 | | Vol. 12.43 – 3 November, 2020 |
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| Nanoengineered MSCs were developed as a supersonosensitizer, named M/LPV/O2, for improving nondestructive sonodynamic therapy against oral squamous cell carcinoma along with good therapeutic compliance.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| When adenoviral-Mohawk-transduced MSCs were seeded on TGF-β3-conjugated decellularized meniscus scaffold (DMS) and inserted into experimental tears in meniscus explants, they increased glycosaminoglycan content, extracellular matrix interconnectivity, cell infiltration into the DMS, and improved biomechanical properties.
[Science Translational Medicine] |
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| The IL1β-induced inflammatory secretome of IL1RAP-expressing acute myeloid leukemia (AML) cells grown on a stromal layer of MSCs affected normal hematopoiesis including hematopoietic stem/progenitor cells while AML cell proliferation was not affected.
[Haematologica] |
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| Scientists report that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein family of cytokines, maintains Ewing sarcoma growth by preventing Src hyperactivation.
[Cell Reports] |
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| Bladder cancer cells were co-cultured with exosomes isolated from human umbilical cord MSCs over-expressing miR-139-5p. The intercellular transfer of miR-139-5p along with in vitro and in vivo functions was determined using gain- and loss-of-function approaches.
[Oncogene] |
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| The authors determined intramedullary silver release profiles in vivo, which were used to test relevant Ag+ concentrations on MSC function in vitro.
[Scientific Reports] |
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| Researchers implicated perivascular MSCs as important regulators of chronic adipose-tissue inflammation in obesity and identify zinc-finger protein 423 as a transcriptional break on NF-κB signaling.
[Nature Metabolism] |
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| Scientists showed that bone marrow stem cell-derived exosomes after strontium-substituted calcium silicate stimulation could significantly promote in vitro angiogenesis of human umbilical vein endothelial cells, which might be attributed to elevated pro-angiogenic miR-146a cargos and inhibition of Smad4 and NF2 proteins.
[Acta Biomaterialia] |
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| The authors indicated that intravenous injection of allogenic umbilical cord-MSCs without immunosuppression exert beneficial effects in subacute spinal cord injury (SCI) and thus could be a useful therapy to improve the functional capacity among patients with SCI.
[Spinal Cord] |
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| Investigators review recent progress in our understanding of sensory nerves biology in the stem cell niche.
[Stem Cells Translational Medicine] |
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| Stem cells can be induced to differentiate to corneal epithelial cells and used in treatment in corneal epithelium deficiency. Multipotent stem cells (MSCs) and pluripotent stem cells (ESCs and iPSCs) are promising cells to address the problem.
[International Journal of Molecular Sciences] |
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| The authors highlight the sources of variability in studies using MSCs in Parkinson’s disease therapy, including MSC sources, the use of autologous or allogenic MSCs, dose, delivery methods, patient factors, and measures of clinical outcome.
[NPJ Regenerative Medicine] |
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| Some clinical trials have confirmed the effectiveness of MSC therapy for liver disease, but its application has not been promoted and approved. There are still many issues that should be solved prior to using MSC therapy in clinical applications.
[Cell and Bioscience] |
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| AgeX Therapeutics, Inc. and ImStem Biotechnology, Inc. announced that ImStem has obtained from AgeX a non-exclusive, royalty-bearing sublicense to use AgeX’s clinical-grade embryonic stem cell line ESI-053 to derive ImStem’s investigational MSC product candidate IMS001 for development in COVID-19 as well as acute respiratory distress syndrome from other causes.
[AgeX Therapeutics, Inc.] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | University of Chicago – Chicago, Illinois, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | Zhejiang University – Zhejiang, China |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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Cancer Stem Cell News
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