 | | Vol. 13.31 – 10 August, 2021 |
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| In the liver, ductal cells rarely proliferate during homeostasis but do so transiently after tissue injury. Using organoid co-cultures that recapitulated the ductal-to-mesenchymal cell architecture of the portal tract, researchers demonstrated that a subpopulation of mouse periportal mesenchymal cells exerted dual control on proliferation of the epithelium.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors analyzed hypoxia impact on human and pig bone marrow-derived MSCs and mouse myoblast proliferation, differentiation, and fusion.
[Stem Cell Research & Therapy] |
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| Researchers compared the biological and functional characteristics of naïve MLpvNG2 cells with identical bone marrow-derived MSCs using in vitro and in vivo procedures.
[Stem Cell Research] |
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| Scientists generated an induced pluripotent stem cells (iPSC) line from bone marrow-MSCs employing a non-integrating episomal vector. The generated iPSCs expressed pluripotency markers, showed a normal karyotype, and exhibited the potential for in vitro differentiation into three germ layers.
[Stem Cell Research] |
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| Investigators determined the ratio of patients whose synovial MSCs were transplanted clinically, to intensively investigate MSCs with trisomy 7 from a safety perspective, and to follow up the patients for five years after transplantation.
[Stem Cells Translational Medicine] |
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| To determine the function of umbilical cord blood (UCB)-MSCs, scientists examined and compared the therapeutic effects of UCB-MSCs and UCB-MSC-derived exosomes on skin healing in rats.
[Stem Cell Research & Therapy] |
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| Researchers evaluated intratracheal MSCs as an approach to treat an hyperoxia-induced bronchopulmonary dysplasia animal model and compared the therapeutic effects between amniotic fluid-, umbilical cord- and bone marrow-MSCs.
[Journal of Cellular and Molecular Medicine] |
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| A qPCR analytical method with matrix effect was developed to track the biodistribution of human mesenchymal stem cells in normal and Con A induced liver injury mice.
[Journal of Pharmacology and Experimental Therapeutics] |
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| Investigators developed a Phase IIb, multicentre, randomized, double-blind, placebo-controlled clinical trial protocol to evaluate the safety and efficacy of intravenous administration of allogeneic adipose tissue-derived MSCs in patients with acute ischaemic stroke, concurrently with conventional stroke treatment.
[Bmj Open] |
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| Scientists summarize findings to advocate the reactivation of tumor suppressors p53 and PTEN in glioblastoma treatment and use MSCs as a “Trojan horse” to carry oncolytic viral cargo to disseminated tumor beds.
[Stem Cell Reviews and Reports] |
| | The authors describe the basic characteristics and biological functions of menstrual blood-derived MSCs-derived small extracellular vesicles.
[Stem Cell Research & Therapy] |
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| Imugene Ltd and Celularity Inc. announced they have entered into a research collaboration in 2021. Imugene and Celularity will initially collaborate to develop the combination of Imugene’s CD19 oncolytic virus technology and Celularity’s CD19 targeting allogeneic chimeric antigen receptor (CAR) T cellular therapy, CYCART-19, for the treatment of solid tumors.
[Celularity Inc] |
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| The Office of Research recently awarded a total of $435,000 in three proof-of concept grant programs for faculty, while the Office of Public Scholarship and Engagement gave a total of $67,500 in seed and bridge grants to faculty for publicly engaged research projects.
[University of California, Davis] |
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| September 22 – 25, 2021
Virtual |
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| | The Geneva Foundation – Tacoma, Washington, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Mercer University – Savannah, Georgia, United States |
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