 | | Vol. 12.44 – 10 November, 2020 |
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| Alpha-ketoglutarate ameliorated the senescence-associated phenotypes of bone marrow MSCs derived from aged mice, as well as promoting their proliferation, colony formation, migration, and osteogenic potential.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using human cord tissue‐derived MSCs (hCT‐MSCs), investigators demonstrated that hCT‐MSCs directly interacted with and reprogramed monocytes and macrophages.
[Stem Cells] |
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| Researchers defined the phenotypic response of human bone marrow-derived hMSCs to 2176 randomly generated surface topographies by probing basic functions such as migration, proliferation, protein synthesis, apoptosis, and differentiation using quantitative image analysis.
[Scientific Reports] |
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| Investigators revealed remarkable changes of multiple metabolites, especially lipids, in ovarian tissues after premature ovarian insufficiency (POI) generation. Following the transplantation of clinical-grade human umbilical cord MSCs, POI mice exhibited significant improvements in body weight, sex hormone levels, estrous cycles, and reproductive capacity.
[Stem Cell Research & Therapy] |
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| Scientists tested the suitability of MSC-sorting based on their FACS autofluorescence profile, for a rapid and non-invasive method of senescent cell elimination.
[Scientific Reports] |
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| Human Wharton’s Jelly-MSCs were grown on silk scaffolds and induced towards chondrogenesis by supplementation with L-ascorbic acid or platelet rich plasma.
[Scientific Reports] |
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| In vivo, PX-treatment caused substantial downregulation of IGF-1R, suppressing the growth of Ewing’s sarcoma xenografts. Functional studies reveal that PX exploits the antagonism between β-arrestin isoforms: in low ligand conditions, PX favored β-arrestin1/Mdm2-mediated ubiquitination/degradation of IGF-1R, a scenario usually exclusive to ligand abundancy, making PX more effective than antibody-mediated IGF-1R downregulation.
[Cancer Research] |
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| Scientists showed that microRNA-145 was associated with atherosclerosis by microRNA sequencing and bioinformatics analysis. MSC-derived miR-145 rich exosomes could efficiently deliver miR-145 from MSCs to human umbilical vein endothelial cells.
[Molecular Therapy-Nucleic Acids] |
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| A model of allergic rhinitis in BALB/c mice was established and evaluated to provide experimental subjects for further research. Preparation of human umbilical cord MSCs, including isolation, expansion culture, passaging, cryopreservation, and preparation of cell suspensions, provided materials for experimental research and clinical treatment.
[Scientific Reports] |
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| To develop an effective amyotrophic lateral sclerosis (ALS) treatment, investigators focused on MSCs expressing hepatocyte growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor using human artificial chromosome vector.
[iScience] |
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| The authors focus on the properties of MSC-derived extracellular vesicles and provide valuable insight regarding their beneficial therapeutic opportunities to further compare this alternative approach with conventional MSC therapy.
[Experimental and Molecular Pathology] |
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| MSCs are advantageous cells in regenerative medicine, exerting pleiotropic functions by producing soluble factors, such as exosomes. MSCs and their exosomes kinetic are affected by ageing and other aged exosomes.
[Cell Biochemistry and Function] |
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| IMAC Holdings, Inc. announced it is opening enrollment in its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic MSCs for the treatment of bradykinesia due to Parkinson’s disease.
[IMAC Holdings, Inc.] |
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| Jul 11 – 16, 2021
New London, New Hampshire, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, United States |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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