| Vol. 13.05 – 9 February, 2021 |
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Open chromatin landscapes of Oct4+ cranial neural crest cells precursors resembled those of epiblast stem cells, with additional features suggestive of priming for mesenchymal programs. [Science] |
| | PUBLICATIONSRanked by the impact factor of the journal |
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| Bone marrow stromal cells play pivotal roles in tissue maintenance and regeneration. Their origins, however, remain incompletely understood. Researchers identified rare LNGFR+ cells in human fetal and regenerative bone marrow that co-expressed endothelial and stromal markers. [Cell Stem Cell] |
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| Scientists surveyed and characterized the molecular changes induced by PANX1 re-expression in rhabdomyosarcoma. They cataloged transcriptomic changes in this context by RNA sequencing. [Oncogene] |
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| Researchers showed that depletion of either MAP kinase-interacting serine/threonine-protein kinase 1 or 2 (MNK1 or MNK2) suppressed cell viability, anchorage-independent growth, and tumorigenicity of soft tissue sarcoma cells. [Oncogene] |
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| Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage. [Stem Cell Research & Therapy] |
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| Six different commercially available low serum/serum-free media with two different seeding densities were evaluated to explore their ability to support the growth and expansion of bone marrow (BM)-MSCs and assess the characteristics of BM-MSCs cultured in these media. [Scientific Reports] |
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| Scientists performed 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrated an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserved the vasculature. [Science Advances] |
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| The authors report that highly expressed miR-200c in gingival tissues was downregulated in diet-induced obese mice and during adipogenic differentiation of human bone marrow MSCs. [Molecular Therapy-Nucleic Acids] |
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| In a Phase I/IIa trial, scientists evaluated the safety and possible clinical efficacy of intravenous infusion of allogeneic human umbilical cord blood–derived MSCs in patients with recessive dystrophic epidermolysis bullosa. [JCI Insight] |
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| Investigators compared clinical and second-look arthroscopic outcomes between bone marrow aspirate concentrate augmentation and human umbilical cord blood-derived MSC implantation in high tibial osteotomy for medial compartmental knee osteoarthritis. [Knee Surgery, Sports Traumatology, Arthroscopy] |
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| First trimester placental chorion MSCs (CMSCs) and third trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability. [Heliyon] |
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| Scientists focus on recent studies demonstrating the capacity for MSCs to protect islets from hypoxia‐ and cytokine‐induced stress. [Stem Cells Translational Medicine] |
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| Investigators highlight the safety and efficacy of adipose-derived-MSCs, platelet-rich plasma, and biomaterials on soft tissue defects and chronic wounds, without major side effects. [International Journal of Molecular Sciences] |
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| The authors classify and critically discuss the technical aspects of MSC-extracellular vesicle (EV) animal studies and discuss potential relationships between methodological details and the effectiveness of MSC-EVs as reported by these pre-clinical studies. [Cytotherapy] |
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| Sorrento Therapeutics, Inc. announced additional positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome. [Sorrento Therapeutics, Inc.] |
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| May 17 – 21, 2021 Virtual |
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| Karolinska Institutet – Flemingsberg, Sweden |
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| National University of Ireland Galway – Galway, Ireland |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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