 | | Vol. 13.32 – 17 August, 2021 |
| |
|
|
| Investigators examined the antitumor effects of EWS/FLI1-rejuvenated CTLs against Ewing sarcoma. The altered amino acid sequence at the break/fusion point of EWS/FLI1, when presented as a neoantigen, evokes an immune response that targets EWS/FLI1+ sarcoma.
[Cancer Immunology Research] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Researchers compared the therapeutic potential of induced pluripotent stem cells differentiation into MSCs generated from urinary epithelial cells with the available umbilical cord MSCs.
[Journal of Cellular and Molecular Medicine] |
|
|
|
| Scientists explored the role of concentrated growth factor membranes in periodontal tissue regeneration mediated by human umbilical cord MSCs.
[Stem Cells International] |
|
|
|
| For translation of our findings, investigators combined in vitro cytochemical, molecular and pharmacologic assays on human cardiac MSCs, from myocardial biopsies of healthy controls and arrhythmogenic cardiomyopathy (AC) patients, with the use of existing drugs to interfere with the predicted AC mechanisms.
[International Journal of Cardiology] |
|
|
|
| The authors revealed that the nuclear factor erythroid 2–related factor 2 (NRF2)-conditioned medium protected the wharton’s jelly derived-MSCs against H2O2-induced toxicity in vitro.
[Journal of Tissue Viability] |
| |
|
|
| Coinjections of endothelial progenitor cells + MSCs significantly enhanced the survival rate of lipopolysaccharide-induced mice, decreased concentrations of pro-inflammatory cytokines, and increased the level of anti-inflammatory cytokine.
[Journal of Cellular Biochemistry] |
|
|
|
| Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.
[Cell Death Discovery] |
|
|
|
| A 3D in vitro compartmented cell culture system consisting of a neonatal dorsal root ganglion adjacent to a nerve graft was used to evaluate the regenerating neurites into the peripheral nerve scaffold.
[Biotechnology and Bioengineering] |
|
|
|
| After stimulation with Zeb2/Axin2-enriched bone marrow MSC (BMSC) exosomes, the spatial memory and nerve function of MCAO rats showed marked recovery. The number of neurons was increased in the subventricular zone, hippocampus, and cortex area, while the expression of nerve growth factors was upregulated.
[Journal of Molecular Neuroscience] |
|  |
|
|
|
| Most of the 416 published trials evaluated MSCs’ effectiveness in treating cardiovascular diseases, GvHD, and brain and neurological disorders, although some trials sought to treat immune system diseases and wounds and to restore tissue.
[Stem Cell Reviews and Reports] |
|
|
|
| Scientists summarize the effect and mechanism of long non-coding RNA H19 on osteogenic differentiation of various stem cells reported in the published literatures. The role and mechanism of H19, H19 expression changes, effect of H19 on cell proliferation in osteogenic differentiation were respectively reviewed.
[Molecular Medicine] |
|
|
|
|
| ERS Genomics Limited announced a non-exclusive license agreement granting CET access to ERS Genomics’ CRISPR/Cas9 patent portfolio.
[ERS Genomics Limited] |
|
|
|
| Epizyme, Inc. and HUTCHMED announced a collaboration to research, develop, manufacture and commercialize TAZVERIK® in Greater China, including mainland China, Hong Kong, Macau and Taiwan. TAZVERIK® is a methyltransferase inhibitor of EZH2 developed by Epizyme that is approved by the FDA for the treatment of certain patients with epithelioid sarcoma and certain patients with follicular lymphoma.
[Epizyme, Inc.] |
|
|
|
|
| November 22 – 23, 2021
Ghent, Belgium |
|
|
|
|
|
| | Danaher – Toronto, Ontario, Canada |
|
|
|
| | Michigan State University – East Lansing, Michigan, United States |
|
|
|
| | The Geneva Foundation – Tacoma, Washington, United States |
|
|
|
| | Dalhousie University – Halifax, Nova Scotia, Canada |
|
|
|
| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
