 | | Vol. 13.25 – 29 June, 2021 |
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| In mouse models of progressive osseous heteroplasia, a disease caused by null mutations in GNAS, researchers found that Gnas−/− mesenchymal cells secreted Sonic hedgehog (SHH), which induced osteoblast differentiation of the surrounding wild-type cells.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The use of a xenogeneic-free medium provided a suitable alternative for human bone marrow MSC expansion, due to the capability to maintain cell characteristic and potency.
[Scientific Reports] |
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| While the osteocytes are known as terminally differentiated cells derived from MSCs, the detailed mechanisms of osteocyte differentiation remain unclear. Scientists fabricated 3D self-organized spheroids using human MSCs.
[Scientific Reports] |
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| Investigators determined the growth factors content in conditioned medium of synovial membrane MSCs (SMMSCs-CM) as well as the chondrogenic and chondroprotective markers expression in osteoarthritis model after IGF1-induced and non-induced SMMSCs-CM treatments.
[Bioscience Reports] |
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| The authors investigated the differentiation capacity of human adult MSCs derived from adipose tissue into dopaminergic and neuron-like cells in the 3D culture plate.
[Neuroscience Letters] |
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| The authors revealed that the testis, like other organs, maintained multipotent mesenchymal progenitors that could be potentially leveraged in the development of future therapies for hypoandrogenism and/or infertility.
[Nature Communications] |
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| Researchers investigated the molecular mechanism whereby Stat3 regulated skeletal development and osteoblast differentiation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Dental pulp stem cells seeded in biodegradable scaffolds and transplanted into immunodeficient mice generated mature human blood vessels invested with smooth muscle actin-positive mural cells.
[Cell Death & Disease] |
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| Scientists revealed that (+)-ND could repress osteoclast synthesis, bone resorption function in vitro, and attenuated ovariectomy-triggered bone loss in vivo.
[Cell Death & Disease] |
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| Researchers provided evidence of the in vivo function of MMP-10 during endochondral ossification and defined the macrophages as the lead cell population in cartilage removal and vascular invasion.
[Journal of Bone and Mineral Research] |
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| Investigators discuss the potential of emerging microfluidic technologies providing new insights into the density, shape, and size of live cells, starting from heterogeneous or 3D cultured samples.
[Antibiotics] |
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| The authors summarize the current knowledge and explained the hypothetic theory of the mechanisms underlying orthodontic tooth movement through classifying the whole biomechanical events into four steps and introduced the developments of current study models and clinical applications.
[International Journal of Oral Science] |
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| TRACON Pharmaceuticals, Inc. announced that the FDA has granted Orphan Drug Designation to envafolimab for the treatment of patients with soft tissue sarcoma following submission of an amended application that included Phase I clinical trial data.
[TRACON Pharmaceuticals, Inc.] |
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| Trillium Therapeutics, Inc. announced that it has dosed the first patient with TTI-621, an investigational checkpoint inhibitor of the innate immune system, in combination with doxorubicin in a Phase Ib/II study in leiomyosarcoma.
[Trillium Therapeutics, Inc.] |
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| August 12 – 14, 2021
Busan, South Korea |
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| | University of Arkansas for Medical Sciences – Little Rock, Arkansas, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Hannover Medical School – Hannover, Germany |
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| | Sana Biotechnology – Multiple Locations, United States |
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