Mesenchymal Cell News Volume 13.13 | Apr 6 2021

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    2021-04-6 | MESCN 13.13


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.13 – 06 April, 2021
    TOP STORY

    C3G Downregulation Induces the Acquisition of a Mesenchymal Phenotype That Enhances Aggressiveness of Glioblastoma Cells

    The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
    [Cell Death & Disease]

    Full Article
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

    Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
    [Stem Cell Reports]

    Full Article

    Single-Cell Transcriptome Profiling Reveals Molecular Heterogeneity in Human Umbilical Cord Tissue and Culture-Expanded Mesenchymal Stem Cells

    The heterogeneity and the characteristics of cultured umbilical cord MSCs and the cognate human umbilical cord tissue at single‐cell resolution remains poorly defined.
    [FEBS Journal]

    Abstract

    IL-1β Mediated Nanoscale Surface Clustering of Integrin α5β1 Regulates the Adhesion of Mesenchymal Stem Cells

    Scientists found that IL-1β enhanced adhesion of human MSCs via increased focal adhesion contacts in an α5β1 integrin-specific manner.
    [Scientific Reports]

    Full Article

    IL-1β Mediated Nanoscale Surface Clustering of Integrin α5β1 Regulates the Adhesion of Mesenchymal Stem Cells

    Researchers found that IL-1β enhanced adhesion of human MSCs via increased focal adhesion contacts in an α5β1 integrin-specific manner.
    [Scientific Reports]

    Full Article

    Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

    Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
    [Cancer Biotherapy and Radiopharmaceuticals]

    Abstract

    Exosome-Eluting Stents for Vascular Healing after Ischemic Injury

    The authors showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhanced vascular healing in rats with renal ischemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
    [Nature Biomedical Engineering]

    Abstract

    Healthy versus Inflamed Lung Environments Differentially Effect MSCs

    Researchers comparatively assessed how the inflammatory environment present in acute respiratory distress syndrome (ARDS) lungs versus the lung environment present in healthy volunteers alters MSC behaviors.
    [European Respiratory Journal]

    Abstract

    Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease

    Five groups of pigs were studied after 16 weeks of renovascular disease (RVD), RVD treated four weeks earlier with either percutaneous transluminal renal angioplasty or MSC-derived extracellular vesicles, and normal controls.
    [Cells]

    Full Article

    Dual Effects of Hypoxia on Proliferation and Osteogenic Differentiation of Mouse Clonal Mesenchymal Stem Cells

    Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.
    [Bioprocess and Biosystems Engineering]

    Abstract
    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

    The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Athersys Reports That Healios Has Completed Enrollment in the ONE-BRIDGE Study of MultiStem® for Acute Respiratory Distress Syndrome in Japan

    Athersys, Inc. announced that its partner HEALIOS K.K. has completed enrollment in the ONE-BRIDGE study in Japan evaluating MultiStem® in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia.
    [Athersys, Inc]

    Press Release
    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Fellow or Research Scientist – Cell and Gene Therapy of Cancer

    Rutgers University – New Brunswick, New Jersey, United States

    Scientist/Engineer – Matrix Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – MSCs in Female Infertility Disorders

    University of Chicago – Chicago, Illinois, United States

    Research Fellow – 3D-Printing & Scaffold Design in ​Neural Tissue

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Position – Gene and Cell Therapy Development for Treatment of Primary Immune Deficiencies

    NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    > See All Jobs

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