 | | Vol. 13.18 – 11 May, 2021 |
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| The authors reported that after distinct types of intestinal epithelial damage, IL-1R1 signaling in GREM1+ mesenchymal cells increased production of R-spondin 3, a Wnt agonist required for intestinal stem cell self-renewal.
[Science Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that extracellular vesicles released by neoplastic mast cells and present in the serum of patients with systemic mastocytosis blocked osteoblast differentiation and mineralization in culture, and when injected into mice diminished the expression of osteoblast markers, and trabecular bone volume and microarchitecture.
[Nature Communications] |
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| Investigators evaluated the chondrogenic differentiation potential of menstrual blood-derived MSCs and bone marrow MSCs stimulated with transforming growth factor β (TGF-β3) and activin A.
[Stem Cell Research & Therapy] |
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| The injectable alginate-based microporous hydrogel was used to deliver 5-Azacytidine in zein protein nanoparticle with MSCs for attenuating adverse cardiac remodeling after myocardial infarction.
[International Journal of Pharmaceutics] |
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| Scientists determined the therapeutic potential of different human adipose tissue-derived-MSCs doses or their secreted extracellular vesicles, on human microglial cells that were activated by lipopolysaccharides.
[Cell Death Discovery] |
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| Investigators elucidated whether thawed cryopreserved MSCs show comparable inhibitory effects on osteoarthritis progression in rats to those obtained with cultured MSCs.
[Scientific Reports] |
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| Researchers used multi-omics and computational tools to analyze multiple bone marrow environmental compartments and deciphered their mutual interactions in the context of acute myeloid leukemia xenografts.
[Cell Reports] |
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| The authors demonstrated that human marrow‐derived MSCs were antimicrobial and anti‐inflammatory in vitro and in the context of an in vivo sustained infection of either Mycobacterium avium and/or Mycobacterium intracellulare.
[Stem Cells Translational Medicine] |
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| Initial experience with Temcell, a cryopreserved human bone marrow-derived MSC product, in a real-world setting from a cellular therapy registry in Japan is presented.
[Bone Marrow Transplantation] |
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| Researchers evaluated the performance and quality of cancer treatment based on MSCs loaded by oncolytic reovirus in the cancerous C57BL/6 mouse model.
[Cancer Cell International] |
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| Scientists investigated proliferating cells in mouse molar periodontal ligament during orthodontic tooth movement-induced tissue remodeling.
[Scientific Reports] |
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| The authors compile and discuss study design data from ongoing clinical trials to address the key questions of ‘which’ tissue source, donor profile, isolation technique, culture conditions, long-term culture, and cryopreservation for MSCs.
[Cytotherapy] |
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| Scientists discuss the current status of research into small molecular inhibitors against D-3-phosphoglycerate dehydrogenase in colorectal cancer, breast cancer, and Ewing’s sarcoma.
[Cell Death Discovery] |
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| Investigators improve the understanding of the role of histone modifications in osteogenic differentiation and describe its potential as a therapeutic target for osteogenic differentiation-related diseases.
[Cell Death Discovery] |
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| Therapeutic Solutions International, Inc. and its subsidiary Campbell Neurosciences announced new data covered by its previously filed patents supporting the use of mesenchymal-based stem cell therapy for schizophrenia.
[Therapeutic Solutions International, Inc. (Cision US, Inc.)] |
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| Cryo-Cell International, Inc. Medical Director, Dr. Joanne Kurtzberg and her research team at Duke University School of Medicine are currently conducting two major studies: MASC (Phase I/II) & MISTIC (Phase I) to treat, respectively, COVID-19 related Acute Respiratory Distress Syndrome and COVID-19 associated Multisystem Inflammatory Syndrome in Children.
[Cryo-Cell International, Inc.] |
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| January 16 – 21, 2022
Galveston, Texas, United States |
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| | Astellas Pharma – Westborough, Massachusetts, United States |
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| | Elsevier – Cambridge, Massachusetts, United States |
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| | Washington University in St. Louis – Saint Louis, Missouri, United States |
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| | Columbia University Medical Center – New York City, New York, United States |
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| | Zhejiang University – Zhejiang, China |
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