 | | Vol. 13.23 – 15 June, 2021 |
| |
|
|
| The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role is less clear. The authors demonstrated that cohesin complexes containing STAG2 occupied enhancer and polycomb repressive complex-marked regulatory regions.
[Cancer Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Investigators identified growth hormone receptor was mainly expressed in mesenchymal cells, and its expression was substantially decreased in idiopathic pulmonary fibrosis lungs.
[Science Advances] |
|
|
|
| Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard 2D cell culture dishes or encapsulated in other hydrogels.
[Biofabrication] |
|
|
|
| RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affected extracellular matrix genes, but not cytokine expression that was under the control of the NF-κB pathway.
[iScience] |
|
|
|
| To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, scientists analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.
[Scientific Reports] |
| |
|
|
| The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.
[Signal Transduction and Targeted Therapy] |
|
|
|
| Investigators showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.
[European Respiratory Journal] |
|
|
|
| By using a calvarial defect model, scientists showed that a senolytic cocktail improved the osteogenic capacity of aged bone marrow MSC both in vitro and in vivo.
[npj Regenerative Medicine] |
|
|
|
| Scientists analyzed tumor-infiltrating lymphocytes and immune checkpoint molecules in soft tissue sarcomas and assessed their prognostic impact regarding local recurrence, distant metastasis, and overall survival.
[British Journal of Cancer] |
|
|
|
| To evaluate the potential utility of including RNA-sequencing in the diagnostic process, investigators performed RNA-sequencing in 47 patients with suspected pediatric sarcomas.
[npj Genomic Medicine] |
|
|
|
| Researchers constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.
[Stem Cell Research & Therapy] |
|
|
|
|
| Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease] |
|
|
|
| Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports] |
|
|
|
|
| Calidi Biotherapeutics, Inc. announced its partnership with GenScript ProBio for assistance in the advertisement and distribution of Calidi’s proprietary technology platform: SuperNova-1 (SNV-1). The SNV-1 platform is composed of allogeneic, adipose-derived-MSC loaded with an oncolytic agent.
[Calidi Biotherapeutics, Inc. (Business Wire, Inc.)] |
|
|
|
| Essent Biologicsâ„¢ has announced the launch of its human MSCs for regenerative medicine, biopharmaceutical, and cell therapy research. Essent Biologics will provide highly-characterized, low-passaged human MSCs.
[Essent Biologics] |
|
|
|
|
| November 15 – 17, 2021
Ottawa, Ontario, Canada |
|
|
|
|
|
| | University of Southern California – Los Angeles, California, United States |
|
|
|
| | Bio-Techne – Minneapolis, Minnesota, United States |
|
|
|
| | Hannover Medical School – Hannover, Germany |
|
|
|
| | Sana Biotechnology – Multiple Locations, United States |
|
|
|
| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
