 | | Vol. 13.21 – 1 June, 2021 |
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| Scientists engineered bi-specific Wnt mimetics that targeted Frizzled and low-density lipoprotein receptor-related proteins and evaluated their effects on bone accrual in murine models.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators presented evidence that during intramembranous bone formation osteoprogenitor cell proliferation was controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling.
[npj Regenerative Medicine] |
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| The authors focused on the emerging class of RNAs called long non-coding RNAs or lncRNAs and utilized an MSC-supported triple-negative breast cancer (TNBC) progression model to identify specific family members of functional relevance to TNBC pathogenesis.
[npj Breast Cancer] |
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| Researchers determined the roles of exosomes derived from adipose mesenchymal stem cells (ADSC-Exos) in wound skin tissue repair. Flow cytometry and electron microscopy were carried out to identify ADSCs and ADSC-Exos, respectively.
[Laboratory Investigation] |
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| Investigators studied whether and to what extent the conditionally immortalized cell line hFOB 1.19 could serve as a surrogate model for bone-marrow-derived MSCs.
[Scientific Reports] |
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| Using conditional lineage-tracing mice, scientists demonstrated that chondrocytes gave rise to a sizable fraction of mesenchymal progenitor cells, which served as progenitors of chondrocyte-derived osteoblasts.
[Cell Death & Disease] |
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| This prospective, single-arm, Phase II study evaluated the efficacy of the combination of pazopanib with topotecan in patients with metastatic or unresectable non-adipocytic soft-tissue sarcoma
[British Journal of Cancer] |
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| The safety and feasibility of using bone marrow-derived MSCs in combination with prodrug for the treatment of patients with primary and secondary glioblastoma multiform were assessed.
[Molecular Neurobiology] |
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| Researchers showed that CD13-deficient mice presented a low bone density phenotype with increased numbers of osteoclasts per bone surface, but displayed a normal distribution of osteoclast progenitor populations in the bone marrow and periphery.
[Scientific Reports] |
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| The authors review the evidence of autologous MSC therapy on pain, function and severity on imaging in knee osteoarthritis.
[British Journal of Sports Medicine] |
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| Investigators provide a detailed description of the functional properties of MSCs and extracellular vesicles and their potential clinical applications, with a special focus on pain treatment.
[British Journal of Pharmacology] |
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| Moleculin Biotech, Inc. announced it has received clearance to initiate its Phase Ib/II clinical trial evaluating Annamycin for the treatment of soft tissue sarcoma lung metastases.
[Moleculin Biotech, Inc.] |
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| July 12 – 15, 2021
Virtual |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | H. Lee Moffitt Cancer Center – Tampa, Florida, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Louisiana State University – New Orleans, Louisiana, United States |
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| | Broad Institute – Cambridge, Massachusetts, United States |
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