 | | Vol. 23.26 – 21 September, 2021 |
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| Scientists used 3D weaving, additive manufacturing, and autologous MSCs to create a tissue-engineered, bicomponent implant to restore hip function in a canine hip osteoarthritis model.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A cartilage regenerative system was developed based on a chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid containing synovial MSCs and recruiting tetrahedral framework nucleic acid injected into the articular cavity.
[Biomaterials] |
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| Evaluations of angiogenesis and osteogenesis were conducted via both in vitro cell culture using human bone marrow MSCs and in vivo implantation using a rat model of calvarial defect.
[Biomedical Materials] |
| | Researchers showed that aged MSCs exhibited reduced chromatin accessibility and lowered histone acetylation, particularly on promoters and enhancers of osteogenic genes.
[Nature Aging] |
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| Investigatorstested the efficacy of the MSC secretome in a physiologically relevant ex vivo equine skin biofilm explant model and explored the impact of the MSC secretome on the antimicrobial defense mechanisms of resident skin cells.
[Stem Cells Translational Medicine] |
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| Researchers investigated whether co-grafting of MSCs could improve the survival and reinnervation ability of dopaminergic precursors transplanted in animal models of Parkinson’s disease.
[Journal of Cellular and Molecular Medicine] |
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| Scientists developed a system in which cytokine may be administered intravenously without toxic side effects. MSCs were used as carriers of the IL-12.
[Scientific Reports] |
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| The authors examined the benefits of serum-free conditioned medium from stem cells derived from human exfoliated deciduous teeth on a murine non-alcoholic steatohepatitis (NASH) model induced by a combination of Western diet and repeated administration of low doses of carbon tetrachloride intraperitoneally, focusing on the gut-liver axis.
[Scientific Reports] |
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| Researchers investigated the efficacy of N-acetylcysteine and ascorbic-acid 2 phosphate oral supplementation as preventative measure against MSC impairment. Healthy wildtype control and obese diabetic mice received either placebo or antioxidant supplementation for a period of six weeks.
[Stem Cells and Development] |
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| Scientists investigated the therapeutic efficacy of intra-articular injection of bone marrow MSCs transfected with miR-29a-3p inhibitor in osteoarthritis.
[Tissue Engineering and Regenerative Medicine] |
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| Investigators provide an overview of humab bone-marrow-MSCs, the application of these cells to various neurological diseases, and improvements in their quality and freshness based on integrated omics after detachment from the culture dish for successful cell therapy.
[Stem Cell International] |
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| MSCs were isolated from first-trimester and term placentae. BM-MSCs were commercially obtained. Chondrogenesis was induced by micromass culture in commercial chondrogenic media for 7, 14, or 21 days.
[Cartilage] |
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| Celularity Inc. and Oncternal Therapeutics, Inc. announced they have entered into a research collaboration to evaluate placental derived-cellular therapies targeting receptor-tyrosine kinase-like Orphan Receptor 1.
[Celularity, Inc.] |
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| Frank Barry, Ph.D., has been selected as the new director of the C. Wayne McIlwraith Translational Medicine Institute at Colorado State University. Barry’s research and interests include stem cell biology and the development of cell-based repair strategies for osteoarthritis.
[Colorado State University] |
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| October 19, 2021
London, England, United Kingdom |
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| | NHS Blood and Transplant – Oxford, England, United Kingdom |
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| | King Abdullah University of Science and Technology – Thuwal, Saudi Arabia |
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| | Broad Institute – Cambridge, Massachusetts, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Lund University – Lund, Sweden |
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