 | | Vol. 12.40 – 13 October, 2020 |
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Scientists showed that Gli1+ MSCs, previously shown to contribute to myofibroblasts during scarring, promoted metaplastic differentiation of airway progenitors into KRT5+ basal cells.
[Nature Cell Biology] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Investigators identified a constitutive mechanism of resistance to PARP inhibitor (PARPi). They report that the bone marrow microenvironment facilitates DNA double-strand break repair activity in leukemia cells to protect them against PARPi-mediated synthetic lethality.
[Cell Reports] |
| | Researchers investigated the effect of Tankyrase inhibition in osteoblast differentiation of human skeletal MSCs. A Tankyrase inhibitor, XAV-939, was identified during a functional library screening of small molecules.
[Scientific Reports] |
| | WJ-MSCs were encapsulated in 3D hydrogels derived from human fibrin or platelet lysate and the oxygen level was adjusted to physiological normoxia (5% O2).
[Scientific Reports] |
| | The effects of miR‐140‐5p on tissue‐to‐bone healing was investigated. Clone formation experiment, flow cytometry, Alizarin Red S Staining and Oil Red O Staining were performed to investigate the biological characteristics of mouse embryonic bone marrow MSCs C3H10T1/2.
[Cell Biochemistry and Function] |
| | Investigators exploited the DMP1 promoter as a predictive marker of MSC differentiation towards osteoblasts. Using CRISPR/Cas9 technology, they identified a distinctive change in fluorescence intensities of GFP knock‐in and osteoblast differentiation.
[Journal of Gene Medicine] |
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| The authors report that deleting Pinch1 in limb MSCs and Pinch2 globally (double knockout) in mice caused severe chondrodysplasia, while single mutant mice did not display marked defects.
[Bone Research] |
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| Single-cell mRNA-sequencing analysis of the highly metabolically (hm) active cells from metastatic prostate cancer patients revealed that approximately 10% were canonical EpCAM+ hm-circulating tumor cells (CTCs), 3% were EpCAM– hm-CTCs with upregulation of prostate-related genes, and 87% were hm-circulating stromal cells with profiles characteristic for cancer-associated fibroblasts, MSCs, and endothelial cells.
[Science Advances] |
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| Zfp423, encoding a Kruppel-type zinc finger transcription factor essential for cerebellar development and mutated in rare cases of cerebellar vermis hypoplasia/Joubert syndrome and other ciliopathies, is expressed in the hindbrain roof plate, from which the IV ventricle choroid plexus arises, and, later, in MSCs giving rise to the stroma and leptomeninges.
[Development] |
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| The authors give a brief description of MSCs, their sources and markers, and the different attempts that have been made towards achieving the goal of differentiating MSCs into neurons.
[Journal of Molecular Neuroscience] |
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| Sorrento Therapeutics, Inc. entered into an exclusive license agreement with Personalized Stem Cells, Inc. to acquire global rights to its adipose-derived MSCs for patients suffering from acute respiratory distress syndrome associated with COVID-19, which have been cleared for a Phase I clinical trial by the FDA.
[Sorrento Therapeutics, Inc.] |
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| November 11 – November 13
Virtual |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | Zhejiang University – Zhejiang, China |
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