 | | Vol. 13.03 – 26 January, 2021 |
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| Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is characterized by low T cell infiltration. Scientists studied the cancer-immune interplay in SyS using an integrative approach that combined single-cell RNA sequencing , spatial profiling and genetic and pharmacological perturbations.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors characterized the protein secretome of adipose, bone marrow, placenta, and Wharton’s jelly-derived human MSCs by using conditioned media and analyzing the secretome by mass spectrometry and follow-up bioinformatics.
[International Journal of Molecular Sciences] |
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| Researchers examined the roles of 5-Azacytidine and valproic acid in the dedifferentiation of epithelial cell rests of Malassez into stem-like cells. Additionally, the ability of stem-like cells to differentiate into mesenchymal cells was evaluated.
[Scientific Reports] |
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| Scientists investigated the effects of small extracellular vesicles from adipose derived stromal cells on both chondrocytes and synoviocytes, in order to gain insights into the mechanisms modulating the inflammatory/catabolic osteoarthritis environment.
[Scientific Reports] |
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| Images from previous work, where human Wharton’s Jelly cells were differentiated into mechanosensory hair cells -like cells, were examined. Various cell features were extracted from these images, and those which were pertinent to classification were identified.
[PLoS One] |
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| By means of high-throughput screening of the combinatorial space of mechanical-strain level and of the presence of particular kinase inhibitors, investigators showed that human mesenchymal stem cells could be mechanically and pharmacologically conditioned to enhance vascular regeneration in vivo.
[Nature Biomedical Engineering] |
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| The rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (PHGDH), was examined, and an inverse correlation between PHGDH expression and relapse-free and overall survival in osteosarcoma patients was found.
[Cell Reports] |
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| Scientists assessed the levels of injury, autophagy and inflammasomes in MPTP-induced Parkinson mice models and neurotoxin MPP+-induced cell models after treating them with miR-188-3p-enriched exosomes.
[Molecular Therapy-Nucleic Acids] |
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| The authors suggested that micro-heterogeneity takes part in the fate decision of a mesenchymal cell population involved in the pathogenesis of a genetic disease.
[Cell Death & Disease] |
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| Scientists identified nine miRNAs significantly dysregulated in IFN-γ-primed MSCs, but presented at different levels in their derived small extracellular vesicles.
[Scientific Reports] |
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| The authors evaluated the efficacy of stem cells in maxillary bone regeneration for implant rehabilitation and to review the different techniques for obtaining and processing these cells.
[International Journal of Environmental Research and Public Health] |
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| Scientists investigate and introduce adenosine-producing MSCs as a potential target for cancer treatment.
[Clinical and Experimental Medicine] |
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| Immunicum AB announced that it has received Orphan Drug Designation from the US FDA for the Company’s lead candidate, ilixadencel, a cell-based, off-the-shelf immune primer, for the treatment of Soft Tissue Sarcoma. The designation recognizes results from the Phase I/II clinical trial in Gastrointestinal Stromal Tumors, a rare and difficult-to treat cancer indication belonging to the group of cancers referred to as Soft Tissue Sarcoma.
[Immunicum AB.] |
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| March 14 – 17, 2021
Virtual |
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| | St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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| | Institute of Pharmacology and Structural Biology – Toulouse, France |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | University of Colorado – Aurora, Colorado, United States |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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