 | | Vol. 13.04 – 2 February, 2021 |
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| Scientists demonstrated that neonatal umbilical cord (UC) is a source of extracellular vesicles (EVs) derived from MSCs. These UC-produced MSC-EVs contain abundant anti-aging signals and rejuvenate senescing adult bone marrow-derived MSCs.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Kruppel-like factor 11 (KLF11) recruited SIN3A/HDAC to suppress the transcriptional output of YAP/TEAD, which, in turn, promoted KLF11 transcription, forming a negative feedback loop.
[Science Advances] |
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| Researchers report MSC-derived interleukin-28 (IL-28) triggered prostate cancer cell apoptosis via IL-28 receptor alpha STAT1 signaling.
[Nature Communications] |
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| Scientists performed lineage tracing studies by using various genetic models and found that cardiac mesenchymal cells contribute to cardiac adipocytes in postnatal development and adult homeostasis.
[Cell Reports] |
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| Investigators assessed the immunosuppressive effects of human amnion-derived MSC in a xenogeneic graft-versus host disease NOD/Shi-scid IL2rγnull mouse model using human peripheral blood mononuclear cells.
[Scientific Reports] |
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| The authors describe a flow cytometric assay based on differential immunostaining of target and effector cells where bone marrow MSCs were enumerated with fluorospheres to determine the loss of target cells after co-culture with peripheral blood mononucleated cells.
[Heliyon] |
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| Researchers used a chemical systems biology approach, ligand class analysis, to examine ligands designed to modulate glucocorticoid receptor activity through distinct structural mechanisms.
[Nature Chemical Biology] |
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| The authors explored the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing.
[Nature Communications] |
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| Patients with advanced Ewing sarcoma (AES) carry a poor prognosis. Retrospectively, researchers analyzed 66 AES patients treated with allogeneic stem cell transplantation receiving HLA-mismatched versus HLA-matched grafts.
[Bone Marrow Transplantation] |
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| 30.8% (28/91) of the selected genes showed altered expression and 2/3 of these genes showed positive regulation when compared to public data on gene expression in MSCs of bone marrow tissue in primary myelodysplastic syndrome.
[Scientific Reports] |
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| Investigators discuss current approaches to disc regeneration, with a particular focus on cell-based therapeutic strategies, including ongoing challenges, and attempts to provide a framework to interpret current data and guide future investigational studies.
[Nature Reviews Rheumatology] |
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| The authors review the literature about the differential signaling of lysophosphatidic acid through its specific receptors, which makes this lipid a versatile signaling molecule.
[Signal Transduction and Targeted Therapy] |
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| MSCs demonstrate in vitro and in vivo pro-angiogenic, immuno-suppressive, and anti-fibrotic properties and appear as a promising stem cell therapy type, that may target the key pathological features of systemic sclerosis disease.
[Autoimmunity Reviews] |
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| Sorrento Therapeutics, Inc. announced positive preliminary results from its Phase Ib study of human allogeneic adipose-derived MSCs (COVI-MSCâ„¢) for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome.
[Sorrento Therapeutics, Inc.] |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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| | University of Pennsylvania Perelman School of Medicine – Philadelphia, Pennsylvania, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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