Mesenchymal Cell News Volume 13.20 | May 25 2021

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    2021-05-25 | MESCN 13.20


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.20 – 25 May, 2021
    TOP STORY

    Comparative Evaluation of Isogenic Mesodermal and Ectomesodermal Chondrocytes from Human iPSCs for Cartilage Regeneration

    Investigators differentiated human induced pluripotent stem cells into the mesodermal and ectomesodermal lineages to prepare isogenic mesodermal cell-derived chondrocytes and neural crest cell-derived chondrocytes for comparative evaluation.
    [Science Advances]

    Full Article

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    SFRP2 Induces a Mesenchymal Subtype Transition by Suppression of SOX2 in Glioblastoma

    Scientists presented SFRP2 as a SOX2-antagonist with the capacity to induce a mesenchymal subtype transition in glioma cells located in vascular tumor areas, highlighting its role in glioblastoma tumor evolution and intratumoral heterogeneity.
    [Oncogene]

    Full Article

    Let-7f miRNA Regulates SDF-1α- and Hypoxia-Promoted Migration of Mesenchymal Stem Cells and Attenuates Mammary Tumor Growth upon Exosomal Release

    The authors examined intracellular levels of let-7f in 4T1 mammary carcinoma cells to test the hypothesis that let-7f released from human MSCs may be incorporated by tumor cells.
    [Cell Death & Disease]

    Full Article

    Bone Marrow Mesenchymal Stem Cells Promote Prostate Cancer Cell Stemness via Cell–Cell Contact to Activate the Jagged1/Notch1 Pathway

    Researchers investigated the effect of direct contact of prostate cancer (PCa) cells with MSCs on the stemness of PCa and its mechanisms.
    [Cell and Bioscience]

    Full Article

    DNA Methylation Changes during Long-Term In Vitro Cell Culture Are Caused by Epigenetic Drift

    Investigators identified CG dinucleotides that become continuously hyper- or hypomethylated during long-term culture of MSCs and other cell types.
    [Communications Biology]

    Full Article

    Mesenchymal Stromal Cell Mitochondrial Transfer to Human Induced T-Regulatory Cells Mediates FOXP3 Stability

    Scientists reported human inducible regulatory T cells (iTreg) co-cultured with bone marrow-derived MSCs during short-term ex vivo expansion enhanced the stability of iTreg FOXP3 expression and suppressive function in vitro and in vivo.
    [Scientific Reports]

    Full Article

    The KDM4B–CCAR1–MED1 Axis Is a Critical Regulator of Osteoclast Differentiation and Bone Homeostasis

    Researchers identified KDM4B as an epigenetic regulator of osteoclast differentiation. Knockdown of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated cells.
    [Bone Research]

    Full Article

    Single-Cell Characterization of Macrophages in Glioblastoma Reveals MARCO as a Mesenchymal Pro-Tumor Marker

    Scientists combined new and previously published single-cell RNA-seq data from 98,015 single cells from a total of 66 gliomas to profile 19,331 individual macrophages.
    [Genome Medicine]

    Full Article

    MFG-E8 Regulated by miR-99b-5p Protects against Osteoarthritis by Targeting Chondrocyte Senescence and Macrophage Reprogramming via the NF-κB Pathway

    The authors identified milk fat globule-epidermal growth factor 8 (MFG-E8) as a key factor mediating chondrocyte senescence and macrophage polarization and revealed its role in the pathology of osteoarthritis.
    [Cell Death & Disease]

    Full Article

    TP53 Mutations Increase Radioresistance in Rhabdomyosarcoma and Ewing Sarcoma

    Investigators determined the clinical phenotype of TP53 mutations and p53 pathway alterations in patients with rhabdomyosarcoma and Ewing sarcoma treated with radiation.
    [British Journal of Cancer]

    Abstract

    MiR-19b Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing through the WWP1/Smurf2-Mediated KLF5/β-Catenin Signaling Pathway

    Researchers modulated miR-19b expression via mimics/inhibitors in bone marrow MSCs and via agomirs in mice to explore the effects of these changes on osteogenic factors, bone cell mineralization, and the healing status of modeled fractures.
    [Experimental & Molecular Medicine]

    Full Article

    Human Placental Mesenchymal Stem Cells Ameliorate Liver Fibrosis in Mice by Upregulation of Caveolin1 in Hepatic Stellate Cells

    The authors established mouse models of CCl4-injured liver fibrosis (LF) and administered human placental MSCs (hPMSCs) at different stages of LF once a week for two weeks. The therapeutic effect of hPMSCs on LF was investigated, according to histopathological and blood biochemical analyses.
    [Stem Cell Research & Therapy]

    Full Article

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    REVIEWS

    Endocrine Role of Bone in the Regulation of Energy Metabolism

    Investigators summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.
    [Bone Research]

    Full Article

    INDUSTRY AND POLICY NEWS

    Stemedica Signs License Agreement with Pulthera, LLC for All Respiratory Indications Including Those Related to COVID-19

    Stemedica Cell Technologies, Inc. announced that it has signed a Licensing Agreement with Pulthera, LLC for the rights to use, distribute and sell its MSC technologies in the treatment of COVID-19 and additional pulmonary conditions.
    [Stemedica Cell Technologies, Inc.]

    Press Release

    Brazilian Health Regulatory Agency (ANVISA) Authorizes Sorrento Phase II Pivotal Clinical Trial of COVI-MSCâ„¢ in Hospitalized COVID-19 Patients with Acute Respiratory Distress Syndrome

    Sorrento Therapeutics, Inc. announced receipt of clearance from the ANVISA to proceed with a Phase II Pivotal clinical trial of COVI-MSCâ„¢, an injectable infusion of MSCs, for the treatment of hospitalized COVID-19 patients suffering from acute respiratory distress syndrome.
    [Sorrento Therapeutics, Inc.]

    Press Release

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    Hospital for Special Surgery – New York, New York, United States

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    Astellas Pharma – Westborough, Massachusetts, United States

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