 | | Vol. 23.39 – 5 October, 2021 |
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| Investigators found that following traumatic injury to ear pinnae, myofibroblasts appeared rapidly in both Acomys and mouse yet persisted only in mouse.
[Developmental Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The impact of 3D co-culture of human fetal pancreatic-derived mesenchymal cells with human embryonic stem cell-derived pancreatic progenitors development towards endocrine and beta cells was assessed.
[Stem Cell Reviews and Reports] |
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| Researchers developed a T cell receptor-like antibody that binds Synovial Sarcoma X breakpoint 2 (SSX2) peptide 41-49 in the context of HLA-A*-0201.
[Molecular Therapy-Methods & Clinical Development] |
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| The authors showed that F127 hydrogel containing FMZC is a suitable and nontoxic construct for encapsulation of MSCs in the presence of lysozyme and UVA irradiation, bearing high stem cell viability and proliferation.
[European Journal of Pharmaceutical Sciences] |
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| Investigators found that tumor necrosis factor-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.
[Stem Cells and Development] |
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| MSCs were characterized by flow cytometry with more than 90% CD44 and 75% Sca-1 labeling. Mineralization was validated with paracellular alkaline phosphatase activity, collagen birefringence, and mineral deposition confirming MSCs identity.
[Biochemical and Biophysical Research Communications] |
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| Genetic variant was identified with exome sequencing. The human dental pulp cells isolated from a patient with Cowden syndrome were investigated for their proliferation, osteogenesis, adipogenesis, and gene expression compared with controls.
[Oral Diseases] |
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| Scientists determined whether serelaxin (RLX) could enhance the therapeutic efficacy of bone-marrow-derived- mesecnymal stem cell-exosomes (BM-MSC-EXO), and compared the renoprotective effects of RLX and BM-MSC-EXO versus RLX and BM-MSCs in mice with hypertensive chronic kidney disease.
[Biomedicine & Pharmacotherapy] |
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| These in vitro data suggest that Hop2 inhibited adipogenesis by suppressing CEBP-mediated transactivation. Consistent with a negative role for Hop2 in adipogenesis, ablation of Hop2 in mice led to increased body weight, adipose volume, adipocyte size, and adipogenic marker gene expression.
[Journal of Biological Chemistry] |
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| The authors evaluated enhanced therapeutic effects of tonsil-derived mesenchymal stem cells on a murine colitis model using 3D culture method.
[Scientific Reports] |
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| Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.
[Pharmacology & Therapeutics] |
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| Following a review of over 4,000 adult patients with limb sarcoma from our specialist soft-tissue tumor database, scientists summarize the literature and their imaging findings, with emphasis on radiological hallmarks that can aid in diagnosis and management.
[Clinical Radiology] |
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| The University of California, Riverside, has received a grant of $5 million from the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians in stem cell research.
[University of California, Riverside] |
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| November 8 – 16, 2021
Chicago, Ilinois, United States & Online |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | NHS Blood and Transplant – Oxford, England, United Kingdom |
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| | King Abdullah University of Science and Technology – Thuwal, Saudi Arabia |
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| | Broad Institute – Cambridge, Massachusetts, United States |
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