| Vol. 13.15 – 20 April, 2021 |
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| The inclusion of alginate sulfate had a limited influence on the viscosity, shear-thinning, and thixotropic properties of the interpenetrating network bioink, enabling high-fidelity bioprinting and supporting MSC viability post-printing. [Acta Biomaterialia] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that the knockdown of MSC enriched U1-5′ snsRNA promoted hepatic reprogramming. CPA-seq is a powerful tool with high sensitivity and specificity for profiling sRNAs with methylated nucleosides and diverse termini. [Cell Discovery] |
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| The authors found that transcriptional coactivator with PDZ-binding motif (TAZ) expression gradually increased during chondrogenic differentiation. [Cell Discovery] |
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| It was shown that gingival MSCs’ sensitivity to oxidative stress depended on the stiffness of the surface, on which the cells were grown. [Free Radical Biology and Medicine] |
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| Investigators describe three unclassified spindle cell sarcomas with a monomorphic cytomorphology and distinctive storiform growth, characterized by novel fusions between EWSR1 or FUS1, and NACC1 genes. [Modern Pathology] |
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| The authors used adult female rat adipose-derived stem cells and human MSCs to compare the toxicities and potencies of bisphenol A (BPA) alternatives in vitro. [Ecotoxicology and Environmental Safety] |
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| Researchers showed that adipose-derived MSCs produced interleukin-33 (IL-33) in response to IL-1β stimulation, which depended on TAK1, ERK, and p38 pathways. [iScience] |
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| MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20°C that induced a surface wettability transition from hydrophobic to hydrophilic. [Scientific Reports] |
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| The capability of extracellular vesicles (EVs) was leveraged to be engineered via producer cell modification to investigate the therapeutic potential of EVs from mesenchymal stem/stromal cells transfected to overexpress long non‐coding RNA HOX transcript antisense RNA (HOTAIR). [Advanced Healthcare Materials] |
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| Investigators evaluated the safety and feasibility of using MSCs to replace rituximab in ABO-incompatible liver transplantation. [Stem Cell Research & Therapy] |
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| Using ChIP-Seq against NACA in parallel with RNA-sequencing, researchers report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts. [Scientific Reports] |
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| Scientists summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs. [Journal of Biomedical Science] |
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| The authors highlight the impact and recent trends in employing biological and chemical inducers on cardiac differentiation of MSCs. [Stem Cell Reviews and Reports] |
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| Boehringer Ingelheim and The University of Texas MD Anderson Cancer Center announced the extension and expansion of their joint Virtual Research and Development Center to explore new molecules from Boehringer Ingelheim’s Kirsten rat sarcoma (KRAS) and TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) portfolios for the potential treatment of lung cancer, particularly non-small cell lung cancer. [Boehringer Ingelheim] |
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| Two University of Arkansas researchers received a $480,000 National Science Foundation grant to investigate how engineered coatings that imitate the tissue matrix surrounding cells would affect the behavior of therapeutic human MSCs. [University of Arkansas] |
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| A new ruling removes the requirement that grants and proposals using the material receive approval from an ethical review board, reverting to the process in place before 2019. [The Scientist] |
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| October 27 – 29, 2021 Tokyo, Japan |
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| National University of Ireland Galway – Galway, Ireland |
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| University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| CyberCoders – San Diego, California, United States |
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