Mesenchymal Cell News Volume 12.46 | Nov 24 2020

    0
    37







    2020-24-11 | MESCN 12.46


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 12.46 – 24 November, 2020
    TOP STORY

    A Novel Negative Regulatory Mechanism of Smurf2 in BMP/Smad Signaling in Bone

    Smurf2 induced the ubiquitination of Smad1/5. Bone morphogenetic protein (BMP)/Smad signaling was enhanced in Smurf2−/− bone marrow stromal cells (BMSCs) stimulated with recombinant human BMP2, and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.
    [Bone Research]

    Full Article


    Explore virtual support and resources to stay productive and connected with your field.
    PUBLICATIONSRanked by the impact factor of the journal
    IN VITRO

    Enhanced
    Viability and Function of Mesenchymal Stromal Cell Spheroids Is Mediated via Autophagy Induction

    Scientists investigated the molecular mechanisms by which MSC3D gained the potential for enhanced cell viability. They found that macroautophagy/autophagy was highly induced and ROS production was suppressed in MSC3D as compared to 2D-cultured MSCs.
    [Autophagy]

    Abstract

    Articular
    Chondrocyte-Derived Extracellular Vesicles Promote Cartilage Differentiation of Human Umbilical Cord Mesenchymal Stem Cells by Activation of Autophagy

    Investigators successfully isolated chondrogenic-extracellular vesicles (C-EVs) from human multi-finger cartilage and found that C-EVs efficiently promoted the proliferation and chondrogenic differentiation of human umbilical cord MSCs, evidenced by highly expressed aggrecan, COL2A, and SOX-9.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical
    Abstract

    Syndecan-3 Regulates MSC Adhesion, ERK and AKT Signaling In Vitro
    and Its Deletion Enhances MSC Efficacy in a Model of Inflammatory Arthritis In Vivo

    MSCs isolated from bone marrow of wild type and Sdc3−/− mice were used to assess immunophenotype, differentiation, adhesion and migration properties and cell signaling pathways.
    [Scientific Reports]

    Full Article

    Cyclical Aggregation Extends In Vitro
    Expansion Potential of Human Mesenchymal Stem Cells

    Researchers assessed a novel cyclical aggregation as a means of expanding MSCs to maintain stem cell functionality. The cyclical aggregation consisted of an aggregation phase and an expansion phase by replating the dissociated MSC aggregates onto planar tissue culture surfaces.
    [Scientific Reports]

    Full Article

    IN VIVO

    Human
    Mesenchymal Stromal Cells Do Not Express ACE2 and TMPRSS2 and Are Not Permissive to SARS-CoV-2 Infection

    Scientists evaluated if human MSCs from both fetal and adult tissues constitutively expressed angiotensin‐converting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2) and, most importantly, if they could be infected by SARS‐CoV‐2.
    [Stem Cells Translational Medicine]

    Abstract

    Regeneration
    of a Full-Thickness Defect in Rotator Cuff Tendon with Umbilical Cord-Derived Mesenchymal Stem Cells in a Rat Model

    Researchers injected either umbilical cord MSCs or saline to the full-thickness rotator cuff defect and investigated macroscopic, histological and biomechanical results and cell trafficking.
    [PLoS One]

    Full Article

    Biomimetic
    Poly(γ-Glutamic Acid) Hydrogels Based on Iron (III) Ligand Coordination for Cartilage Tissue Engineering

    The authors confirmed that the mechanical properties of hydrogel enhanced by the introduction of metal ions Fe3+ could promote MSC proliferation, induce cartilage-specific gene expression, and increase secretion of hydroxyproline and glycosaminoglycan.
    [International Journal of Biological Macromolecules]

    AbstractGraphical Abstract

    Transcriptome
    Analysis of IPF Fibroblastic Foci Identifies Key Pathways Involved in Fibrogenesis

    Functional studies using CRISPR-Cas9 gene-edited cells demonstrated a key role for the TSC2/RHEB axis in regulating TGF-β1-induced mechanistic target of rapamycin complex 1 activation and collagen I deposition in mesenchymal cells reflecting idiopathic pulmonary fibrosis and other disease settings, including cancer-associated fibroblasts.
    [Thorax]

    Abstract

    Bone Marrow Tregs Mediate Stromal Cell Function and Support Hematopoiesis via Il-10

    Following Treg depletion, the function and phenotype of both MSCs and hematopoietic stem cells was impaired. Transplantation also revealed that a Treg-depleted niche had a reduced capacity to support hematopoiesis.
    [JCI Insight]

    Full Article


    Culture mesenchymal stem cells, exosome-free
    REVIEWS

    Current Trends on Applications of Stem Cells in Diabetic Nephropathy

    Scientists review the potential mechanism of stem cells as new therapeutic agents in the treatment of diabetic nephropathy (DN). They also review recent findings and updated information about not only the utilization of stem cells on DN in both preclinical and clinical trials but limitations and future expectations of stem cell-based therapy for DN.
    [Cell Death & Disease]

    Full Article

    Mesenchymal
    Stromal Cells for Acute Respiratory Distress Syndrome (ARDS), Sepsis and COVID 19 Infection: Optimizing the Therapeutic Potential

    The potential for MSC therapy in COVID-19 ARDS is discussed with insights from respiratory viral models and early clinical reports of MSC therapy in COVID-19.
    [Expert Review of Respiratory Medicine]

    Abstract

    INDUSTRY AND POLICY NEWS

    TRACON
    Pharmaceuticals Announces Submission for Approval Of Envafolimab (KN035) with the NMPA in China by its Corporate Partners Alphamab Oncology and 3D Medicines

    TRACON Pharmaceuticals, Inc. announced its corporate partners, Alphamab Oncology and 3D Medicines, have submitted a new drug application for the approval of envafolimab in the indication of MSI-H/dMMR cancer to the National Medical Products Administration (NMPA). Envafolimab, a subcutaneous PD-L1 single-domain antibody, is being developed in a registration trial for the treatment of sarcoma.
    [TRACON Pharmaceuticals, Inc.]

    Press Release

    Texas
    Heart to Participate in Global Stem Cell Study to Treat ARDS due to COVID-19

    The Texas Heart Institute has been selected as one of up to 60 sites in the world to participate in an international investigative study seeking to aid COVID-19 patients who develop acute respiratory distress syndrome (ARDS).
    [Texas Heart Institute]

    Press Release

    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021

    April 9 – April 14, 2021
    Washington, DC, United States


    > See All Events

    JOB OPPORTUNITIES

    Medical
    Director – Oncology Clinical Development (Cell and Gene Therapy)

    GSK – Waltham, Massachusetts; Collegeville, Pennsylvania, United States

    Postdoctoral Fellow – Damaged Tissue Restoration

    University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    Postdoctoral
    Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Positions – Stem Cells, Immunology, Biochemistry/Molecular Biology, Pathogenic Microbiology

    Zhejiang University-University of Edinburgh Institute – Haining, China

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Mesenchymal Cell News
    Archives Contact Us
    Mesenchymal Cell News Twitter