Mesenchymal Cell News Volume 13.02 | Jan 19 2021

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    2020-01-19 | MESCN 13.02


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.02 – 19 January, 2021
    TOP STORY

    Induction
    of Muscle-Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine

    Although the basal transcriptomes of adipocyte-derived induced multipotent stem cells and adipose tissue–derived MSCs were similar, changes were observed in histone modifications and CpG methylation at cis-regulatory regions consistent with an epigenetic landscape that was primed for tissue development and differentiation.
    [Science Advances]

    Full Article
    Culture mesenchymal stem cells, exosome-free
    PUBLICATIONSRanked by the impact factor of the journal
    IN VITRO

    Concomitant
    Control of Mechanical Properties and Degradation in Resorbable Elastomer-Like Materials Using Stereochemistry and Stoichiometry for Soft Tissue Engineering

    Researchers report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone.
    [Nature Communications]

    Full Article

    PI3K/Akt Pathway and Nanog Maintain Cancer Stem Cells in Sarcomas

    Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
    [Oncogenesis]

    Full Article

    Multi-Pronged
    Approach to Human Mesenchymal Stromal Cells Senescence Quantification with a Focus on Label-Free Methods

    Investigators grew human (h)MSC cultures over a period of seven months and compared early and senescent hMSC passages using the advanced flow cytometry and autofluorescence methods, which were benchmarked with the current standard in β-galactosidase staining.
    [Scientific Reports]

    Full Article

    Energy Metabolism During Osteogenic Differentiation: The Role of Akt

    Scientists tested the effect of osteogenic media containing ascorbate and β-glycerol phosphate, or various osteogenic hormones and growth factors on energy metabolism in long bone- and calvarial bone-derived osteoprogenitors.
    [Stem Cells and Development]

    Abstract

    IN VIVO

    Scaffold-Free
    Human Mesenchymal Stem Cell Construct Geometry Regulates Long Bone Regeneration

    The authors hypothesized that localized presentation of transforming growth factor (TGF)-β1 and bone morphogenetic protein-2 to engineered human MSC tubes mimicking femoral diaphyses induced endochondral ossification.
    [Communications Biology]

    Full Article

    Interferon-γ
    Enhances the Therapeutic Effect of Mesenchymal Stem Cells on Experimental Renal Fibrosis

    Scientists investigated whether pretreatment with IFN-γ could potentiate the anti-fibrotic ability of MSCs in rats with ischemia-reperfusion injury and unilateral ureter obstruction.
    [Scientific Reports]

    Full Article

    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Impact
    of 3D Cell Culture on Bone Regeneration Potential of Mesenchymal Stromal Cells

    The authors discuss current understanding of the effects of different 3D cell culture systems on proliferation, viability and osteogenic differentiation, as well as on the immunomodulatory and anti-inflammatory potential of MSCs.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bone Therapeutics and Rigenerand Sign Partnership for Cell Therapy Process Development

    Bone Therapeutics and Rigenerand SRL, the biotech company that both develops and manufactures medicinal products for cell therapy applications, primarily for regenerative medicine and oncology, announced the signing of a first agreement for a process development partnership.
    [Bone Therapeutics]

    Press Release

    FEATURED EVENT

    Hematopoietic
    Stem Cells: Biology, Disease, And Therapy

    March 9, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Position – Metabolism of Bone Marrow Adipocytes

    Institute of Pharmacology and Structural Biology – Toulouse, France

    Research Assistant – Cord Blood and Stem Cell Products

    University of Colorado – Aurora, Colorado, United States

    Professor or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    Scientific
    Communities & Communications Specialist

    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Senior
    Manager – FACS-Based Characterization

    Fondazione Human Technopole – Milan, Italy

    > See All Jobs

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