 | | Vol. 13.16 – 27 April, 2021 |
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| Using cells adhering to deformable micropillar arrays, the authors demonstrated that traction force and FAK localization as well as traction force and Y397-FAK phosphorylation were linearly coupled at individual focal adhesions on stiff, but not soft, substrates.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the significance of the mode of immune-escape on T cells engineered to express chimeric antigen receptors (CAR-T) cells.
[Clinical Cancer Research] |
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| Researchers examined the efficacy of MSC-dressings using human amniotic membrane-derived MSCs and the underpinning mechanism for myocardial repair.
[Molecular Therapy] |
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| 3D decellularized extracellular matrix scaffolds derived from MSC spheroids and with intricate matrix composition were developed.
[Advanced Healthcare Materials] |
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| Long non-coding RNAs (lncRNAs) are differentially expressed in inflamed human dental pulp tissues. The authors investigated the role of lncRNA H19 in the differentiation potential of human dental pulp stem cells.
[Molecular Therapy-Nucleic Acids] |
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| Investigators assayed the protein cargo transported from multiple myeloma (MM)-MSCs to MM cells via microvesicles with a focus on ribosomal proteins and assessment of their influence on translation initiation and design of MM phenotype.
[Translational Research] |
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| A biomimetic scaffold was developed that allowed rapid and self‐sustained endochondral ossification without initial hypertrophic chondrogenesis.
[Advanced Healthcare Materials] |
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| Scientists investigated the therapeutic efficacy of MSCs for bronchopulmonary dysplasia in premature infants. A Phase II double‐blind, randomized, placebo‐controlled clinical trial was conducted on preterm infants at 23 to 28 gestational weeks receiving mechanical ventilator support.
[Stem Cells Translational Medicine] |
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| Researchers found osteogenic cells from aged rats all exhibited senescence changes, with the most pronounced senescence changes in osteocytes. Meanwhile, the proliferative capacity and functional activity of osteogenic cells from aged rats were suppressed.
[Aging] |
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| To investigate the functions of exosomes derived from human umbilical cord MSC (hucMSC-ex) in a rat model of acute skin photodamage, immunofluorescence, immunohistochemical staining, quantitative real-time-polymerase chain reaction, western blot, and gene silencing assays were performed.
[Aging] |
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| Investigators compared extracellular vesicles derived from multiple human mesenchymal stem cell and cardiosphere-derived cell donors using diverse in vitro and in vivo assays.
[Scientific Reports] |
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| Scientists assessed the use of a beta-tricalcium phosphate scaffold loaded with high mobility group box-1 protein (HMGB-1) as a novel critical-sized bone defect treatment in rabbits.
[Scientific Reports] |
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| Investigators present a therapeutic platform of MSC-derived exosomes equipped with exogenous iRNAs, that can be employed as a novel therapeutic modality in COVID-19 management.
[Journal of Translational Medicine] |
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| Organicell Regenerative Medicine, Inc. announced that the FDA has approved the Investigational New Drug (IND) application for its lead product, Zofin™, in the treatment of knee osteoarthritis.
[Organicell Regenerative Medicine, Inc.] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| | Zhejiang University – Zhejiang, China |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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