| Vol. 13.30 – 3 August, 2021 |
| |
|
|
| Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that FLASH-PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard-PRT of the same dose. [Cancer Research] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations. [Cell Death & Disease] |
|
|
|
| A new strategy to modify MSCs to express specific chemokine receptors using mRNA engineering was developed to evaluate the homing ability of MSCs and their therapeutic effects for inflammatory bowel disease. [Stem Cell Research & Therapy] |
|
|
|
| The authors evaluated long-term culture of human facial adipose-derived MSCs (fASCs) and abdominal ASCs and showed that both met the criteria for MSC characterization but presented differences in their immunophenotypic profile, and differentiation and clonogenic potentials. [Experimental Cell Research] |
|
|
|
| Scientists determined the immunomodulatory, antibacterial, and therapeutic potential of purified murine stem cell Ag-1+ lung MSCs using in vitro cell culture and an in vivo mouse model of pneumonia caused by K. pneumoniae. [Journal of Immunology] |
|
|
|
| The authors investigated the beneficial effects of exosomes derived from bone marrow MSCs on trabecular meshwork cells under oxidative stress and predicted candidate genes associated with this process. [Scientific Reports] |
|
|
|
|
| By engineering the t(11;22)(q24;q12) translocation together with a combination of STAG2, TP53, or CDKN2A mutations, researchers generated a wide collection of immortalized cells tolerating EWSR1-FLI1 expression from primary MSC derived from an Ewing sarcoma patient. [Cancer Research] |
|
|
|
| The authors administered advanced therapy medicinal product containing umbilical cord-derived MSCs to 22 patients with muscular dystrophies. [Stem Cells Translational Medicine] |
|
|
|
| Researchers investigated the role of miR-26a shuttled by extracellular vesicles derived from adipose-derived MSCs in neuronal damage. [Adipocyte] |
|
|
|
|
| The authors present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic’s unmet medical needs. [Stem Cell Research & Therapy] |
|
|
|
|
| Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived MSCs in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis. [Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)] |
|
| | | October 27 – 28, 2021 Virtual & Leuven, Belgium |
|
|
| | | | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
|
|
| | The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
|
|
| | Marion duPont Scott Equine Medical Center – Washington, DC, United States |
|
|
| | Mercer University – Savannah, Georgia, United States |
|
|
| | Florida State University – Tallahassee, Florida, United States |
|
|
| |
|