Mesenchymal Cell News Volume 13.34 | Aug 31 2021

    0
    21







    2021-08-31 | MESCN 13.34


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.34 – 31 August, 2021
    TOP STORY

    Spatiotemporal Extracellular Matrix Modelling (StEMM) for In Situ Cell Niche Studies

    Researchers developed an in situ representation of the cardiac extracellular matrix (ECM) that was useful for assessment of repopulation dynamics and to study the effect of local ECM composition on phenotype preservation of reseeded mesenchymal progenitor cells.
    [Stem Cells]

    Full Article
    Subscribe to the Stem Cell Podcast newsletter for a chance to win a bluetooth speaker.
    PUBLICATIONSRanked by the impact factor of the journal

    CD146 Controls the Quality of Clinical Grade Mesenchymal Stem Cells from Human Dental Pulp

    Scientists compared stem cell properties of dental pulp-derived human MSCs at passages 5, 10 and 20 under serum and serum-free culture conditions. Cell morphology, proliferation capacity, chromosomal stability, surface phenotypic profiles, differentiation and immunoregulation ability were evaluated.
    [Stem Cell Research & Therapy]

    Full Article

    Phagocytosis by Stroma Confounds Co-Culture Studies

    Investigators showed that mesenchymal stromal cells from selected donors and NKTert, a stromal cell line, which is commonly used for co-culture studies with primary leukemia cells, extensively phagocytosed apoptotic cells.
    [iScience]

    Full ArticleGraphical Abstract

    Mesenchymal Stem Cell-Derived Exosomes Block Malignant Behaviors of Hepatocellular Carcinoma Stem Cells through a lncRNA C5orf66-AS1/MicroRNA-127-3p/DUSP1/ERK Axis

    Exosomes from the procured human bone marrow-MSCs were extracted and identified. Cancer stem cells from hepatocellular carcinoma cell lines were collected.
    [Human Cell]

    Abstract

    Biofabrication of Allogenic Bone Grafts Using Cellularized Amniotic Scaffolds for Application in Efficient Bone Healing

    Using a gradient change of detergents and continuous agitation, scientists developed a unique technique to generate completely cell-free amnion and chorion scaffolds. The absence of cellular components and integrity of biological and mechanical cues within decellularized human amnion and chorion were evaluated and compared with fresh membranes.
    [Tissue and Cell]

    Abstract

    Exosomal Micro‐RNA‐96 Derived From Bone Marrow Mesenchymal Stem Cells Inhibits Doxorubicin‐Induced Myocardial Toxicity by Inhibiting the Rac1/Nuclear Factor‐κB Signaling Pathway

    The authors investigated the functional mechanism of exosomal microRNA‐96 derived from bone marrow MSCs in myocardial toxicity induced by doxorubicin.
    [Journal of the American Heart Association]

    Full Article

    Melatonin Restores Osteoporosis-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells and Alleviates Bone Loss through the HGF/PTEN/Wnt/β-Catenin Axis

    Real-time qualitative PCR and Western blot analysis were conducted to determine expression of HGF, PTEN, and osteoblast differentiation-related genes in ovariectomy-induced osteoporosis mice and the isolated bone marrow MSCs.
    [Therapeutic Advances in Chronic Disease]

    Full Article

    A Fructosylated Peptide Derived from a Collagen II T Cell Epitope for Long-Term Treatment of Arthritis (FIA-CIA) in Mice

    Researchers investigated arthritis development in male DBA/1 mice which were injected with bovine collagen II and human fibrinogen on days 0 and 21, leading to stable and reproducible disease induction in 100% of immunized mice.
    [Scientific Reports]

    Full Article

    Clinical Outcomes of Frozen Autograft Reconstruction for the Treatment of Primary Bone Sarcoma in Adolescents and Young Adults

    Scientists evaluated the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults that was 15 to 39 years of age.
    [Scientific Reports]

    Full Article

    Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury

    The authors successfully established laparoscopic liver ischemia-reperfusion with partial hepatectomy in miniature pigs and injected saline, DMEM, adipose-derived stem cell (ADSC)-secretome, and ADSCs directly into the liver parenchyma immediately afterwards.
    [Stem Cells International]

    Full Article
    Find the Right Antibodies for Your Stem Cell Research. Learn More
    REVIEWS

    Mesenchymal Stem Cells in SARS-CoV-2 Infection: A Hype or Hope

    One therapeutic approach showing a ray of hope to combat COVID-19 infection is MSC therapy. Mesenchymal cells have immunomodulatory, anti-inflammatory as well as regenerative properties and various preliminary studies have shown that MSCs can reverse the lung damage and overcome the cytokine storm incited by COVID-19 infection.
    [Life Sciences]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    BioRestorative Therapies Receives Patent in Japan Related to its Off-the-Shelf ThermoStem® Program

    BioRestorative Therapies, Inc. announced that the Japanese Patent Office has issued the company a patent related to its metabolic ThermoStem® Program. Claims granted under the new patent cover methodologies related to brown adipocytes from human brown adipose-derived stem cells.
    [BioRestorative Therapies, Inc. (GlobeNewswire, Inc.)]

    Press Release

    Orthofix Announces US Launch and First Patient Implants with New fiberFUSE Strip – An Advanced Fiber Bone-Graft Solution Containing Cancellous Bone

    Orthofix Medical, Inc. announced the launch and first patient implants with the fiberFUSE™ Strip, an advanced demineralized fiber bone-graft solution containing cancellous bone. The fiberFUSE Strip is formulated as a convenient preformed bone-graft strip to enable optimized application for posterior cervical, posterior lumbar and degenerative spinal procedures.
    [Orthofix Medical, Inc.]

    Press Release

    University of Miami Researchers Enter Phase III of Stem Cell Clinical Trial in Treating COVID-19 Acute Respiratory Distress Syndrome

    A University of Miami Miller School of Medicine research team has launched a Phase III multicenter clinical trial to evaluate the effectiveness of mesenchymal stem cells in treating COVID-19 patients with acute respiratory distress syndrome.
    [University of Miami]

    Press Release
    FEATURED EVENT

    Vitamin D Workshop

    October 13 – 14, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Advanced Practice Provider – Stem Cell Transplantation

    Banner MD Anderson Cancer Center – Gilbert, Arizona, United States

    Postdoctoral Associate – Tumor Microenvironment

    Duke University – Durham, North Carolina, United States

    Postdoctoral Associate – Stem/Progenitor Cells

    Baylor College of Medicine – Houston, Texas, United States

    Research Associate – Stem Cell Models

    Michigan State University – East Lansing, Michigan, United States

    Development Engineer – Cell Therapies and Regenerative Medicine

    Danaher – Toronto, Ontario, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mesenchymal Cell News Twitter