| Vol. 13.02 – 19 January, 2021 |
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| Although the basal transcriptomes of adipocyte-derived induced multipotent stem cells and adipose tissue–derived MSCs were similar, changes were observed in histone modifications and CpG methylation at cis-regulatory regions consistent with an epigenetic landscape that was primed for tissue development and differentiation. [Science Advances] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. [Nature Communications] |
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| Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells. [Oncogenesis] |
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| Investigators grew human (h)MSC cultures over a period of seven months and compared early and senescent hMSC passages using the advanced flow cytometry and autofluorescence methods, which were benchmarked with the current standard in β-galactosidase staining. [Scientific Reports] |
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| Scientists tested the effect of osteogenic media containing ascorbate and β-glycerol phosphate, or various osteogenic hormones and growth factors on energy metabolism in long bone- and calvarial bone-derived osteoprogenitors. [Stem Cells and Development] |
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| The authors hypothesized that localized presentation of transforming growth factor (TGF)-β1 and bone morphogenetic protein-2 to engineered human MSC tubes mimicking femoral diaphyses induced endochondral ossification. [Communications Biology] |
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| Scientists investigated whether pretreatment with IFN-γ could potentiate the anti-fibrotic ability of MSCs in rats with ischemia-reperfusion injury and unilateral ureter obstruction. [Scientific Reports] |
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| The authors discuss current understanding of the effects of different 3D cell culture systems on proliferation, viability and osteogenic differentiation, as well as on the immunomodulatory and anti-inflammatory potential of MSCs. [Stem Cell Research & Therapy] |
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| Bone Therapeutics and Rigenerand SRL, the biotech company that both develops and manufactures medicinal products for cell therapy applications, primarily for regenerative medicine and oncology, announced the signing of a first agreement for a process development partnership. [Bone Therapeutics] |
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| Institute of Pharmacology and Structural Biology – Toulouse, France |
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| University of Colorado – Aurora, Colorado, United States |
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| The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| Fondazione Human Technopole – Milan, Italy |
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