Mesenchymal Cell News Volume 13.30 | Aug 3 2021

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    2021-08-03 | MESCN 13.30


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.30 – 3 August, 2021
    TOP STORY

    FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

    Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that FLASH-PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard-PRT of the same dose.
    [Cancer Research]

    Abstract


    The StemSpanâ„¢ Leukemic Cell Culture Kit is optimized for in vitro culture and drug screening of human leukemic cells.
    PUBLICATIONSRanked by the impact factor of the journal

    PIK3R3, Part of the Regulatory Domain of PI3K, Is Upregulated in Sarcoma Stem-Like Cells and Promotes Invasion, Migration, and Chemotherapy Resistance

    To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
    [Cell Death & Disease]

    Full Article

    Mkx Mediates Tenogenic Differentiation but Incompletely Inhibits the Proliferation of Hypoxic MSCs

    A new strategy to modify MSCs to express specific chemokine receptors using mRNA engineering was developed to evaluate the homing ability of MSCs and their therapeutic effects for inflammatory bowel disease.
    [Stem Cell Research & Therapy]

    Full Article

    Human Adipose-Derived Mesenchymal Stromal Cells From Face and Abdomen Undergo Replicative Senescence and Loss of Genetic Integrity After Long-Term Culture

    The authors evaluated long-term culture of human facial adipose-derived MSCs (fASCs) and abdominal ASCs and showed that both met the criteria for MSC characterization but presented differences in their immunophenotypic profile, and differentiation and clonogenic potentials.
    [Experimental Cell Research]

    Abstract

    Host Defense against Klebsiella pneumoniae Pneumonia Is Augmented by Lung-Derived Mesenchymal Stem Cells

    Scientists determined the immunomodulatory, antibacterial, and therapeutic potential of purified murine stem cell Ag-1+ lung MSCs using in vitro cell culture and an in vivo mouse model of pneumonia caused by K. pneumoniae.
    [Journal of Immunology]

    Abstract

    Compromised Dental Cells Viability Following Teeth-Whitening Exposure

    The authors investigated the beneficial effects of exosomes derived from bone marrow MSCs on trabecular meshwork cells under oxidative stress and predicted candidate genes associated with this process.
    [Scientific Reports]

    Full Article

    Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells

    By engineering the t(11;22)(q24;q12) translocation together with a combination of STAG2, TP53, or CDKN2A mutations, researchers generated a wide collection of immortalized cells tolerating EWSR1-FLI1 expression from primary MSC derived from an Ewing sarcoma patient.
    [Cancer Research]

    Abstract

    The Use of Umbilical Cord-Derived Mesenchymal Stem Cells in Patients with Muscular Dystrophies: Results from Compassionate Use in Real-Life Settings

    The authors administered advanced therapy medicinal product containing umbilical cord-derived MSCs to 22 patients with muscular dystrophies.
    [Stem Cells Translational Medicine]

    Full Article

    MicroRNA-26a Shuttled by Extracellular Vesicles Secreted from Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Damage through KLF9-Mediated Regulation of TRAF2/KLF2 Axis

    Researchers investigated the role of miR-26a shuttled by extracellular vesicles derived from adipose-derived MSCs in neuronal damage.
    [Adipocyte]

    Full Article


    Image of man completing the on-demand CFU assay course on his laptop.
    REVIEWS

    Is There a Place for Mesenchymal Stromal Cell-Based Therapies in the Therapeutic Armamentarium against COVID-19?

    The authors present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic’s unmet medical needs.
    [Stem Cell Research & Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Gives Green Light for Multiple Sclerosis Stem Cell Trial

    Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived MSCs in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.
    [Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    New Horizons in Alzheimer’s Disease

    October 27 – 28, 2021
    Virtual & Leuven, Belgium

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Human Gastrointestinal Organoids

    Cincinnati Children’s Hospital – Cincinnati, Ohio, United States

    Postdoctoral Position – Mechanisms of Skeletal Development

    The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    Laboratory Specialist – Orthopedic Research

    Marion duPont Scott Equine Medical Center – Washington, DC, United States

    Research Assistant – Immunobiology of MSCs

    Mercer University – Savannah, Georgia, United States

    Postdoctoral Researchers – Drug Discovery and Enzymology

    Florida State University – Tallahassee, Florida, United States

    > See All Jobs

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