Mesenchymal Cell News Volume 13.14 | Apr 13 2021

    By
    Justin.choi
    -
    0
    36







    2021-04-13 | MESCN 13.14


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.14 – 13 April, 2021
    TOP STORY

    Systemic Administration of Mesenchymal Stem Cells Loaded with a Novel Oncolytic Adenovirus Carrying IL-24/Endostatin Enhances Glioma Therapy

    Investigators developed an all-in-one Tet-on system that could regulate replication of oncolytic adenovirus.
    [Cancer Letters]

    Abstract
    Stem Cell Conference Registration Award
    PUBLICATIONSRanked by the impact factor of the journal

    Novel BRAF Gene Fusions and Activating Point Mutations in Spindle Cell Sarcomas with Histologic Overlap with Infantile Fibrosarcoma

    The authors report the clinicopathologic and molecular features of 14 BRAF-altered tumors, of which five had BRAF point mutations and ten harbored one or more BRAF fusions.
    [Modern Pathology]

    Abstract

    Adipose-Derived Stem Cells Combined with Platelet-Rich Plasma Enhance Wound Healing in a Rat Model of Full-Thickness Skin Defects

    Researchers hypothesized that the combination of adipose-derived stem cells and platelet-rich plasma might achieve optimally efficient diabetic wound healing.
    [Stem Cell Research & Therapy]

    Full Article

    Glucose-Dependent Insulinotropic Polypeptide Modifies Adipose Plasticity and Promotes Beige Adipogenesis of Human Omental Adipose-Derived Stem Cells

    Scientists explored the in vitro actions and mechanisms of glucose‐dependent insulinotropic polypeptide, a gut‐derived peptide, in human adipose‐derived MSCs isolated from omentum.
    [FASEB Journal]

    Abstract

    Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

    The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
    [International Journal of Molecular Sciences]

    Full Article

    A Single Cell Atlas of Human Teeth

    Researchers mapped the transcriptional landscape of the various cell populations that compose human teeth at single-cell resolution, and analyzed in deeper detail their stem cell populations and their microenvironment.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Assessment of the Neuroprotective and Stemness Properties of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells under Variable (5% vs. 21%) Aerobic Conditions

    Scientists investigated ten different properties of Wharton’s jelly-derived MSCs cells cultured under 21% and 5% oxygen concentrations.
    [Cells]

    Full ArticleGraphical Abstract

    Effect of Long-Term 3D Spheroid Culture on WJ-MSC

    Investigators developed a protocol enabling a derivation of MSC subpopulation with increased expression of pluripotent and neural genes.
    [Cells]

    Full ArticleGraphical Abstract

    Mesenchymal Stem Cells Accelerated Growth and Metastasis of Neuroblastoma and Preferentially Homed towards Both Primary and Metastatic Loci in Orthotopic Neuroblastoma Model

    Human MSCs mixed with neuroblastoma cells significantly accelerated tumor growth and apparently enhanced metastasis of neuroblastoma in vivo.
    [BMC Cancer]

    Full Article

    Transplantation of Human Amniotic Epithelial Cells Promotes Morphological and Functional Regeneration in a Rat Uterine Scar Model

    Scientists investigated whether human amniotic epithelial cells transplantation has the therapeutic effects on the rat uterine scar following full-thickness injury.
    [Stem Cell Research & Therapy]

    Full Article

    ON831CC_645x110-ebook
    REVIEWS

    The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

    The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
    [International Journal of Molecular Sciences]

    Full Article

    Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine

    Several limitations of MSC as cell therapy are recognized, such as safety issues, handling difficulties for therapeutic purposes, and high economic cost.
    [International Journal of Molecular Sciences]

    Abstract

    INDUSTRY AND POLICY NEWS

    Sentien Biotechnologies Completes Enrollment of First Cohort in Phase I/II Trial of Ex Vivo MSC Therapy for the Treatment of Severe COVID-19

    Sentien Biotechnologies, Inc. announced it has completed enrollment of the first cohort in its Phase I/II study of SBI-101 for the treatment of severe COVID-19. SBI-101 is being evaluated in COVID-19 patients suffering from both acute respiratory distress syndrome and acute kidney injur requiring renal replacement therapy.
    [Sentien Biotechnologies, Inc.]

    Press Release
    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Vascular Networks

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Scientist/Engineer – Matrix Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – MSCs in Female Infertility Disorders

    University of Chicago – Chicago, Illinois, United States

    Research Fellow – 3D-Printing & Scaffold Design in ​Neural Tissue

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Position – Gene and Cell Therapy Development for Treatment of Primary Immune Deficiencies

    NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mesenchymal Cell News Twitter