesenchymal cell administration on post myocardial infarction immune responses in vivo and paracrine-mediated immune cell function in vitro.
[Scientific Reports] |
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| Extracellular vesicles were isolated from transfected or untransfected mesenchymal stem cells, and were used to treat lung cancer with/without inhibitor, mimic, overexpression plasmid or shRNAs. CCK-8 assay, colony formation, transwell assay and flow cytometry were carried out to determine biological functioning of lung cancer cells.
[Molecular Therapy-Oncolytics] |
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| The use of mesenchymal stromal cells for COVID-19 has become an attractive avenue down which almost 70 different clinical trial teams have ventured.
[Journal of Translational Medicine] |
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| The authors give an overview the involvement of TSP family members in the bone tissue microenvironment, focusing on their activity on osteoclasts and osteoblasts in bone remodeling, and present the evidence to date of their roles in bone metastasis establishment and growth.
[American Journal of Physiology-Cell Physiology] |
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| Brainstorm Cell Therapeutics Inc. announced that the Japanese Patent Office has granted Brainstorm’s Japanese Patent, number: 6,753,887, titled: ‘Methods of Generating Mesenchymal Stem Cells which Secrete Neurotrophic Factors’.
[Brainstorm Cell Therapeutics Inc.] |
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| The Medical Research Council (MRC) and the Japan Agency for Medical Research and Development (AMED) have joined forces to support eight new Regenerative Medicine research partnerships. In this landmark collaboration, MRC and AMED will make a total of almost £7 million available to support collaborative projects that seek to advance regenerative approaches towards clinical use.
[Medical Research Council] |
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| October 13 – October 14
Virtual |
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| | Zhejiang University – Zhejiang, China |
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| | NYU Langone Health – New York, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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