 | | Vol. 13.00 – 5 January, 2021 |
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| The authors provided evidence that, upon their activation, platelets transfer respiratory-competent mitochondria to MSCs primarily via dynamin-dependent clathrin-mediated endocytosis.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers revealed that even under physiological conditions, MSCs produced and released a low level of tumor necrosis factor alpha (TNFα), unexpectedly required for preserving the self-renewal and differentiation of MSCs via autocrine/paracrine signaling.
[Bone Research] |
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| Scientists highlighted the dynamics of mesenchymal cells in the airway niche and implications for chronic airway-injury-associated diseases.
[Cell Reports] |
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| Investigators found that a single day of TGF-β1 exposure was sufficient to trigger bone marrow-derived MSC chondrogenic differentiation and tissue formation, similar to 21 days of TGF-β1 exposure.
[Communications Biology] |
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| Researchers report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralized the intermittent parathyroid hormone (PTH)-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.
[Signal Transduction and Targeted Therapy] |
| | Scientists found that Lgr5, a receptor for Rspo and a potent mediator of Wnt/β-catenin signaling, marks a subset of activated satellite cells that contribute to muscle regeneration.
[Cell Reports] |
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| The authors clarified whether long noncoding RNA Cancer-Associated Transcript-1 could regulate osteoblast proliferation and differentiation in ovariectomized rats with osteoporosis.
[Cancer Gene Therapy] |
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| Scientists found that Hsp90 inhibitors geldanamycin and its analog 17-DMAG increased degradation of the alveolar rhabdomyosarcoma driver oncoprotein PAX3-FOXO1 and induced the repressive epigenetic mark H3K9me3 and H3K36me3 at genomic loci of PAX3-FOXO1 targets.
[iScience] |
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| Researchers investigated the role of miR-199a-5p in T helper 17 (Th17) cell differentiation and determined whether extracellular vesicles derived from miR-199a-5p-modified adipose-derived MSCs could relieve immune thrombocytopenia by inhibiting Th17 differentiation.
[Laboratory Investigation] |
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| The authors outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy] |
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| Scientists discuss recent findings on the roles of cellular metabolism in determining skeletal stem cell fate, coordinating osteoblast and chondrocyte function, and organizing stromal support of hematopoiesis.
[Nature Metabolism] |
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| IMAC Holdings, Inc. has completed the first infusion of its investigational compound utilizing umbilical cord-derived allogenic MSCs in its Phase I clinical trial for the treatment of bradykinesia, or the gradual slowing and loss of spontaneous body movement, due to Parkinson’s disease.
[IMAC Holdings, Inc.] |
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| January 7 – 8, 2021
Virtual |
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| | University of Pennsylvania Perelman School of Medicine – Philadelphia, Pennsylvania, United States |
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| | Institute of Biomedicine, University of Gothenburg – Gothenburg, Sweden |
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| | Duke University – Durham, North Carolina, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Stanford University – Stanford, California, United States |
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