| Vol. 13.19 – 18 May, 2021 |
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| Biofunctional scaffolds were prepared by immobilizing mesenchymal stromal exosomes onto fibrous polyester materials and allowed cell-mediated delivery of membrane-bound vesicles. [Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established a paradigm shift in the understanding of the diverse and multifaceted roles of magnesium ion in bone healing. [Nature Communications] |
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| In genetic FGFR knockout models, culture, and xenograft synovial sarcoma models treated with the FGFR inhibitor BGJ398, scientists showed that FGFR1, FGFR2, and FGFR3 were crucial for tumor growth. [Journal of Clinical Investigation] |
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| The authors investigated whether luspatercept could modulate the functional properties of MSCs as key components of the bone marrow microenvironment. [Leukemia] |
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| Researchers found that bone marrow-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of pancreatic cancer cells, as well as tumor stemness. [Cancer Letters] |
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| Adropin in vitro reduced hydrogen peroxide-induced apoptosis in rat bone marrow MSCs and improved MSC survival with increased phosphorylation of Akt and extracellular regulated protein kinases. [Cell Death & Disease] |
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| Investigators showed that mesenchymal progenitors residing in skeletal muscle mediated the initial fibrotic response to bone injury and also participated in cartilage and bone formation. [Nature Communications] |
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| Scientists explored the protective effects and underlying mechanisms of kartogenin on articular cartilage degradation using mice with post-traumatic osteoarthritis. [Cell Death & Disease] |
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| Investigators carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS. [JCI Insight] |
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| Researchers generated adipocyte-specific Stat5 conditional knockout mice to investigate the role of STAT5 in the adipogenesis of bone marrow mesenchymal stem cells (BMSCs). [Experimental & Molecular Medicine] |
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| The authors reported the unique case of a 72-year-old patient who presented with glomangiopericytal tumor followed by six sarcomas of the extremities between 2007 and 2016. [Scientific Reports] |
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| Scientists summarize the regulatory effects of locomotion/mechanical loading on bone marrow MSC activities. [Cell and Bioscience] |
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| Sandoz Canada, Inc. announced the launch of PrInclunox® and PrInclunox® HP. It is one of the first companies to make available a biosimilar version of enoxaparin sodium solution for injection, contributing to potentially help lower healthcare costs for Canadian hospitals and private and public payers. [Sandoz Canada, Inc.] |
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| Noxopharm Limited announced its CEP-2 study will begin shortly. CEP-2 is related to the Investigational New Drug approval of Veyonda® by the FDA based on evidence that Veyonda may increase generally poor response rates of sarcoma cancers to chemotherapy in combination with doxorubicin, for patients with soft tissue sarcomas. [Noxopharm Limited (Business Wire, Inc.)] |
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| July 12 – 16, 2021 Virtual |
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| Louisiana State University – New Orleans, Louisiana, United States |
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| Astellas Pharma – Westborough, Massachusetts, United States |
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| Elsevier – Cambridge, Massachusetts, United States |
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| Washington University in St. Louis – Saint Louis, Missouri, United States |
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| Columbia University Medical Center – New York City, New York, United States |
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