Mesenchymal Cell News Volume 13.15 | Apr 20 2021

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    2021-04-20 | MESCN 13.15


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.15 – 20 April, 2021
    TOP STORY

    Affinity-Bound Growth Factor within Sulfated Interpenetrate Network Bioinks for Bioprinting Cartilaginous Tissues

    The inclusion of alginate sulfate had a limited influence on the viscosity, shear-thinning, and thixotropic properties of the interpenetrating network bioink, enabling high-fidelity bioprinting and supporting MSC viability post-printing.
    [Acta Biomaterialia]

    Full Article

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    CPA-Seq Reveals Small ncRNAs with Methylated Nucleosides and Diverse Termini

    Scientists found that the knockdown of MSC enriched U1-5′ snsRNA promoted hepatic reprogramming. CPA-seq is a powerful tool with high sensitivity and specificity for profiling sRNAs with methylated nucleosides and diverse termini.
    [Cell Discovery]

    Full Article

    TAZ Is Required for Chondrogenesis and Skeletal Development

    The authors found that transcriptional coactivator with PDZ-binding motif (TAZ) expression gradually increased during chondrogenic differentiation.
    [Cell Discovery]

    Full Article

    Surface Stiffness Depended Gingival Mesenchymal Stem Cell Sensitivity to Oxidative Stress

    It was shown that gingival MSCs’ sensitivity to oxidative stress depended on the stiffness of the surface, on which the cells were grown.
    [Free Radical Biology and Medicine]

    AbstractGraphical Abstract

    Unclassified Low Grade Spindle Cell Sarcoma with Storiform Pattern Characterized by Recurrent Novel EWSR1/FUS-NACC1 Fusions

    Investigators describe three unclassified spindle cell sarcomas with a monomorphic cytomorphology and distinctive storiform growth, characterized by novel fusions between EWSR1 or FUS1, and NACC1 genes.
    [Modern Pathology]

    Abstract

    BPA and BPA Alternatives BPS, BPAF, and TMBPF, Induce Cytotoxicity and Apoptosis in Rat and Human Stem Cells

    The authors used adult female rat adipose-derived stem cells and human MSCs to compare the toxicities and potencies of bisphenol A (BPA) alternatives in vitro.
    [Ecotoxicology and Environmental Safety]

    Full ArticleGraphical Abstract

    Adipose-Mesenchymal Stromal Cells Suppress Experimental Sjogren’s Syndrome by IL-33-Driven Expansion of ST2+ Regulatory T Cells

    Researchers showed that adipose-derived MSCs produced interleukin-33 (IL-33) in response to IL-1β stimulation, which depended on TAK1, ERK, and p38 pathways.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    3D Cell Sheet Structure Augments Mesenchymal Stem Cell Cytokine Production

    MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20°C that induced a surface wettability transition from hydrophobic to hydrophilic.
    [Scientific Reports]

    Full Article

    HOTAIR‐Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing

    The capability of extracellular vesicles (EVs) was leveraged to be engineered via producer cell modification to investigate the therapeutic potential of EVs from mesenchymal stem/stromal cells transfected to overexpress long non‐coding RNA HOX transcript antisense RNA (HOTAIR).
    [Advanced Healthcare Materials]

    Abstract

    A Novel MSC-Based Immune Induction Strategy for ABO-Incompatible Liver Transplantation: A Phase I/II Randomized, Open-Label, Controlled Trial

    Investigators evaluated the safety and feasibility of using MSCs to replace rituximab in ABO-incompatible liver transplantation.
    [Stem Cell Research & Therapy]

    Full Article

    Ubiquitin Specific Peptidase Usp53 Regulates Osteoblast versus Adipocyte Lineage Commitment

    Using ChIP-Seq against NACA in parallel with RNA-sequencing, researchers report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.
    [Scientific Reports]

    Full Article

    Culture mesenchymal stem cells, exosome-free
    REVIEWS

    Mesenchymal Stem/Stromal Cell-Based Therapy: Mechanism, Systemic Safety and Biodistribution for Precision Clinical Applications

    Scientists summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs.
    [Journal of Biomedical Science]

    Full Article

    Cardiac Differentiation of Mesenchymal Stem Cells: Impact of Biological and Chemical Inducers

    The authors highlight the impact and recent trends in employing biological and chemical inducers on cardiac differentiation of MSCs.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Boehringer Ingelheim and MD Anderson Expand Collaboration to Accelerate Development of KRAS and TRAILR2 Compounds in Lung Cancer

    Boehringer Ingelheim and The University of Texas MD Anderson Cancer Center announced the extension and expansion of their joint Virtual Research and Development Center to explore new molecules from Boehringer Ingelheim’s Kirsten rat sarcoma (KRAS) and TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) portfolios for the potential treatment of lung cancer, particularly non-small cell lung cancer.
    [Boehringer Ingelheim]

    Press Release

    Researchers Receive Grant to Improve Cellular Therapies to Treat ‘Incurable’ Diseases

    Two University of Arkansas researchers received a $480,000 National Science Foundation grant to investigate how engineered coatings that imitate the tissue matrix surrounding cells would affect the behavior of therapeutic human MSCs.
    [University of Arkansas]

    Press Release

    NIH Reverses Limits on Human Fetal Tissue Research

    A new ruling removes the requirement that grants and proposals using the material receive approval from an ethical review board, reverting to the process in place before 2019.
    [The Scientist]

    Full Article

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Starstem NanoSTARS

    National University of Ireland Galway – Galway, Ireland

    Assistant/Associate/Professor – Oral Biology

    University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Scientist/Engineer – Matrix Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Fellow Position – Sarcoma Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

    > See All Jobs

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