 | | Vol. 13.28 – 20 July, 2021 |
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| The authors revealed that dead MSCs alone in the therapeutic stem cell preparation or the apoptotic cells induced in vivo may exert the same immunomodulatory property as the “living MSCs preparation” through releasing phosphatidylserine.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators proposed an approach based on triboelectric stimulation to rejuvenate senescent bone marrow MSCs by fabricating a pulsed triboelectric nanogenerator that could produce stable pulsed current output unaffected by the triggered frequency.
[Advanced Science] |
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| Using a murine chronic myeloid leukemia (CML) model, scientists examined leukemia-induced alterations in mesenchymal cell populations and showed that 6C3+ stromal progenitors expanded in CML bone marrow and exhibited increased leukemia stem cells but reduced hematopoietic stem cell supportive capacity.
[Cell Reports] |
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| Researchers explored the connection between RAD52 motif-containing 1 (RDM1) and osteosarcoma (OS) progression, as well as the underlying mechanism. It was found that RDM1 was highly expressed in OS cells compared with human osteoblast cells.
[Journal of Cellular and Molecular Medicine] |
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| The authors set up a new natural scaffold deriving from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance and then subjected to in vitro recellularization with human bone marrow-derived MSCs.
[Scientific Reports] |
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| Investigators compared the therapeutic potential of a novel drug candidate, NTG-101 to MSCs, including rat cartilage-derived stem cells, bone marrow stem cells, and human umbilical cord-derived MSCs for the treatment of degenerative disc disease.
[Scientific Reports] |
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| The authors showed that refeeding after an overnight fast rapidly triggered proliferation and differentiation of oligodendrocyte progenitors, leading to the production of new oligodendrocytes in median eminence specifically.
[Cell Reports] |
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| Researchers investigated the efficacy comparison and interaction between fasting-mimicking diet and umbilical cord-derived-MSC infusion, aiming to establish effective type 2 diabetes therapies and explore its mechanism.
[Stem Cell Research & Therapy] |
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| Scientists assessed the safety and efficacy of injecting intravenous Wharton’s jelly-derived MSCs in patients with COVID-19 as a treatment. Five patients with severe COVID-19 were treated with Wharton’s jelly-derived MSCs.
[Stem Cell Research & Therapy] |
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| MSCs, a kind of multipotent stem cells with self-renewal ability and multi-differentiation ability, has become the “practical stem cells” for the treatment of diseases.
[Human Cell] |
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| Brooklyn ImmunoTherapeutics, Inc. announced that it had completed its acquisition of Novellus Therapeutics Limited. Novellus is developing next‑generation engineered MSC therapies using extensively patented mRNA-based cell reprogramming and gene editing technologies.
[Brooklyn ImmunoTherapeutics, Inc.] |
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| September 23 – 30, 2021
Virtual |
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| | The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Marion duPont Scott Equine Medical Center – Washington, DC, United States |
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| | Mercer University – Savannah, Georgia, United States |
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| | Florida State University – Tallahassee, Florida, United States |
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| | CellDrop Biosciences – Laramie, Wyoming, United States |
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