Mesenchymal Cell News Volume 13.05 | Feb 9 2021

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    2020-02-09 | MESCN 13.05


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.05 – 9 February, 2021
    TOP STORY

    Reactivation of the Pluripotency Program Precedes Formation of the Cranial Neural Crest

    Open chromatin landscapes of Oct4+ cranial neural crest cells precursors resembled those of epiblast stem cells, with additional features suggestive of priming for mesenchymal programs.
    [Science]

    Abstract

    Culture mesenchymal stem cells, exosome-free
    PUBLICATIONSRanked by the impact factor of the journal

    Endothelium-Derived Stromal Cells Contribute to Hematopoietic Bone Marrow Niche Formation

    Bone marrow stromal cells play pivotal roles in tissue maintenance and regeneration. Their origins, however, remain incompletely understood. Researchers identified rare LNGFR+ cells in human fetal and regenerative bone marrow that co-expressed endothelial and stromal markers.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Identification of Pannexin 1-Regulated Genes, Interactome, and Pathways in Rhabdomyosarcoma and Its Tumor Inhibitory Interaction with AHNAK

    Scientists surveyed and characterized the molecular changes induced by PANX1 re-expression in rhabdomyosarcoma. They cataloged transcriptomic changes in this context by RNA sequencing.
    [Oncogene]

    Full Article

    MNK1 and MNK2 Enforce Expression of E2F1, FOXM1, and WEE1 to Drive Soft Tissue Sarcoma

    Researchers showed that depletion of either MAP kinase-interacting serine/threonine-protein kinase 1 or 2 (MNK1 or MNK2) suppressed cell viability, anchorage-independent growth, and tumorigenicity of soft tissue sarcoma cells.
    [Oncogene]

    Full Article

    The Delivery of Hsa-miR-11401 by Extracellular Vesicles Can Relieve Doxorubicin-Induced Mesenchymal Stem Cell Apoptosis

    Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage.
    [Stem Cell Research & Therapy]

    Full Article

    Expansion and Characterization of Bone Marrow Derived Human Mesenchymal Stromal Cells in Serum-Free Conditions

    Six different commercially available low serum/serum-free media with two different seeding densities were evaluated to explore their ability to support the growth and expansion of bone marrow (BM)-MSCs and assess the characteristics of BM-MSCs cultured in these media.
    [Scientific Reports]

    Abstract

    High-Resolution 3D Imaging Uncovers Organ-Specific Vascular Control of Tissue Aging

    Scientists performed 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrated an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserved the vasculature.
    [Science Advances]

    Full Article

    Plasmid Encoding MicroRNA-200c Ameliorates Periodontitis and Systemic Inflammation in Obese Mice

    The authors report that highly expressed miR-200c in gingival tissues was downregulated in diet-induced obese mice and during adipogenic differentiation of human bone marrow MSCs.
    [Molecular Therapy-Nucleic Acids]

    Full ArticleGraphical Abstract

    Intravenous Allogeneic Umbilical Cord Blood–Derived Mesenchymal Stem Cell Therapy in Recessive Dystrophic Epidermolysis Bullosa Patients

    In a Phase I/IIa trial, scientists evaluated the safety and possible clinical efficacy of intravenous infusion of allogeneic human umbilical cord blood–derived MSCs in patients with recessive dystrophic epidermolysis bullosa.
    [JCI Insight]

    Full Article

    Allogenic Umbilical Cord Blood-Derived Mesenchymal Stromal Cell Implantation Was Superior to Bone Marrow Aspirate Concentrate Augmentation for Cartilage Regeneration despite Similar Clinical Outcomes

    Investigators compared clinical and second-look arthroscopic outcomes between bone marrow aspirate concentrate augmentation and human umbilical cord blood-derived MSC implantation in high tibial osteotomy for medial compartmental knee osteoarthritis.
    [Knee Surgery, Sports Traumatology, Arthroscopy]

    Abstract

    First Trimester Placental Mesenchymal Stem Cells Improve Cardiac Function of Rat after Myocardial Infarction via Enhanced Neovascularization

    First trimester placental chorion MSCs (CMSCs) and third trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability.
    [Heliyon]

    Full Article

    How to prioritize and manage your research projects
    REVIEWS

    Protecting Islet Functional Viability Using Mesenchymal Stromal Cells

    Scientists focus on recent studies demonstrating the capacity for MSCs to protect islets from hypoxia‐ and cytokine‐induced stress.
    [Stem Cells Translational Medicine]

    Full Article

    Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

    Investigators highlight the safety and efficacy of adipose-derived-MSCs, platelet-rich plasma, and biomaterials on soft tissue defects and chronic wounds, without major side effects.
    [International Journal of Molecular Sciences]

    Full Article

    Pre-Clinical Investigation of Mesenchymal Stromal Cell-Derived Extracellular Vesicles

    The authors classify and critically discuss the technical aspects of MSC-extracellular vesicle (EV) animal studies and discuss potential relationships between methodological details and the effectiveness of MSC-EVs as reported by these pre-clinical studies.
    [Cytotherapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    Fourth Patient Also Released from Hospital following Third Infusion of Stem Cells

    Sorrento Therapeutics, Inc. announced additional positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome.
    [Sorrento Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021: Week 2

    May 17 – 21, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Mesenchymal Niche in Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    Research Assistant – Immune Modulation of MSCs

    National University of Ireland Galway – Galway, Ireland

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Fellowship – Human Cancers

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Professor or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    > See All Jobs

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