Mesenchymal Cell News Volume 13.35 | Sep 7 2021

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    2021-09-07 | MESCN 13.35


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.35 – 7 September, 2021
    TOP STORY

    Engineered Nasal Cartilage for the Repair of Osteoarthritic Knee Cartilage Defects

    Investigators demonstrated that nasal chondrocyte–based tissue-engineered cartilage maintained cartilaginous properties when exposed in vitro to inflammatory stimuli found in osteoarthritic joints and favorably altered the inflammatory profile of cells from osteoarthritic joints.
    [Science Translational Medicine]

    AbstractPress Release
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Matrilin3/TGFβ3 Gelatin Microparticles Promote Chondrogenesis, Prevent Hypertrophy, and Induce Paracrine Release in MSC Spheroid for Disc Regeneration

    Scientists reported that the incorporation of gelatin microparticles coloaded with transforming growth factor beta 3 and matrilin 3 promoted chondrogenic differentiation of adipose-derived MSC spheroids while preventing hypertrophy and terminal differentiation of cells.
    [NPJ Regenerative Medicine]

    Full Article

    Injectable Exosome-Functionalized Extracellular Matrix Hydrogel for Metabolism Balance and Pyroptosis Regulation in Intervertebral Disc Degeneration

    A thermosensitive acellular extracellular matrix hydrogel coupled with adipose-derived MSC (ADSC) exosomes that inherited the superior properties of nucleus pulposus tissue and ADSCs was fabricated to ameliorate intervertebral disc degeneration.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Feline Adipose-Derived Mesenchymal Stem Cells Induce Effector Phenotype and Enhance Cytolytic Function of CD8+ T Cells

    Modified mixed leukocyte reaction was performed between feline adipose-derived MSCs and PBMCs. Changes of cell cycle stages, phenotype and cellular senescence were determined through flow cytometry and gene expression analysis.
    [Stem Cell Research & Therapy]

    Full Article

    Engineered Nasal Cartilage for the Repair of Osteoarthritic Knee Cartilage Defects

    Investigators demonstrated that nasal chondrocyte–based tissue-engineered cartilage maintained cartilaginous properties when exposed in vitro to inflammatory stimuli found in osteoarthritic joints and favorably altered the inflammatory profile of cells from osteoarthritic joints.
    [Science Translational Medicine]

    AbstractPress Release

    Bottom-Up Assembly of Biomedical Relevant Fully Synthetic Extracellular Vesicles

    The authors used a complementary and quantitative engineering approach based on sequential synthetic bottom-up assembly of fully functional extracellular vesicles with precisely controlled lipid, protein, and RNA composition.
    [Science Advances]

    Full Article

    Cyclic Pulsation Stress Promotes Bone Formation of Tissue Engineered Laminae through the F-Actin/YAP-1/β-Catenin Signaling Axis

    Researchers found that cerebrospinal fluid pulsation stress—cyclic pulsation stress—could promote the osteogenic and angiogenic abilities of rat MSCs, thereby promoting tissue-engineered laminae’s bone and blood vessel formation.
    [NPJ Regenerative Medicine]

    Abstract

    Development of an Exosomal Gene Signature to Detect Residual Disease in Dogs with Osteosarcoma Using a Novel Xenograft Platform and Machine Learning

    Investigators developed a method using canine osteosarcoma in mouse xenografts to distinguish tumor-derived from host-response exosomal messenger RNAs.
    [Laboratory Investigation]

    Abstract

    Tracking of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Premature Ovarian Failure Model Mice

    Researchers evaluated the migration and distribution of embryonic stem cell-derived MSCs in a model of chemotherapy-induced premature ovarian failure.
    [Biochemical and Biophysical Research Communications]

    Abstract

    Efficacy and Safety of Intramuscular Administration of Allogeneic Adipose Tissue Derived and Expanded Mesenchymal Stromal Cells in Diabetic Patients with Critical Limb Ischemia with No Possibility of Revascularization: Study Protocol for a Randomized Controlled Double-Blind Phase II Clinical Trial (the NOMA Trial)

    The authors evaluated the feasibility, safety, and efficacy of cell therapy based on MSCs derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization.
    [Trials]

    Full Article
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Mesenchymal Stem Cell-Derived Exosome microRNA as Therapy for Cardiac Ischemic Injury

    Investigators review the molecular mechanisms of exosomes and internal microRNAs derived from MSCs in cardiac ischemic injury repair.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress

    The authors provide an overview of recent scientific reports concerning novel strategies that promote MSC transplantation as an effective therapeutic approach, including physical approaches, chemical agents, traditional Chinese medicines and extracts, and genetic modification.
    [Stem Cells International]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sorrento Announces Enrollment of First Subject in Brazil Phase II Study of COVI-MSC for Treatment of COVID-19 Associated Acute Respiratory Distress in ICU Patients

    Sorrento Therapeutics, Inc. announced the start of enrollment in its Phase II efficacy study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome in Brazil.
    [Sorrento Therapeutics, Inc.]

    Press Release

    BioRestorative Therapies Receives Patent in Australia Related to its Off-the-Shelf ThermoStem® Program

    BioRestorative Therapies, Inc. announced that the Australian Patent Office has issued the company a patent related to its metabolic ThermoStem® Program.
    [BioRestorative Therapies, Inc. (GlobeNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    Annual London Stem Cell Network Symposium

    October 19, 2021
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Hematopoietic and Mesenchymal Cells

    Lund University – Lund, Sweden

    Advanced Practice Provider – Stem Cell Transplantation

    Banner MD Anderson Cancer Center – Gilbert, Arizona, United States

    Postdoctoral Associate – Tumor Microenvironment

    Duke University – Durham, North Carolina, United States

    Postdoctoral Associate – Stem/Progenitor Cells

    Baylor College of Medicine – Houston, Texas, United States

    Research Associate – Stem Cell Models

    Michigan State University – East Lansing, Michigan, United States

    > See All Jobs

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