Mesenchymal Cell News Volume 13.41 | Oct 19 2021

May 12, 2022

2021-10-19 | MESCN 13.41

Mesenchymal Cell News by STEMCELL Technologies

Vol. 13.41 – 19 October, 2021

TOP STORY

Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis

DNA supramolecular hydrogel was applied as delivering material for MSCs to treat a severe osteoarthritis model, which performed extraordinary protection in MSCs against shear force both in vitro and in vivo.
[Advanced Materials]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

IN VITRO

Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly(D,L-lactide) Composite Inducing Formation of Anisotropic Collagen Matrix

Inspired by the composition and microstructure of natural bone, researchers developed a biphasic composite consisting of highly aligned strontium/copper-doped one-dimensional hydroxyapatite and poly(D,L-lactide).
[ACS Nano]

Full Article Graphical Abstract

Healthy versus Inflamed Lung Environments Differentially Affect Mesenchymal Stromal Cells

Scientists comparatively assessed how the inflammatory environment present in acute respiratory distress syndrome lungs versus the lung environment present in healthy volunteers altered MSC behavior.
[European Respiratory Journal]

Abstract

Safety and Efficacy of Human Juvenile Chondrocyte-Derived Cell Sheets for Osteochondral Defect Treatment

Investigators demonstrated preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte sheets produced from routine surgical discards using thermo-responsive cultureware.
[NPJ Regenerative Medicine]

Full Article

Development of Injectable Graphene Oxide/Laponite/Gelatin Hydrogel Containing Wharton’s Jelly Mesenchymal Stem Cells for Treatment of Oxidative Stress-Damaged Cardiomyocytes

Injectable graphene oxide (GO)/laponite/gelatin hydrogel was developed and characterized. The results of cell viability showed that the optimal concentration of GO flasks to treat cells was 100 μg/ml.
[Colloids and Surfaces B-Biointerfaces]

Abstract Graphical Abstract

Smoc1 and Smoc2 Regulate Bone Formation as Downstream Molecules of Runx2

To address the roles played by Runx2-regulated genes in bone formation, the authors identified Runx2 targets by performing RNA-sequencing and found Smoc1 and Smoc2 upregulation by Runx2.
[Communications Biology]

Full Article

IN VIVO

Autophagy in Mesenchymal Progenitors Protects Mice against Bone Marrow Failure after Severe Intermittent Stress

Researchers identified Wnt5a in Osterix⁺ mesenchymal progenitor and stem cells as a critical factor for niche-dependent hematopoiesis.
[Blood]

Abstract

PARK7 Promotes Repair in Early Steroid-Induced Osteonecrosis of the Femoral Head by Enhancing Resistance to Stress-Induced Apoptosis in Bone Marrow Mesenchymal Stem Cells via Regulation of the Nrf2 Signaling Pathway

Scientists investigated the mechanism driving a PARK7-mediated resistance to apoptosis in bone marrow MSCs and indicated that PARK7 promoted the disintegration of nuclear factor–like 2 (Nrf2)/Kelch-like echinacoside–associated protein 1 complex.
[Cell Death & Disease]

Full Article

Angiogenic Effects of Cell Therapy within a Biomaterial Scaffold in a Rat Hind Limb Ischemia Model

Investigators evaluated the ability of mast cells and MSCs to induce angiogenesis in a rat model of ischemic hind limb injury on a background of a tissue engineered hydrogel scaffold.
[Scientific Reports]

Full Article

Extracellular Vesicles Secreted from Mesenchymal Stem Cells Exert Anti-Apoptotic and Anti-Inflammatory Effects via Transmitting microRNA-18b in Rats with Diabetic Retinopathy

Researchers investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.
[International Immunopharmacology]

Abstract

Genetic Deletion of the Cannabinoid Receptors CB1 and CB2 Enhances Inflammation with Diverging Effects on Skin Wound Healing in Mice

In order to clarify the role of endocannabinoid system receptors in wound healing, excisional wounds were created on wildtype and CB1 and CB2 knockout mice.
[Life Sciences]

Abstract

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REVIEWS

Dissecting the Relationship between Antimicrobial Peptides and Mesenchymal Stem Cells

The authors discuss the production of antimicrobial peptides by MSCs, revise the multiple functions of these peptides, including their influence over MSCs, and present an overview of clinical situations in which the antimicrobial properties of MSCs may be explored for therapy.
[Pharmacology & Therapeutics]

Abstract

Combining Systemic and Locally Applied Cellular Therapies for the Treatment of Systemic Sclerosis

Investigators provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.
[Bone Marrow Transplantation]

Abstract

INDUSTRY AND POLICY NEWS

RedDress Earns a Strategic Partnership with MediGroup

RedDress announced that it has entered into a partnership with MediGroup to deliver its innovative wound care solution, ActiGraft^® system to MediGroup’s members.
[RedDress (GlobeNewsWire, Inc.)]

Press Release

Ambulero’s Gene Therapy Candidate AMB-301 Granted US Orphan Drug Designation for Treatment of Severe Vascular Disease

Ambulero, Inc. announced that the US FDA’s Office For Orphan Products Development granted the company’s request for orphan drug status for its gene therapy candidate, AMB-301, to treat Buerger’s Disease, also known as Thromboangiitis Obliterans.
[Ambulero, Inc.]

Press Release

FEATURED EVENT

Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis

Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly(D,L-lactide) Composite Inducing Formation of Anisotropic Collagen Matrix

Healthy versus Inflamed Lung Environments Differentially Affect Mesenchymal Stromal Cells

Safety and Efficacy of Human Juvenile Chondrocyte-Derived Cell Sheets for Osteochondral Defect Treatment

Development of Injectable Graphene Oxide/Laponite/Gelatin Hydrogel Containing Wharton’s Jelly Mesenchymal Stem Cells for Treatment of Oxidative Stress-Damaged Cardiomyocytes

Smoc1 and Smoc2 Regulate Bone Formation as Downstream Molecules of Runx2

Autophagy in Mesenchymal Progenitors Protects Mice against Bone Marrow Failure after Severe Intermittent Stress

PARK7 Promotes Repair in Early Steroid-Induced Osteonecrosis of the Femoral Head by Enhancing Resistance to Stress-Induced Apoptosis in Bone Marrow Mesenchymal Stem Cells via Regulation of the Nrf2 Signaling Pathway

Angiogenic Effects of Cell Therapy within a Biomaterial Scaffold in a Rat Hind Limb Ischemia Model

Extracellular Vesicles Secreted from Mesenchymal Stem Cells Exert Anti-Apoptotic and Anti-Inflammatory Effects via Transmitting microRNA-18b in Rats with Diabetic Retinopathy

Genetic Deletion of the Cannabinoid Receptors CB1 and CB2 Enhances Inflammation with Diverging Effects on Skin Wound Healing in Mice

Dissecting the Relationship between Antimicrobial Peptides and Mesenchymal Stem Cells

Combining Systemic and Locally Applied Cellular Therapies for the Treatment of Systemic Sclerosis

RedDress Earns a Strategic Partnership with MediGroup

Ambulero’s Gene Therapy Candidate AMB-301 Granted US Orphan Drug Designation for Treatment of Severe Vascular Disease

The NYSCF Conference – New York Stem Cell Foundation

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Postdoctoral Fellow – Cancer Immunology & Stem Cell Engineering

Postdoctoral Research Fellow – Bone Repair

Postdoctoral Researcher – Stem Cells and Epithelia Mechanobiology

Postdoctoral Position – Stem Cells and Disease Modeling

Scientist – Mesenchymal Stem Cell Lineages

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