| Vol. 13.35 – 7 September, 2021 |
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| Investigators demonstrated that nasal chondrocyte–based tissue-engineered cartilage maintained cartilaginous properties when exposed in vitro to inflammatory stimuli found in osteoarthritic joints and favorably altered the inflammatory profile of cells from osteoarthritic joints. [Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that the incorporation of gelatin microparticles coloaded with transforming growth factor beta 3 and matrilin 3 promoted chondrogenic differentiation of adipose-derived MSC spheroids while preventing hypertrophy and terminal differentiation of cells. [NPJ Regenerative Medicine] |
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| A thermosensitive acellular extracellular matrix hydrogel coupled with adipose-derived MSC (ADSC) exosomes that inherited the superior properties of nucleus pulposus tissue and ADSCs was fabricated to ameliorate intervertebral disc degeneration. [Journal of Nanobiotechnology] |
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| Modified mixed leukocyte reaction was performed between feline adipose-derived MSCs and PBMCs. Changes of cell cycle stages, phenotype and cellular senescence were determined through flow cytometry and gene expression analysis. [Stem Cell Research & Therapy] |
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| Investigators demonstrated that nasal chondrocyte–based tissue-engineered cartilage maintained cartilaginous properties when exposed in vitro to inflammatory stimuli found in osteoarthritic joints and favorably altered the inflammatory profile of cells from osteoarthritic joints. [Science Translational Medicine] |
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| The authors used a complementary and quantitative engineering approach based on sequential synthetic bottom-up assembly of fully functional extracellular vesicles with precisely controlled lipid, protein, and RNA composition. [Science Advances] |
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| Researchers found that cerebrospinal fluid pulsation stress—cyclic pulsation stress—could promote the osteogenic and angiogenic abilities of rat MSCs, thereby promoting tissue-engineered laminae’s bone and blood vessel formation. [NPJ Regenerative Medicine] |
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| Investigators developed a method using canine osteosarcoma in mouse xenografts to distinguish tumor-derived from host-response exosomal messenger RNAs. [Laboratory Investigation] |
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| Researchers evaluated the migration and distribution of embryonic stem cell-derived MSCs in a model of chemotherapy-induced premature ovarian failure. [Biochemical and Biophysical Research Communications] |
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| The authors evaluated the feasibility, safety, and efficacy of cell therapy based on MSCs derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. [Trials] |
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| Investigators review the molecular mechanisms of exosomes and internal microRNAs derived from MSCs in cardiac ischemic injury repair. [Biomedicine & Pharmacotherapy] |
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| The authors provide an overview of recent scientific reports concerning novel strategies that promote MSC transplantation as an effective therapeutic approach, including physical approaches, chemical agents, traditional Chinese medicines and extracts, and genetic modification. [Stem Cells International] |
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| Sorrento Therapeutics, Inc. announced the start of enrollment in its Phase II efficacy study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome in Brazil. [Sorrento Therapeutics, Inc.] |
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| BioRestorative Therapies, Inc. announced that the Australian Patent Office has issued the company a patent related to its metabolic ThermoStem® Program. [BioRestorative Therapies, Inc. (GlobeNewswire, Inc.)] |
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| October 19, 2021 London, England, United Kingdom |
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| Lund University – Lund, Sweden |
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| Banner MD Anderson Cancer Center – Gilbert, Arizona, United States |
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| Duke University – Durham, North Carolina, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Michigan State University – East Lansing, Michigan, United States |
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