 | | Vol. 12.47 – 8 December, 2020 |
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| Researchers generated transcriptome (RNA-seq), epigenome (ChIP-seq of H3K27ac, H3K4me1, and H3K4me3 histone modifications), open chromatin (ATAC-seq), and chromatin interaction (promoter capture Hi-C) annotations of cultured primary decidua-derived MSCs and in vitro differentiated decidual stromal cells and developed a computational framework to integrate these functional annotations with results from a GWAS of gestational duration in 56,384 women.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors show that, in addition to cancer cell epithelial-to-mesenchymal transition, ovarian cancer cell metastasis relies on an epigenomic mesenchymal-to-epithelial transition in host MSCs. These reprogrammed MSCs, termed carcinoma-associated MSCs, acquired pro-tumorigenic functions and directly bind cancer cells to serve as a metastatic driver/chaperone.
[Cell Reports] |
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| Scientists identified the chemokines that were most upregulated during retinal degeneration and that could chemoattract MSCs.
[Molecular Therapy] |
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| Researchers characterized length scale dependent rheology in a well-established 3D cell culture platform for human (h)MSCs. hMSCs re-engineered their microenvironment through matrix metalloproteinase secretions and cytoskeletal tension.
[Acta Biomaterialia] |
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| Investigators examined the effects of varying exposure times and concentrations of tranexamic acid on proliferation rates, gene expression and differentiation capacity of chondrocytes and hMSCs, which underwent osteogenic differentiation.
[Journal of Clinical Medicine] |
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| The effect of the biophysical microenvironment on rat bone marrow MSC osteogenesis was studied both in vitro and in vivo.
[Stem Cell Research & Therapy] |
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| MSCs-extracellular vesicles treatment remarkably restored synaptic reorganization and up-regulated synaptic protein expression post-hypoxia-ischemic, concomitant with reducing osteopontin levels.
[Pharmacological Research] |
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| Scientists assessed the effects that menstrual blood-derived stromal cells had on the recruitment of macrophages and other innate immune cells in two mouse models of acute inflammation, a thioglycollate-elicited peritonitis model and a monobacterial sepsis model.
[Scientific Reports] |
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| MSC cultures were induced to differentiate toward adipocytes, where lipid droplets and adipocyte genes PPARγ2, ADIPO-Q, and FABP4 were observed in control non-polyp nasal mucosa-derived mesenchymal cells but were scarcely present in the cultures derived from the nasal polyps, where apoptosis was evident.
[International Journal of Molecular Sciences] |
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| Investigators determined the long-term safety and efficacy of repeated intrathecal administration of autologous MSC-derived neural progenitors in patients with progressive MS by evaluating subjects two years after treatment.
[Neurology: Neuroimmunology & Neuroinflammation] |
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| Investigators demonstrated that Forkhead box F1 (FOXF1) expression acted as a restraint on the migratory function of lung-resident-MSCs via its role as a novel transcriptional repressor of autocrine motility-stimulating factor Autotaxin.
[Scientific Reports] |
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| The authors present a proposed blueprint for translational regenerative medicine. They offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development.
[Science Translational Medicine] |
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| Rafael Pharmaceuticals, Inc. announced it will initiate a Phase II clinical trial of CPI-613® in combination with hydroxychloroquine in patients with clear cell sarcoma of soft tissue. In partnership with Sara’s Cure and Sarcoma Alliance for Research through Collaboration (SARC), they will begin enrolling patients into the Simon two-stage design trial at sites across the US.
[Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] |
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| February 25 – February 26, 2021
Virtual |
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| | National University of Ireland Galway – Galway, Ireland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| | Ncardia – Share Gosselies, Belgium |
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| | Stanford University – Stanford, California, United States |
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