Mesenchymal Cell News Volume 13.19 | May 18 2021

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    2021-05-18 | MESCN 13.19


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.19 – 18 May, 2021
    TOP STORY

    Mesenchymal Stromal Exosome-Functionalized Scaffolds Induce Innate and Adaptive Immunomodulatory Responses toward Tissue Repair

    Biofunctional scaffolds were prepared by immobilizing mesenchymal stromal exosomes onto fibrous polyester materials and allowed cell-mediated delivery of membrane-bound vesicles.
    [Science Advances]

    Full Article


    Watch this lively panel discussion about genome editing & genome integrity at the Nature Research Round Table on hPSC Quality
    PUBLICATIONSRanked by the impact factor of the journal

    TRPM7 Kinase-Mediated Immunomodulation in Macrophage Plays a Central Role in Magnesium Ion-Induced Bone Regeneration

    Researchers established a paradigm shift in the understanding of the diverse and multifaceted roles of magnesium ion in bone healing.
    [Nature Communications]

    Full Article

    ETV4/5 Drive Synovial Sarcoma through Control of the Cell Cycle and the DUX4 Embryonic Pathway

    In genetic FGFR knockout models, culture, and xenograft synovial sarcoma models treated with the FGFR inhibitor BGJ398, scientists showed that FGFR1, FGFR2, and FGFR3 were crucial for tumor growth.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    Luspatercept Restores SDF-1-Mediated Hematopoietic Support by MDS-Derived Mesenchymal Stromal Cells

    The authors investigated whether luspatercept could modulate the functional properties of MSCs as key components of the bone marrow microenvironment.
    [Leukemia]

    Full Article

    Exosomal circ_0030167 Derived from BM-MSCs Inhibits the Invasion, Migration, Proliferation and Stemness of Pancreatic Cancer Cells by Sponging miR-338-5p and Targeting the Wif1/Wnt8/β-Catenin Axis

    Researchers found that bone marrow-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of pancreatic cancer cells, as well as tumor stemness.
    [Cancer Letters]

    Abstract

    Adropin-Based Dual Treatment Enhances the Therapeutic Potential of Mesenchymal Stem Cells in Rat Myocardial Infarction

    Adropin in vitro reduced hydrogen peroxide-induced apoptosis in rat bone marrow MSCs and improved MSC survival with increased phosphorylation of Akt and extracellular regulated protein kinases.
    [Cell Death & Disease]

    Full Article

    Direct Contribution of Skeletal Muscle Mesenchymal Progenitors to Bone Repair

    Investigators showed that mesenchymal progenitors residing in skeletal muscle mediated the initial fibrotic response to bone injury and also participated in cartilage and bone formation.
    [Nature Communications]

    Full Article

    Kartogenin Prevents Cartilage Degradation and Alleviates Osteoarthritis Progression in Mice via the miR-146a/NRF2 Axis

    Scientists explored the protective effects and underlying mechanisms of kartogenin on articular cartilage degradation using mice with post-traumatic osteoarthritis.
    [Cell Death & Disease]

    Full Article

    Mesenchymal Stromal Cells Reduce Evidence of Lung Injury in Patients with ARDS

    Investigators carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS.
    [JCI Insight]

    AbstractFull Article

    Alternative Regulatory Mechanism for the Maintenance of Bone Homeostasis via STAT5-Mediated Regulation of the Differentiation of BMSCs Into Adipocytes

    Researchers generated adipocyte-specific Stat5 conditional knockout mice to investigate the role of STAT5 in the adipogenesis of bone marrow mesenchymal stem cells (BMSCs).
    [Experimental & Molecular Medicine]

    Full Article

    Germinal GLT8D1, GATAD2A and SLC25A39 Mutations in a Patient with a Glomangiopericytal Tumor and Five Different Sarcomas over a 10-Year Period

    The authors reported the unique case of a 72-year-old patient who presented with glomangiopericytal tumor followed by six sarcomas of the extremities between 2007 and 2016.
    [Scientific Reports]

    Full Article

    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    REVIEWS

    The Effects of Locomotion on Bone Marrow Mesenchymal Stem Cell Fate: Insight Into Mechanical Regulation and Bone Formation

    Scientists summarize the regulatory effects of locomotion/mechanical loading on bone marrow MSC activities.
    [Cell and Bioscience]

    Full Article

    INDUSTRY AND POLICY NEWS

    Sandoz Canada Launches Its 6th Biosimilar with PrInclunox® and PrInclunox® HP

    Sandoz Canada, Inc. announced the launch of PrInclunox® and PrInclunox® HP. It is one of the first companies to make available a biosimilar version of enoxaparin sodium solution for injection, contributing to potentially help lower healthcare costs for Canadian hospitals and private and public payers.
    [Sandoz Canada, Inc.]

    Press Release

    Noxopharm’s Veyonda to Begin First-Line Sarcoma Treatment Testing

    Noxopharm Limited announced its CEP-2 study will begin shortly. CEP-2 is related to the Investigational New Drug approval of Veyonda® by the FDA based on evidence that Veyonda may increase generally poor response rates of sarcoma cancers to chemotherapy in combination with doxorubicin, for patients with soft tissue sarcomas.
    [Noxopharm Limited (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    Society for Developmental Biology 80th Annual Meeting

    July 12 – 16, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Associate – Primary Human Tumors

    Louisiana State University – New Orleans, Louisiana, United States

    Research Associate – Cell Therapy

    Astellas Pharma – Westborough, Massachusetts, United States

    Senior Scientific Editor – Cell Stem Cell

    Elsevier – Cambridge, Massachusetts, United States

    Postdoctoral Research Associate – Sarcoma

    Washington University in St. Louis – Saint Louis, Missouri, United States

    Postdoctoral Fellow – Cancer Immunology and Immunotherapy

    Columbia University Medical Center – New York City, New York, United States

    > See All Jobs

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