 | | Vol. 13.01 – 12 January, 2021 |
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| Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful MSC differentiation. Researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
[Cell Death & Disease] |
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| The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.
[Cell Death & Disease] |
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| Investigators suggested that YAP/TAZ pathway inhibition may prevent Ewing sarcoma (EwS) cell dissemination and metastasis, justifying further preclinical development of YAP/TAZ inhibitors for EwS treatment.
[Oncogenesis] |
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| To identify key drivers of metastasis, scientists studied human CCH-OS-D osteocarcinoma cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy] |
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| Using single-cell transcriptome profiling, the authors revealed a striking remodeling of the epithelial and mesenchymal niches with a decrease in functional populations that are linked to the aetiology of chronic inflammatory disease.
[eLife] |
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| Researchers determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine] |
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| Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
[Scientific Reports] |
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| Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite high-risk factors being identified, no test for early detection is available. Investigators identified circulating nucleic acid sequences associated with serum extracellular vesicle preparations at the time of OS diagnosis, as a step towards an OS early detection assay.
[Scientific Reports] |
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| Low-dose ultrashort wave was treated one day after spinal cord injury (SCI) and human umbilical cord MSC suspension was transferred to the lesion using a micro-syringe seven days after SCI.
[Life Sciences] |
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| The authors explore the current literature on adiponectin in bone, looking in depth at the comparison between human and murine data in health, with age and in disease.
[Bone Research] |
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| Bone Therapeutics announces it has treated the first patient for the ALLOB Phase IIb clinical study in patients with difficult-to-heal tibial fractures. The successful completion of Bone Therapeutics’ ALLOB trials would further demonstrate the promise of mesenchymal stromal derived cell therapies for the treatment of other underserved conditions.
[Bone Therapeutics] |
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| February 3 – 23, 2021
Virtual |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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| | University of Pennsylvania Perelman School of Medicine – Philadelphia, Pennsylvania, United States |
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| | Institute of Biomedicine, University of Gothenburg – Gothenburg, Sweden |
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