 | | Vol. 12.49 – 15 December, 2020 |
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| MSCs were functionally reprogrammed in a stage-dependent manner with loss of their progenitor status and initiation of differentiation in the pre-fibrotic and acquisition of a pro-fibrotic and inflammatory phenotype in the fibrotic stage.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that compared with bone marrow-MSCs isolated from young and aged samples, NADH dehydrogenase iron-sulfur protein 6 (Ndufs6) was depressed in aged MSCs.
[Cell Death & Disease] |
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| The authors investigated the restorative effect of placenta derived (PD)-MSCs on injured ovaries in ovariectomized rats and the ability of intravenous transplantation of PD-MSCs to enhance ovarian vasculature and follicular development.
[Laboratory Investigation] |
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| Scientists assessed the feasibility of decellularizing rat dental pulp tissue and evaluated the ability of such scaffold to support stem cell repopulation.
[Scientific Reports] |
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| Researchers tested the ability of the stem cells derived from bone marrow, dental pulp and dental apical papilla to engineer pericyte-supported vascular capillaries when encapsulated along with human umbilical vein endothelial cells in gelatin methacrylate hydrogel.
[Scientific Reports] |
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| The authors characterized metabolic profiles of human (h)MSCs during expansion. They showed that alterations of cellular nicotinamide adenine dinucleotide (NAD+/NADH) redox balance and activity of the Sirtuin family enzymes regulated cellular senescence of hMSCs.
[Communications Biology] |
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| Researchers performed an unbiased interrogation of tumor MSCs, delineating the co-existence of distinct subsets of cancer-associated fibroblasts in the microenvironment of murine carcinomas, each endowed with unique phenotypic features and functions.
[Nature Communications] |
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| The transcriptomic properties, regulators and dynamics of osteosarcoma malignant cells together with their tumor microenvironment particularly stromal and immune cells were characterized.
[Nature Communications] |
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| c-FOS immunohistochemistry was negative in 45 cases of selected mesenchymal tumor types with epithelioid components that may histologically mimic proliferative fasciitis/proliferative myositis, including pleomorphic sarcoma with epithelioid features and epithelioid sarcoma.
[Modern Pathology] |
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| Investigators acquired a special kind of MSCs from the bone marrow of surgically resected tissue from the hand of a patient with polydactyly. Experiments were focused on the role of polydactyly bone marrow-derived MSCs in osteoarthritis.
[Cell Death Discovery] |
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| With improved control of epithelial, neuroglial, and mesenchymal cell fate specification, inner ear organoids would have the ability to truly recapitulate neurosensory function and dysfunction. Scientists discuss how single-cell atlases of the developing inner ear and technical innovations will be critical tools to advance inner ear organoid platforms.
[Cell Death & Differentiation] |
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| MSCs own self-renewal, differentiation, homing, immunomodulation and remain unaffected by the coronavirus on the virtue of the absence of ACE-2 receptors, indicating that MSCs could be used as an ameliorative approach for COVID-19.
[Life Sciences] |
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| Cynata Therapeutics Limited has announced a successful $15 million placement, led by a $10m investment from experienced healthcare investor BioScience Managers through the BioScience Managers Translation Fund I. This investment will allow Cynata to significantly expand its clinical development pipeline and scale their operations in Australia. Their Cymerusâ„¢ MSCs will be developed for three new, additional indications; idiopathic pulmonary fibrosis, renal transplantation and diabetic foot ulcers.
[Cynata Therapeutics Limited (GlobeNewswire, Inc.)] |
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| February 17 – 21, 2021
Virtual |
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| | Duke University – Durham, North Carolina, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| | Ncardia – Share Gosselies, Belgium |
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