Mesenchymal Cell News Volume 13.06 | Feb 16 2021

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    2020-02-16 | MESCN 13.06


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.06 – 16 February, 2021
    TOP STORY

    Loss of KDM4B Exacerbates Bone-Fat Imbalance and Mesenchymal Stromal Cell Exhaustion in Skeletal Aging

    Scientists report that loss of KDM4B in MSCs exacerbated skeletal aging and osteoporosis by reducing bone formation and increasing marrow adiposity via increasing H3K9me3.
    [Cell Stem Cell]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    CD10 Marks Non-Canonical PPARγ-Independent Adipocyte Maturation and Browning Potential of Adipose-Derived Stem Cells

    Investigators identified intrinsic CD10 levels as a positive determinant of adipocyte maturation as well as browning potential of human adipose-derived stem cells.
    [Stem Cell Research & Therapy]

    Full Article

    Pluripotency and Immunomodulatory Signatures of Canine Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells Are Similar to Harvested Mesenchymal Stromal Cells

    With a view towards harnessing the therapeutic potential of canine (c)MSCs as modulators of inflammation and the immune response, and to avoid the issues of the variable quality and quantity of harvested cMSCs, scientists examined the immunomodulatory properties of cMSCs derived from canine induced pluripotent stem cells, and compared them to cMSCs harvested from adipose tissue and bone marrow.
    [Scientific Reports]

    Full Article

    Mechano-Activation of Mesenchymal Stem Cells by Avoiding Intracellular Tensional Equilibrium on Matrix with Stiffness-Heterogeneity

    The authors showed that the MSCs nomadically migrating on a microelastically-patterned matrix with stiffness-heterogeneity markedly amplified intracellular stress dynamics fluctuations and clearly activated a wide variety of gene expressions relating to vigorousness of the cell.
    [Biophysical Journal]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP

    Researchers investigated the effect of exosomes and miR-18b-3p/leptin (LEP) on occurrence of preeclampsia. The morphology of the human umbilical cord (hUC) MSCs and hucMSC-exosomes was identified.
    [Nanoscale Research Letters]

    Full Article

    Mesenchymal Stromal Cells Attenuate Post-Stroke Infection by Preventing Caspase-1-Dependent Splenic Marginal Zone B Cell Death

    Scientists showed that intravenously administered MSCs preferentially migrate to the marginal zone (MZ) of the spleen, preserving injured MZ B cells and ameliorating post-stroke infection and mortality in the mouse middle cerebral artery occlusion model of acute ischemic stroke.
    [Signal Transduction and Targeted Therapy]

    Full Article

    The Molecular Conformation of Silk Fibroin Regulates Osteogenic Cell Behavior by Modulating the Stability of the Adsorbed Protein-Material Interface

    Osteogenic differentiation of bone marrow (BM)-MSCs was stimulated on high β-sheet substrates. Investigators indicated that the β-sheet content influences osteogenic differentiation of BMSCs on silk fibroin materials in vitro by modulating the stability of the adsorbed protein-material interface, which proceeds via protein-focal adhesion-cytoskeleton links and subsequent intracellular mechanotransduction.
    [Bone Research]

    Full Article

    Clinical Implications of Systemic and Local Immune Responses in Human Angiosarcoma

    Angiosarcomas are a rare subtype of soft-tissue sarcomas which exhibit aggressive clinical phenotypes with limited treatment options and poor outcomes. The authors investigated the clinical relevance of the peripheral blood neutrophil-to-lymphocyte ratio as a marker of systemic immune response
    [npj Precision Oncology]

    Full Article

    TRPM8 Channel Inhibitor-Encapsulated Hydrogel as a Tunable Surface for Bone Tissue Engineering

    Investigators showed that osteoblasts and bone marrow-MSC pools expressed TRPM8, a Ca2+-ion channel critical for bone-mineralization. TRPM8 inhibition triggered up-regulation of key osteogenesis factors; and increased mineralization by osteoblasts.
    [Scientific Reports]

    Full Article

    Culture mesenchymal stem cells, exosome-free
    REVIEWS

    Mesenchymal Stem Cells and Oncolytic Viruses: Joining Forces against Cancer

    The author reviews the current progress of oncolytic viruses-loaded MSCs in cancer, focusing on their interaction with the immune system, and discusses new strategies to improve their therapeutic efficacy.
    [Journal for ImmunoTherapy of Cancer]

    Full Article

    Mesenchymal Stromal Cell Immunomodulation: In Pursuit of Controlling COVID‐19 Related Cytokine Storm

    Scientists present an overview and perspectives of the SARS‐CoV‐2 induced inflammatory dysfunction and the potential of MSC immunomodulation for the prevention and treatment of COVID‐19 related pulmonary disease.
    [Stem Cells]

    Abstract

    INDUSTRY AND POLICY NEWS

    Mesoblast Phase III Trial Shows That a Single Injection of Rexlemestrocel-L + Hyaluronic Acid Carrier Results in at Least Two Years of Pain Reduction with Opioid Sparing Activity in Patients with Chronic Low Back Pain Due to Degenerative Disc Disease

    Mesoblast Limited announced results from the Phase III randomized controlled trial of its allogeneic mesenchymal precursor cell (MPC) therapy rexlemestrocel-L in 404 enrolled patients with chronic low back pain due to degenerative disc disease refractory to conventional treatments.
    [Mesoblast, Ltd.]

    Press Release

    FEATURED EVENT

    ISEV2021 Annual Meeting

    May 18 – 21, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Position – Osteoporosis

    University of Southern Denmark – Odense M, Denmark

    Research Assistant – Immune Modulation of MSCs

    National University of Ireland Galway – Galway, Ireland

    Postdoctoral Researcher – Mesenchymal Niche in Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Fellowship – Human Cancers

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    > See All Jobs

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