Mesenchymal Cell News Volume 12.38 | Sep 29 2020

May 12, 2022

2020-29-09 | MESCN 12.38

Mesenchymal Cell News by STEMCELL Technologies

Vol. 12.38 – 29 September, 2020

TOP STORY

Bone
Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Investigators studied the contribution of nestin⁺ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
[Cell Metabolism]

Full Article Graphical Abstract

Culture mesenchymal stem cells, exosome-free

PUBLICATIONSRanked by the impact factor of the journal

IN VITRO

Raman-Guided Subcellular Pharmaco-Metabolomics for Metastatic Melanoma Cells

Scientists utilized Raman spectro-microscopy for spatial mapping of metabolites within single cells, with the specific goal of identifying druggable metabolic susceptibilities from a series of patient-derived melanoma cell lines.
[Nature Communications]

Full Article

Nanoparticle Enhanced Combination Therapy for Stem-Like Progenitors Defined by Single-Cell Transcriptomics in Chemotherapy-Resistant Osteosarcoma

The authors used single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.
[Signal Transduction and Targeted Therapy]

Full Article

Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-193a Reduces Cisplatin Resistance of Non-Small Cell Lung Cancer Cells via Targeting LRRC1

A549 and H1299 cell lines were screened out and their parent cells and drug-resistant cells were co-cultured with human bone marrow mesenchymal stem cells-derived exosomes that had been transfected with miR-193a mimic or si-LRRC1 to detect the colony formation, migration, apoptosis, invasion and proliferation of non-small cell lung cancer cells.
[Cell Death & Disease]

Full Article

A Novel lncRNA LNC_000052 Leads to the Dysfunction of Osteoporotic BMSCs via the miR-96-5p–PIK3R1 Axis

Researchers found that both LNC_000052 and PIK3R1 shared a miRNA target, miR-96-5p, which was downregulated in osteoporotic bone-marrow derived MSCs.
[Cell Death & Disease]

Full Article

SERRS Multiplexing with Multivalent Nanostructures for the Identification and Enumeration of Epithelial and Mesenchymal Cells

Investigators present a new protocol based on surface enhanced resonance Raman scattering (SERRS) gold multivalent nanostructures to identify and enumerate tumor cells with epithelial and mesenchymal markers.
[Scientific Reports]

Full Article

Osteogenic Differentiation Potential of Porcine Bone Marrow Mesenchymal Stem Cell Subpopulations Selected in Different Basal Media

Scientists evaluated the effects of αMEM, aDMEM, M199, αMEM/M199, aDMEM/M199 and αMEM/aDMEM mediaon porcine bone marrow MSC derivation, expression of number of osteogenic markers at fifth and tenth passage in multipotentporcine (p)MSCs before differentiation, and differentiation of pMSC to osteogenic lineage.
[Biology Open]

Abstract Full Article

IN VIVO

STAT3–BDNF–TrkB Signaling Promotes Alveolar Epithelial Regeneration after Lung Injury

Loss or blockade of AT2-specific Stat3, Bdnf or mesenchyme-specific TrkB compromised repair and reduced Fgf7 expression by niche cells. A TrkB agonist improved outcomes in vivo following lung injury.
[Nature Cell Biology]

Full Article

Dental
Cell Type Atlas Reveals Stem and Differentiated Cell Types in Mouse and Human Teeth

Scientists report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggested a coherent model of cell dynamics enabling unarrested growth.
[Nature Communications]

Full Article Press Release

Mesenchymal
Stem Cell Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via miR-31-5p/ATF6 axis

Researchers investigated the role of MSC-exosomes on endplate chondrocytes with a tert-butyl hydroperoxide-induced oxidative stress cell model and an intervertebral disc degeneration rat model.
[Molecular Therapy-Nucleic Acids]

Abstract Graphical Abstract

Myh11⁺
Microvascular Mural Cells and Derived Mesenchymal Stem Cells Promote Retinal Fibrosis

Using lineage tracing technology, the authors demonstrated that after chemical ocular injury, Myh11⁺ mural cells detached from the retinal microvasculature and differentiated into myofibroblasts to form an epiretinal membrane.
[Scientific Reports]

Full Article

https://www.stemcell.com/mesenchymal-stromal-cells-updates-and-debates?utm_source=scpodcast&utm_medium=podcast&utm_campaign=msc_topicclusterf20

REVIEWS

Stem/Progenitor
Cell-Based Transplantation for Retinal Degeneration: A Review of Clinical Trials

Scientists provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease]

Full Article

Differentiation
of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

The authors summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]

Full Article Graphical Abstract

INDUSTRY AND POLICY NEWS

Orgenesis
Announces Agreement to Acquire Koligo Therapeutics, a Leader in Personalized Cell Therapies

Orgenesis Inc. and Koligo Therapeutics, Inc. have announced that the two companies have entered into a definitive merger agreement. Koligo’s lead clinical development program is for KT-PC-301, an autologous cell therapy containing a population of mesenchymal stem cells, vascular endothelial cells, and immune cells, under investigation for the treatment of COVID-19-related Acute Respiratory Disease Syndrome.
[Orgenesis Inc.]

Press Release

FEATURED EVENT

Bone
Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Raman-Guided Subcellular Pharmaco-Metabolomics for Metastatic Melanoma Cells

Nanoparticle Enhanced Combination Therapy for Stem-Like Progenitors Defined by Single-Cell Transcriptomics in Chemotherapy-Resistant Osteosarcoma

Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-193a Reduces Cisplatin Resistance of Non-Small Cell Lung Cancer Cells via Targeting LRRC1

A Novel lncRNA LNC_000052 Leads to the Dysfunction of Osteoporotic BMSCs via the miR-96-5p–PIK3R1 Axis

SERRS Multiplexing with Multivalent Nanostructures for the Identification and Enumeration of Epithelial and Mesenchymal Cells

Osteogenic Differentiation Potential of Porcine Bone Marrow Mesenchymal Stem Cell Subpopulations Selected in Different Basal Media

STAT3–BDNF–TrkB Signaling Promotes Alveolar Epithelial Regeneration after Lung Injury

Dental
Cell Type Atlas Reveals Stem and Differentiated Cell Types in Mouse and Human Teeth

Mesenchymal
Stem Cell Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via miR-31-5p/ATF6 axis

Myh11⁺
Microvascular Mural Cells and Derived Mesenchymal Stem Cells Promote Retinal Fibrosis

Stem/Progenitor
Cell-Based Transplantation for Retinal Degeneration: A Review of Clinical Trials

Differentiation
of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

Orgenesis
Announces Agreement to Acquire Koligo Therapeutics, a Leader in Personalized Cell Therapies

i-Vaccines 2021: International Vaccines & Virology Conference

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Postdoctoral Researcher – Regenerative Medicine (Stem Cell Extracellular Vesicles)

Postdoctoral Researcher – Stem Cells & Aging

Research Fellow – Bone Tissue Engineering

Research Scientist – Tissue Engineering

Research Positions – Tissue Engineering

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