Mesenchymal Cell News Volume 13.11 | Mar 23 2021

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    MESCN 13.11 | Mar 23 2021


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.11 – 23 March, 2021
    TOP STORY

    Mesenchymal Stem Cell‐Derived Extracellular Vesicles Reduce Senescence and Extend Health Span in Mouse Models of Aging

    Injection of bone marrow‐derived (BM)‐MSCs from young mice prolonged life span and health span, and conditioned media from young BM‐MSCs rescued the function of aged stem cells and senescent fibroblasts.
    [Aging Cell]

    Full Article

    Webinar: Bone Marrow Skeletal Progenitors and Bone Diseases
    PUBLICATIONSRanked by the impact factor of the journal

    Human Placenta Mesenchymal Stem Cell-Derived Exosomes Delay H2O2-Induced Aging in Mouse Cholangioids

    Researchers investigated whether human placenta MSC-derived exosomes exerted a protective effect in senescent cholangiocyte organoids.
    [Stem Cell Research & Therapy]

    Full Article

    Adipose-Derived Stromal/Stem Cell Culture: Effects of Different Concentrations of Human Platelet Lysate in Media

    Scientists investigated the effect of five, ten, or 20% pooled human platelet lysate in culture media on adipose-derived stromal/stem cell proliferation and phenotypic marker expression.
    [Cells Tissues Organs]

    Abstract

    Allogeneic Adipose‐Derived Stem Cells Mitigate Acute Radiation Syndrome by the Rescue of Damaged Bone Marrow Cells from Apoptosis

    Investigators evaluated the therapeutic potential of allogeneic adipose‐derived stem cells for total body irradiation‐induced acute radiation syndrome and studied the underlying mitigation mechanism.
    [Stem Cells Translational Medicine]

    Full ArticlePress Release

    Bone Marrow‐Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating ISL1

    Researchers identified the insulin gene enhancer binding protein‐1 protein as a potential modulator in bone marrow‐derived MSC‐mediated revascularization of islet grafts.
    [Stem Cells]

    Abstract

    Wnt/β-Catenin Signaling Mediates the Abnormal Osteogenic and Adipogenic Capabilities of Bone Marrow Mesenchymal Stem Cells from Chronic Graft-versus-Host Disease Patients

    Scientists analyzed bone marrow-MSCs from 66 patients after allo-hematopoietic stem cell transplantation, including 33 with active chronic graft-versus-host disease and 33 without chronic graft-versus-host disease.
    [Cell Death & Disease]

    Full Article

    Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth

    The authors exploited Cxcl12-GFP transgenic mice to study the expression patterns of Cxcl12 in putative dental niches of intact and injured teeth.
    [International Journal of Molecular Sciences]

    Full Article

    Effect of Mesenchymal Stromal Cells Encapsulated within Polyethylene Glycol-Collagen Hydrogels Formed In Situ on Alkali-Burned Corneas in an Ex Vivo Organ Culture Model

    Human MSCs were added to a neutralized collagen solution and mixed with a solution of four-arm polyethylene glycol-N-hydroxysuccinimide.
    [Cytotherapy]

    Abstract

    Latest updates and debates on mesenchymal stem cells.
    REVIEWS

    Heterogeneity of Mesenchymal Stem Cells in Cartilage Regeneration: From Characterization to Application

    This review provides an overview of the heterogeneity of MSCs at the donor, tissue source and cell immunophenotype levels, including their cytological properties, such as their ability for proliferation, chondrogenic differentiation and immunoregulation.
    [NPJ Regenerative Medicine]

    Full Article

    Mesenchymal Stem/Stromal Cells as a Valuable Source for the Treatment of Immune-Mediated Disorders

    The authors discuss the therapeutic applications of mesenchymal stem/stromal cell secretome and its biomedical aspects related to immune-mediated conditions.
    [Stem Cell Research & Therapy]

    Full Article

    The Vital Roles of Mesenchymal Stem Cells and the Derived Extracellular Vesicles in Promoting Angiogenesis after Acute Myocardial Infarction

    Scientists highlight potential pro-angiogenic mechanisms of transplanted MSCs and the derived EVs after acute myocardial infarction and summarize the latest literature concerning the novel methods based on MSCs to maximize the angiogenesis capability.
    [Stem Cells and Development]

    Abstract

    INDUSTRY AND POLICY NEWS

    BioRestorative Therapies Announces Notices of Allowance for Three Patent Applications for Its Off-the-Shelf ThermoStem® Program

    BioRestorative Therapies, Inc. announced that the United States Patent Office and several International agencies have issued notices of allowance for three separate patent applications related to the Company’s metabolic ThermoStem® Program.
    [BioRestorative Therapies, Inc. (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Metabolism in Health and Disease

    June 28 – 30, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – 3D-Printing & Scaffold Design in ​Neural Tissue

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Position – Gene and Cell Therapy Development for Treatment of Primary Immune Deficiencies

    NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Postdoctoral Fellow Position – Collagen Receptors in Bone Development and Regeneration

    University of Michigan – Ann Arbor, Michigan, United States

    Postdoctoral Fellow Position – Sarcoma Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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